Gut-liver axis: Recent concepts in pathophysiology in alcohol-associated liver disease

TRPV6 Channel Mediates Alcohol-Induced Gut Barrier Dysfunction and Systemic Response

Meena, A. S., Shukla, P. K., Bell, B., Giorgianni, F., Caires, R., Fernández‐Peña, C., Beranová-Giorgianni, Š., Aihara, E., Montrose, M. H., Chaib, M., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2022.110937 · Cited by 47

Alcohol-Related Liver Disease: An Overview on Pathophysiology, Diagnosis and Therapeutic Perspectives

Ha, Y., Jeong, I., & Kim, T. H. (2022) · Biomedicines · doi:10.3390/biomedicines10102530 · Cited by 47

Alcohol metabolism in alcohol use disorder: a potential therapeutic target

Lehner, T., Gao, B., & Mackowiak, B. (2023) · Alcohol and Alcoholism · doi:10.1093/alcalc/agad077 · Cited by 46

Gut dysbiosis and serotonin: intestinal 5-HT as a ubiquitous membrane permeability regulator in host tissues, organs, and the brain

Szőke, H., Kovács, Z., Bókkon, I., Vagedes, J., Erdöfi-Szabó, A., Hegyi, G., Sterner, M.-G., Kiss, Á., & Kapócs, G. (2020) · Reviews in the Neurosciences · doi:10.1515/revneuro-2019-0095 · Cited by 44

Functionally Diverse Inflammatory Responses in Peripheral and Liver Monocytes in Alcohol‐Associated Hepatitis

Kim, A., Bellar, A., McMullen, M. R., Li, X., & Nagy, L. E. (2020) · Hepatology Communications · doi:10.1002/hep4.1563 · Cited by 44

Epigenetics of alcohol-related liver diseases

Habash, N. W., Sehrawat, T. S., Shah, V. H., & Cao, S. (2022) · JHEP Reports · doi:10.1016/j.jhepr.2022.100466 · Cited by 44

Galectin-3 Concentration in Liver Diseases.

Gudowska-Sawczuk, M., Gruszewska, E., Cylwik, B., et al. (2015) · PubMed · Cited by 43

Ethanol‐Induced Mast Cell‐Mediated Inflammation Leads to Increased Susceptibility of Intestinal Tumorigenesis in the APCΔ468 Min Mouse Model of Colon Cancer

Wimberly, A. L., Forsyth, C. B., Khan, M. W., Pemberton, A. D., Khazaie, K., & Keshavarzian, A. (2013) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2012.01894.x · Cited by 43

Antimicrobial proteins: intestinal guards to protect against liver disease

Hendrikx, T., & Schnabl, B. (2018) · Journal of Gastroenterology · doi:10.1007/s00535-018-1521-8 · Cited by 42

Hepatic phospholipids in alcoholic liver disease assessed by proton-decoupled 31P magnetic resonance spectroscopy

Schlemmer, H.-P., Sawatzki, T., Sammet, S., Dornacher, I., Bachert, P., KAICK, G. V., Waldherr, R., & Seitz, H. K. (2005) · Journal of Hepatology · doi:10.1016/j.jhep.2004.12.032 · Cited by 41

Kaempferol ameliorated alcoholic liver disease through inhibiting hepatic bile acid synthesis by targeting intestinal FXR-FGF15 signaling

Xiao, L., Xu, G., Chen, S., He, Y., Peng, F., & Yuan, C. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.155055 · Cited by 41

Pathogenesis of Alcoholic Fatty Liver a Narrative Review

Seitz, H. K., Moreira, B., & Neuman, M. G. (2023) · Life · doi:10.3390/life13081662 · Cited by 41

Functional and morphological alterations in small intestine mucosa of chronic alcoholics

Bhonchal, S., Nain, C. K., Prasad, K. K., Nada, R., Sharma, A. K., Sinha, S. K., & Singh, K. (2007) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2007.05080.x · Cited by 40

Cross talk between Paneth and tuft cells drives dysbiosis and inflammation in the gut mucosa

Coutry, N., Nguyen, J., Soualhi, S., Gerbe, F., Meslier, V., Dardalhon, V., Almeida, M., Quinquis, B., Thirion, F., Herbert, F., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2219431120 · Cited by 39

