The DOI matches its Crossref record; 289 of the 289 references it cites were found in a registry or an index.
Gut-liver axis: Recent concepts in pathophysiology in alcohol-associated liver disease
Open accessAbstract
The growing recognition of the role of the gut microbiome’s impact on alcohol-associated diseases, especially in alcohol-associated liver disease, emphasizes the need to understand molecular mechanisms involved in governing organ-organ communication to identify novel avenues to combat alcohol-associated diseases. The gut-liver axis refers to the bidirectional communication and interaction between the gut and the liver. Intestinal microbiota plays a pivotal role in maintaining homeostasis within the gut-liver axis, and this axis plays a significant role in alcohol-associated liver disease. The intricate communication between intestine and liver involves communication between multiple cellular components in each organ that enable them to carry out their physiological functions. In this review, we focus on novel approaches to understanding how chronic alcohol exposure impacts the microbiome and individual cells within the liver and intestine, as well as the impact of ethanol on the molecular machinery required for intraorgan and interorgan communication.
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“the gut-liver axis has been shown to play an important role in the development of ALD.5,6”
From Opposite regulation of intestinal and intrahepatic CD8 + T cells controls alcohol-associated liver disease progression (2025) · cites this paper as [5]
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Maccioni, L., Guan, Y., Kim, M., Parra, M. A., Peiffer, B., Fu, Y., Wang, Y., Lin, Y.-H., Mackowiak, B., Feng, D., et al. (2025) · Gut · doi:10.1136/gutjnl-2024-334412 · Cited by 21
Metadata
- Authors
- Raya Tonetti, F., Eguileor, A., Mrdjen, M., Pathak, V., Travers, J., Nagy, L. E., & Llorente, C.
- Affiliations
- Department of Medicine, University of California San Diego, La Jolla, California, USA
- Cleveland Clinic (US)
- University of California San Diego (US)
- Corresponding author
- Llorente, Cristina
- ORCID
- Venue
- Hepatology
- Published
- 2024-05-01
- Volume
- 80
- Issue
- 6
- Pages
- 1342-1371
- ISSN
- 0270-9139 (ISSN-L)
- 1527-3350
- PMC
- PMC11801230
- OpenAlex
- W4396562198
- Cited by
- 78
- References
- 289
- Citations by year
- 2026: 42 · 2025: 31 · 2024: 5
- FWCI
- 5.82
- Type
- journal article
- Language
- en
- Open access
- green
- pmc.ncbi.nlm.nih.gov
- Licence
- other-oa
- Locations
- Hepatology (publishedVersion)
- PubMed Central (publishedVersion, other-oa)
- PubMed (publishedVersion)
- Funders
- American Association for the Study of Liver Diseases (8998GA)
- Hellman Family Foundation
- Eusko Jaurlaritza (POS_2023_2_0015)
- National Institutes of Health (AA011999, DK120515)
- University of California, San Diego
- National Institute on Alcohol Abuse and Alcoholism (U01AA021890, R21AA030654, R01 AA021890, R21AA026398, R01AA016399, P50AA024333, P50AA011999, R01AA029106)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK048522, P30DK097948, P30DK120515)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (P30AR073761)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Keywords
- gut-liver axis, alcoholic liver disease, gut microbiota, chronic ethanol exposure, ethanol, inter-organ communication, liver pathophysiology, intestinal cells, hepatocytes
- MeSH terms
- Gastrointestinal Microbiome, Ethanol, Animals, Humans, Liver, Liver Diseases, Alcoholic
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