Contemporary Management of Polycystic Ovarian Syndrome
Abstract
PCOS remains one of the most intriguing endocrine disorders that physicians encounter even though it was first described over 80 years ago. Although the diagnostic criteria, nomenclature, and ideal therapeutic strategies are areas of active and ongoing debate, there is no doubt that we have made tremendous progress in improving the quality of life and reproductive outcomes of women who suffer from this wide-ranging disorder.
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Metformin is prescribed to target insulin resistance and pre-diabetes risk, androgen production, cardiometabolic risk factors and reproductive concerns.
“Metformin was prescribed in 8% and 44% of respondents at diagnosis and at follow-up clinic visits, respectively, to target insulin resistance and pre-diabetes risk, androgen production, cardiometabolic risk factors and reproductive concerns [67–70].”
From Challenges in diagnosis and health care in polycystic ovary syndrome in Canada: a patient view to improve health care (2023) · cites this paper as [70]
Cites
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
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Androgen Excess in Women: Experience with Over 1000 Consecutive Patients
Azziz, R., Sanchez, L. A., Knochenhauer, E. S., Moran, C., Lazenby, J., Stephens, K. C., Taylor, K., & Boots, L. R. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031122 · Cited by 1,132 · see citing works
Balen, A. H., Morley, L. C., Misso, M., Franks, S., Legro, R. S., Wijeyaratne, C. N., Stener-Victorin, E., Fauser, B. C. J. M., Norman, R. J., & Teede, H. (2016) · Human Reproduction Update · doi:10.1093/humupd/dmw025 · Cited by 705 · see citing works
Cassar, S., Misso, M. L., Hopkins, W. G., Shaw, C. S., Teede, H. J., & Stepto, N. K. (2016) · Human Reproduction · doi:10.1093/humrep/dew243 · Cited by 415 · see citing works
Polycystic ovarian syndrome treated by ovarian electrocautery through the laparoscope
Gjönnaess, H. (1984) · Fertility and Sterility · doi:10.1016/s0015-0282(16)47534-5 · Cited by 381 · see citing works
Endocrine consequences of weight loss in obese, hyperandrogenic, anovulatory women
Guzick, D. S., Wing, R., Smith, D., Berga, S. L., & Winters, S. J. (1994) · Fertility and Sterility · doi:10.1016/s0015-0282(16)56632-1 · Cited by 246 · see citing works
Legro, R. S., Dodson, W. C., Kris-Etherton, P. M., Kunselman, A. R., Stetter, C. M., Williams, N. I., Gnatuk, C. L., Estes, S. J., Fleming, J., Allison, K. C., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-2778 · Cited by 242 · see citing works
Polycystic Ovarian Syndrome: Long-Term Health Consequences
Zore, T., Joshi, N., Lizneva, D., & Azziz, R. (2017) · Seminars in Reproductive Medicine · doi:10.1055/s-0037-1603096 · Cited by 72 · see citing works
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Sydora, B. C., Wilke, M. S., McPherson, M., Chambers, S., Ghosh, M., & Vine, D. F. (2023) · BMC Women's Health · doi:10.1186/s12905-023-02732-2 · Cited by 60 · see citing works
“Metformin was prescribed in 8% and 44% of respondents at diagnosis and at follow-up clinic visits, respectively, to target insulin resistance and pre-diabetes risk, androgen production, cardiometabolic risk factors and reproductive concerns [67–70].”
Background
- Authors
- ZIMMERMAN, L. D., SETTON, R., PEREIRA, N., & ROSENWAKS, Z.
- Affiliations
- Weill Cornell Medicine (US)
- Venue
- Clinical Obstetrics & Gynecology
- Published
- 2019-06
- Volume
- 62
- Issue
- 2
- Pages
- 271-281
- ISSN
- 0009-9201 (ISSN-L)
- OpenAlex
- W2938796162
- Cited by
- 8
- References
- 8
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 2 · 2021: 1
- FWCI
- 0.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Obstetrics & Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- polycystic ovary syndrome, PCOS management, diagnostic criteria, nomenclature, treatment options, reproductive outcomes, quality of life
- MeSH terms
- Letrozole, Androgen Antagonists, Clomiphene, Contraceptives, Oral, Combined, Estrogen Antagonists, Female, Follicle Stimulating Hormone, Gonadotropins, Humans, Hypoglycemic Agents, Luteinizing Hormone, Metformin, Polycystic Ovary Syndrome, Progestins, Sex Hormone-Binding Globulin, Testosterone, Biomarkers, Aromatase Inhibitors
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