Galectin-3: therapeutic targeting in liver disease

MacKinnon, A. C., Tonev, D., Jacoby, B., Pinzani, M., & Slack, R. J. (2023) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2023.2258280 · Cited by 39

Microbiome Alterations in Alcohol Use Disorder and Alcoholic Liver Disease

Litwinowicz, K., & Gamian, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032461 · Cited by 38

Lactobacillus plantarum-Derived Postbiotics Ameliorate Acute Alcohol-Induced Liver Injury by Protecting Cells from Oxidative Damage, Improving Lipid Metabolism, and Regulating Intestinal Microbiota

Ye, W., Chen, Z., He, Z., Gong, H., Zhang, J., Sun, J., Yuan, S., Deng, J., Liu, Y., & Zeng, A. (2023) · Nutrients · doi:10.3390/nu15040845 · Cited by 37

Hepatic pIgR-mediated secretion of IgA limits bacterial translocation and prevents ethanol-induced liver disease in mice

Hendrikx, T., Lang, S., Rajcic, D., Wang, Y., McArdle, S., Kim, K., Mikulski, Z., & Schnabl, B. (2023) · Gut · doi:10.1136/gutjnl-2022-328265 · Cited by 37

Diagnostic and Prognostic Significance of Complement in Patients With Alcohol‐Associated Hepatitis

Fan, X., McCullough, R. L., Huang, E., Bellar, A., Kim, A., Poulsen, K. L., McClain, C. J., Mitchell, M. C., McCullough, A. J., Radaeva, S., et al. (2020) · Hepatology · doi:10.1002/hep.31419 · Cited by 36

TH17 cells promote CNS inflammation by sensing danger signals via Mincle

Zhang, Q., Liu, W., Wang, H., Zhou, H., Bulek, K., Chen, X., Zhang, C., Zhao, J., Zhang, R., Liu, C., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30174-1 · Cited by 36

Interleukin-22 in alcoholic hepatitis and beyond

Xiang, X., Hwang, S., Feng, D., Shah, V. H., & Gao, B. (2020) · Hepatology International · doi:10.1007/s12072-020-10082-6 · Cited by 36

Development of Alcohol‐Associated Hepatitis Is Associated With Specific Changes in Gut‐Modified Bile Acids

Muthiah, M. D., Smirnova, E., Puri, P., et al. (2022) · Hepatology Communications · doi:10.1002/hep4.1885 · Cited by 36

Modulation of the Bile Acid Enterohepatic Cycle by Intestinal Microbiota Alleviates Alcohol Liver Disease

Ciocan, D. M., Spatz, M., Trainel, N., Hardonnière, K., Domenichini, S., Mercier‐Nomé, F., Desmons, A., Humbert, L., Durand, S., Kroemer, G., et al. (2022) · Cells · doi:10.3390/cells11060968 · Cited by 36

Key Signaling in Alcohol-Associated Liver Disease: The Role of Bile Acids

Way, G. W., Jackson, K. G., Muscu, S., & Zhou, H. (2022) · Cells · doi:10.3390/cells11081374 · Cited by 36

A perspective of intestinal immune-microbiome interactions in alcohol-associated Liver Disease

Bruellman, R. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.53589 · Cited by 35

Alcohol Impairs Immunometabolism and Promotes Naïve T Cell Differentiation to Pro-Inflammatory Th1 CD4+ T Cells

McTernan, P. M., Levitt, D. E., Welsh, D. A., Simon, L., Siggins, R. W., & Molina, P. E. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.839390 · Cited by 35

Highest Frequencies of Interleukin-22-Producing T Helper Cells in Alcoholic Hepatitis Patients with a Favourable Short-Term Course

Støy, S. H., Sandahl, T. D., Dige, A. K., Agnholt, J. S., Rasmussen, T. K., Grønbæk, H., Deleuran, B. W., & Vilstrup, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055101 · Cited by 34

Cathelicidin‐related antimicrobial peptide alleviates alcoholic liver disease through inhibiting inflammasome activation

Li, F., Zhao, C., Shao, T., Liu, Y., Gu, Z., Jiang, M., Li, H., Zhang, L., Gillevet, P. M., Puri, P., et al. (2020) · The Journal of Pathology · doi:10.1002/path.5531 · Cited by 34

The impact of rifaximin on inflammation and metabolism in alcoholic hepatitis: A randomized clinical trial

Kimer, N., Meldgaard, M., Hamberg, O., Kronborg, T. M., Lund, A. M., Møller, H. J., Bendtsen, F., & Ytting, H. (2022) · PLoS ONE · doi:10.1371/journal.pone.0264278 · Cited by 34

Alteration of intestinal intraepithelial lymphocytes and increased bacterial translocation in a murine model of cirrhosis

Inamura, T., Miura, S., Tsuzuki, Y., et al. (2003) · Immunology Letters · doi:10.1016/j.imlet.2003.05.002 · Cited by 33

Intestinal iNKT cells migrate to liver and contribute to hepatocyte apoptosis during alcoholic liver disease.

Lee, K.-C., Chen, P., Maričić, I., Inamine, T., Hu, J.-J., Gong, S.-H., Sun, J. C., Dasgupta, S., Lin, H.-C., Lin, Y.-T., et al. (2019) · American Journal of Physiology - Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00269.2018 · Cited by 32

The selective PPAR-delta agonist seladelpar reduces ethanol-induced liver disease by restoring gut barrier function and bile acid homeostasis in mice

Chu, H., Jiang, L., Gao, B., Gautam, N., Alamoudi, J. A., Lang, S., Wang, Y., Duan, Y., Alnouti, Y., Cable, E. E., et al. (2020) · Translational research · doi:10.1016/j.trsl.2020.06.006 · Cited by 32

Conventional type 1 dendritic cells protect against gut barrier disruption via maintaining Akkermansia muciniphila in alcoholic steatohepatitis

Hao, L., Zhong, W. H., Woo, J. J., Wei, X., Ma, H., Dong, H., Guo, W., Sun, X., Yue, R., Zhao, J., et al. (2023) · Hepatology · doi:10.1097/hep.0000000000000019 · Cited by 32

Gut microbiota in alcohol-related liver disease: pathophysiology and gut-brain cross talk

Zhu, L., Wang, Y., Pan, C. Q., & Xing, H. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1258062 · Cited by 32

Any alcohol use in NAFLD patients is associated with significant changes to the intestinal virome

Hsu, C. L., Lang, S., Demir, M., Fouts, D. E., Stärkel, P., & Schnabl, B. (2023) · Hepatology · doi:10.1097/hep.0000000000000238 · Cited by 31

New insights into Nod-like receptors (NLRs) in liver diseases.

Xu, T., Du, Y. Z., Xiu-bin, F., Chen, H., Zhou, D., Wang, Y., & Zhang, L. (2018) · PubMed Central · Cited by 31

TGR5 agonists for diabetes treatment: a patent review and clinical advancements (2012-present)

Bhimanwar, R. S., & Mittal, A. (2021) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2022.1994551 · Cited by 31

Effect of a specific Escherichia coli Nissle 1917 strain on minimal/mild hepatic encephalopathy treatment

Манжалій, Е., Moyseyenko, V. O., Кondratiuk, V. Y., Molochek, N., Falalyeyeva, T. M., & Kobyliak, N. M. (2022) · World Journal of Hepatology · doi:10.4254/wjh.v14.i3.634 · Cited by 31

EGF receptor plays a role in the mechanism of glutamine-mediated prevention of alcohol-induced gut barrier dysfunction and liver injury

Meena, A. S., Shukla, P. K., Sheth, P., et al. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.10.016 · Cited by 30

Beneficial Shifts in Gut Microbiota by Lacticaseibacillus rhamnosus R0011 and Lactobacillus helveticus R0052 in Alcoholic Hepatitis

Gupta, H., Kim, S. H., Kim, S. K., Han, S. H., Kwon, H. C., & Suk, K. T. (2022) · Microorganisms · doi:10.3390/microorganisms10071474 · Cited by 30

Matrisome gene-based subclassification of patients with liver fibrosis identifies clinical and molecular heterogeneities

Chen, W., Sun, Y., Chen, S., Ge, X., Zhang, W., Zhang, N., Wu, X., Song, Z., Han, H., Desert, R., et al. (2023) · Hepatology · doi:10.1097/hep.0000000000000423 · Cited by 30

Ethanol exposure drives colon location specific cell composition changes in a normal colon crypt 3D organoid model

Devall, M. A. M., Plummer, S. J., Bryant, J., Jennelle, L. T., Eaton, S. D., Dampier, C. H., Huyghe, J. R., Peters, U., Powell, S. M., & Casey, G. (2021) · Scientific Reports · doi:10.1038/s41598-020-80240-1 · Cited by 26

Liver alterations are not improved by inulin supplementation in alcohol use disorder patients during alcohol withdrawal: A pilot randomized, double-blind, placebo-controlled study

Amadieu, C., Maccioni, L., Leclercq, S., Neyrinck, A. M., Delzenne, N. M., de Timary, P., & Stärkel, P. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104033 · Cited by 26

Tributyrin Supplementation Protects Immune Responses and Vasculature and Reduces Oxidative Stress in the Proximal Colon of Mice Exposed to Chronic-Binge Ethanol Feeding

Glueck, B., Han, Y., & Cresci, G. (2018) · Journal of Immunology Research · doi:10.1155/2018/9671919 · Cited by 25

Gut‐restricted apical sodium‐dependent bile acid transporter inhibitor attenuates alcohol‐induced liver steatosis and injury in mice

Matye, D. J., Li, Y., Chen, C., Chao, X., Wang, H., Ni, H., Ding, W., & Li, T. (2021) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14619 · Cited by 25

Synbiotic Intervention Ameliorates Oxidative Stress and Gut Permeability in an In Vitro and In Vivo Model of Ethanol-Induced Intestinal Dysbiosis

Patel, D. N., Desai, C., Singh, D. R., Soppina, V., Parwani, K., Patel, F., & Mandal, P. (2022) · Biomedicines · doi:10.3390/biomedicines10123285 · Cited by 24

Duodenal CD8+ T resident memory cell apoptosis contributes to gut barrier dysfunction and microbial translocation in early alcohol‐associated liver disease in humans

Maccioni, L., Loriot, A., Dewulf, J., Bommer, G., Horsmans, Y., Lanthier, N., Leclercq, I., Schnabl, B., & Stärkel, P. (2022) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.17177 · Cited by 23

Dysregulated meta-organismal metabolism of aromatic amino acids in alcohol-associated liver disease

Mrdjen, M., Huang, E., Pathak, V., Bellar, A., Welch, N., Dasarathy, J., Streem, D. W., McClain, C. J., Mitchell, M. C., Radaeva, S., et al. (2023) · Hepatology Communications · doi:10.1097/hc9.0000000000000284 · Cited by 23

Effects of Chronic Alcohol Abuse on Duodenal Mononuclear Cells in Man

Maier, A., Bode, C., Fritz, P., & Bode, J. C. (1999) · Digestive Diseases and Sciences · doi:10.1023/a:1026697305769 · Cited by 23

Genetic Loss of Immunoglobulin A Does Not Influence Development of Alcoholic Steatohepatitis in Mice

Inamine, T., Yang, A., Wang, L., Lee, K., Llorente, C., & Schnabl, B. (2016) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13239 · Cited by 23

Machine Learning Applied to Omics Datasets Predicts Mortality in Patients with Alcoholic Hepatitis

Gao, B., Wu, T.-C., Lang, S., Jiang, L., Duan, Y., Fouts, D. E., Zhang, X., Tu, X.-M., & Schnabl, B. (2022) · Metabolites · doi:10.3390/metabo12010041 · Cited by 23

Recent insight into the role of macrophage in alcohol-associated liver disease: a mini-review

Sun, J., Zhao, P., Shi, Y., & Li, Y. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1292016 · Cited by 23

Alcohol‐associated capillarization of sinusoids: A critique since the discovery by Schaffner and Popper in 1963

Mak, K. M., Kee, D. P., & Shin, D. W. (2021) · The Anatomical Record · doi:10.1002/ar.24829 · Cited by 22

Chronic alcohol consumption regulates the expression of poly immunoglobulin receptor (pIgR) and secretory IgA in the gut

López, M. C. (2017) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2017.08.013 · Cited by 22

Deficiency of Intestinal α1‐2‐Fucosylation Exacerbates Ethanol‐Induced Liver Disease in Mice

Zhou, R., Llorente, C., Cao, J., Gao, B., Duan, Y., Jiang, L., Wang, Y., Kumar, V., Stärkel, P., Bode, L., et al. (2020) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14405 · Cited by 22

Alterations in mouse Peyer's patch lymphocyte phenotype after ethanol consumption

López, M. C., Watzl, B., Colombo, L. L., et al. (1997) · Alcohol · doi:10.1016/s0741-8329(96)00104-8 · Cited by 21

Alcohol‐associated intestinal dysbiosis alters mucosal‐associated invariant T‐cell phenotype and function

Gu, M., Samuelson, D. R., Taylor, C. M., Molina, P. E., Luo, M., Siggins, R. W., Shellito, J. E., & Welsh, D. A. (2021) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14589 · Cited by 21

Transcriptomic Profiling Identifies Novel Hepatic and Intestinal Genes Following Chronic Plus Binge Ethanol Feeding in Mice

Jiang, L., Chu, H., Gao, B., Lang, S., Wang, Y., Duan, Y., & Schnabl, B. (2020) · Digestive Diseases and Sciences · doi:10.1007/s10620-020-06461-6 · Cited by 20

Single-Cell RNA Transcriptome Profiling of Liver Cells of Short-Term Alcoholic Liver Injury in Mice

Cao, L., Wu, D., Qin, L., Tan, D., Fan, Q., Jia, X., Yang, M., Zhou, T., Feng, C., Lu, Y., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054344 · Cited by 20

The Role of Intestinal Fungi and Its Metabolites in Chronic Liver Diseases

You, N., Zhuo, L., Zhou, J., Song, Y., & Shi, J. (2019) · Gut and Liver · doi:10.5009/gnl18579 · Cited by 19

ScRNA-seq and ST-seq in liver research

He, J., Deng, C., Krall, L., & Shan, Z. (2023) · Cell Regeneration · doi:10.1186/s13619-022-00152-5 · Cited by 18

Binge alcohol alters PNPLA3 levels in liver through epigenetic mechanism involving histone H3 acetylation

Restrepo, R. J., Lim, R. W., Korthuis, R. J., & Shukla, S. D. (2017) · Alcohol · doi:10.1016/j.alcohol.2017.01.009 · Cited by 18

Human Beta Defensin 2 Ameliorated Alcohol-Associated Liver Disease in Mice

Warner, J. B., Larsen, I., Hardesty, J., Song, Y., Warner, D. R., McClain, C. J., Sun, R., Deng, Z., Jensen, B. A. H., & Kirpich, I. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2021.812882 · Cited by 18

Neuropeptides in the duodenal mucosa of chronic alcoholic heavy drinkers

Hauge, T. (2001) · Alcohol and Alcoholism · doi:10.1093/alcalc/36.3.213 · Cited by 17

Effects of ethanol on gut-associated lymphoid tissues in a model of bacterial translocation: a possible role of apoptosis

de Souza, H. S. P., Elia, C. C. S., Bráulio, V. B., et al. (2003) · Alcohol · doi:10.1016/s0741-8329(03)00134-4 · Cited by 17

Cellular crosstalk during cholestatic liver injury

Thomson, J., Hargrove, L. A., Kennedy, L. L., Demieville, J., & Francis, H. (2017) · Liver Research · doi:10.1016/j.livres.2017.05.002 · Cited by 17

Significance of Markers of Monocyte Activation (CD163 and sCD14) and Inflammation (IL‐6) in Patients Admitted for Alcohol Use Disorder Treatment

García‐Calvo, X., Bolao, F., Sanvisens, A., Zuluaga, P., Tor, J., Muga, R., & Fuster, D. (2019) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14228 · Cited by 17

Pathogenesis of Alcoholic Fatty Liver a Narrative ReviewPreprint

Seitz, H. K., Moreira, B., & Neuman, M. G. (2023) · Preprints.org · doi:10.20944/preprints202305.0606.v1 · Cited by 17

Brain GABA levels are reduced in alcoholic liver disease: A proton magnetic resonance spectroscopy study

Morley, K. C., Lagopoulos, J., Logge, W., Baillie, A., Adams, C., & Haber, P. (2018) · Addiction Biology · doi:10.1111/adb.12702 · Cited by 16

Promoting intestinal antimicrobial defense and microbiome symbiosis contributes to IL-22-mediated protection against alcoholic hepatitis in mice

Yue, R., Wei, X., Hao, L., Dong, H., Guo, W., Sun, X., Zhao, J., Zhou, Z., & Zhong, W. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1289356 · Cited by 16

Alcohol Use Is Associated With Intestinal Dysbiosis and Dysfunctional CD8+ T-Cell Phenotypes in Persons With Human Immunodeficiency Virus

Maffei, V. J., Siggins, R. W., Luo, M., Brashear, M. M., Mercante, D. E., Taylor, C. M., Molina, P. E., & Welsh, D. A. (2020) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiaa461 · Cited by 15

Dysregulation of innate cell types in the hepatic immune microenvironment of alcoholic liver cirrhosis

Ren, A., He, W., Rao, J., Ye, D., Cheng, P., Qian, J., Fu, Z., Zhang, X., Deng, R., Gao, Y., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1034356 · Cited by 15

Blood Biomarkers of Intestinal Epithelium Damage Regenerating Islet‐derived Protein 3α and Trefoil Factor 3 Are Persistently Elevated in Patients with Alcoholic Hepatitis

Yang, J., Syed, F., Xia, Y., Sanyal, A. J., Shah, V. H., Chalasani, N., Zheng, X., Yu, Q., Lou, Y., & Li, W. (2021) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14579 · Cited by 14

Ambiguous Pathogenic Roles of Macrophages in Alcohol-Associated Liver Diseases

Ahmed, Y. A., Lafdil, F., & Tacke, F. (2023) · Hepatic Medicine Evidence and Research · doi:10.2147/hmer.s326468 · Cited by 14

An update on the genetics of alcoholic liver disease

Vishnubhotla, R., Kulkarni, A. V., Sharma, M., Rao, P. N., & Reddy, D. N. (2022) · Frontiers in Gastroenterology · doi:10.3389/fgstr.2022.1030399 · Cited by 13

Membrane-bound O-acyltransferase 7 (MBOAT7) shapes lysosomal lipid homeostasis and function to control alcohol-associated liver injury

Varadharajan, V., Ramachandiran, I., Massey, W. J., Jain, R., Banerjee, R., Horak, A. J., McMullen, M. R., Huang, E., Bellar, A., Lorkowski, S. W., et al. (2024) · eLife · doi:10.7554/elife.92243.3 · Cited by 12

Immune dysregulation and pathophysiology of alcohol consumption and alcoholic liver disease

Martínez‐Castillo, M., Altamirano-Mendoza, I., Sánchez-Valle, S., García-Islas, L., Sánchez-Barragán, M., Hernandez-Santillan, M., Hernández-Barragán, A., Pérez-Hernández, J. L., la Tijera, F. H., & Gutiérrez‐Reyes, G. (2023) · Revista de Gastroenterología de México (English Edition) · doi:10.1016/j.rgmxen.2023.03.003 · Cited by 11

Chronic Binge Alcohol Administration Increases Intestinal T-Cell Proliferation and Turnover in Rhesus Macaques

Veazey, R. S., Amedee, A. M., Wang, X., et al. (2015) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12784 · Cited by 10

Decreased somatostatin is related to the hypersensitivity of intestinal epithelia to LPS via upregulated TLR4–TBK1 pathway in rats chronically exposed to ethanol

Zhou, C., Li, J., Wang, H., et al. (2009) · Alcohol · doi:10.1016/j.alcohol.2009.03.002 · Cited by 10

Critical Role of Dendritic Cells in T Cell Retention in the Interfollicular Region of Peyer’s Patches

Obata, T., Shibata, N., Goto, Y., Ishikawa, I., Sato, S., Kunisawa, J., & Kiyono, H. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1200636 · Cited by 10

MyD88 in hepatic stellate cells promotes the development of alcoholic fatty liver via the AKT pathway

Li, Y., Wei, M., Yuan, Q., Liu, Y., Tian, T., Hou, L., & Zhang, J. (2022) · Journal of Molecular Medicine · doi:10.1007/s00109-022-02196-1 · Cited by 10

Dietary Stimuli, Intestinal Bacteria and Peptide Hormones Regulate Female Drosophila Defecation Rate

Kotronarou, K., Charalambous, A., Evangelou, A., Georgiou, O., Demetriou, A., & Apidianakis, Y. (2023) · Metabolites · doi:10.3390/metabo13020264 · Cited by 10

Membrane-bound O-acyltransferase 7 (MBOAT7) shapes lysosomal lipid homeostasis and function to control alcohol-associated liver injury

Varadharajan, V., Ramachandiran, I., Massey, W. J., Jain, R., Banerjee, R., Horak, A. J., McMullen, M. R., Huang, E., Bellar, A., Lorkowski, S. W., et al. (2023) · eLife · doi:10.7554/elife.92243 · Cited by 9

Basic science to clinical trials in non-alcoholic fatty liver disease and alcohol-related liver disease: collaboration with industry

Asgharpour, A., Dinani, A. M., & Friedman, S. L. (2020) · Translational Gastroenterology and Hepatology · doi:10.21037/tgh.2020.01.04 · Cited by 8

Ultrastructural alterations in ileal M cells of rats after chronic ethanol ingestion: reversal after cessation of ethanol.

Eversole, R. R., Beuving, L. J., & Ulrich, R. (1992) · Journal of Studies on Alcohol · doi:10.15288/jsa.1992.53.519 · Cited by 8

Single-cell transcriptomics of peripheral blood mononuclear cells indicates impaired immune and inflammatory responses in alcohol-associated hepatitis

Liu, X. S., Liu, Z., Morgan, T. R. M., & Norden‐Krichmar, T. M. (2023) · Human Immunology · doi:10.1016/j.humimm.2023.110735 · Cited by 7

Fenretinide Reduces Intestinal Mucin-2-Positive Goblet Cells in Chronic Alcohol Abuse

Melis, M., Tang, X., Mai, K., Gudas, L. J., & Trasino, S. E. (2022) · Pharmacology · doi:10.1159/000524386 · Cited by 6

Intestinal dendritic cells, gatekeepers preventing ethanol-induced liver disease

Llorente, C., Rungratanawanich, W., & Liangpunsakul, S. (2023) · Hepatology · doi:10.1097/hep.0000000000000236 · Cited by 3

New insights into an old paradigm: why IgA accumulates in alcoholic liver disease and what could be its role

Ciocan, D. M., & Turpin, W. (2023) · Gut · doi:10.1136/gutjnl-2022-329415 · Cited by 2

Opposite regulation of intestinal and intrahepatic CD8 + T cells controls alcohol-associated liver disease progression

Maccioni, L., Guan, Y., Kim, M., Parra, M. A., Peiffer, B., Fu, Y., Wang, Y., Lin, Y.-H., Mackowiak, B., Feng, D., et al. (2025) · Gut · doi:10.1136/gutjnl-2024-334412 · Cited by 21

The Influence of Alcohol Use on Outcomes in Patients Transplanted for Non-alcoholic Liver Disease

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Immune Responses to Ethanol Metabolites and Cytokine Profiles Differentiate Alcoholics with or without Liver Disease

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Liver transplantation in alcoholic liver disease

Sherman, D., & Watson, R. R. (2002) · CRC Press eBooks · doi:10.3109/9780203301388-40 · Cited by 58

S1157 Trends and In-Hospital Outcomes of Alpha-1 Antitrypsin Deficiency Liver Disease in Association with Alcohol

Sieloff, E. M., Maisano, C., Lima, N. D. A., et al. (2021) · The American Journal of Gastroenterology · doi:10.14309/01.ajg.0000778160.36395.ce

Alcohol-related liver disease: treatment controversies.

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