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Cited by 133Hibiscus Plant Research StudiesBlood Pressure and Hypertension StudiesAgricultural Practices and Plant Genetics

The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.

Effect of sour tea (Hibiscus sabdariffa L.) on arterial hypertension: a systematic review and meta-analysis of randomized controlled trials

Serban, Corina, Sahebkar, Amirhossein, Ursoniu, Sorin, Andrica, Florina, Banach, Maciej·2015·Journal of Hypertension
DOI 10.1097/hjh.0000000000000585
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Abstract

BACKGROUND: Hibiscus sabdariffa L. is a tropical wild plant rich in organic acids, polyphenols, anthocyanins, polysaccharides, and volatile constituents that are beneficial for the cardiovascular system. Hibiscus sabdariffa beverages are commonly consumed to treat arterial hypertension, yet the evidence from randomized controlled trials (RCTs) has not been fully conclusive. Therefore, we aimed to assess the potential antihypertensive effects of H. sabdariffa through systematic review of literature and meta-analysis of available RCTs. METHODS: The search included PUBMED, Cochrane Library, Scopus, and EMBASE (up to July 2014) to identify RCTs investigating the efficacy of H. sabdariffa supplementation on SBP and DBP values. Two independent reviewers extracted data on the study characteristics, methods, and outcomes. Quantitative data synthesis and meta-regression were performed using a fixed-effect model, and sensitivity analysis using leave-one-out method. Five RCTs (comprising seven treatment arms) were selected for the meta-analysis. In total, 390 participants were randomized, of whom 225 were allocated to the H. sabdariffa supplementation group and 165 to the control group in the selected studies. RESULTS: Fixed-effect meta-regression indicated a significant effect of H. sabdariffa supplementation in lowering both SBP (weighed mean difference -7.58 mmHg, 95% confidence interval -9.69 to -5.46, P < 0.00001) and DBP (weighed mean difference -3.53 mmHg, 95% confidence interval -5.16 to -1.89, P < 0.0001). These effects were inversely associated with baseline BP values, and were robust in sensitivity analyses. CONCLUSION: This meta-analysis of RCTs showed a significant effect of H. sabdariffa in lowering both SBP and DBP. Further well designed trials are necessary to validate these results.

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Crossref · 10.1097/hjh.0000000000000585

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Research works printed but not linked: 4

  1. Jadad, 1996, Assessing the quality of reports of randomized clinical trials: is blinding necessary Control Clin T, rials, 17, 1
  2. Mckay, 2009, Can hibiscus tea lower blood pressure., Agro Food Industry Hi-Tech, 20, 40
  3. Wahabi, 2010, The effectiveness of Hibiscus sabdariffa in the treatment of hypertension: a systematic review., Phytomedicine, 17, 83, 10.1016/j.phymed.2009.09.002 · DOI
  4. Michalska, 2014, Patients with prehypertension: do we have enough evidence to treat them Curr Vasc P, harmacol, 12, 586

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Metadata

Authors
Serban, C., Sahebkar, A., Ursoniu, S., Andrica, F., & Banach, M.
Affiliations
  • Mashhad University of Medical Sciences (IR)
  • Victor Babeș University of Medicine and Pharmacy Timișoara (RO)
  • Medical University of Lodz (PL)
Corresponding author
Sahebkar, Amirhossein
ORCID
Venue
Journal of Hypertension
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2015-06
Volume
33
Issue
6
Pages
1119-1127
ISSN
0263-6352 (ISSN-L)
DOI
10.1097/hjh.0000000000000585
OpenAlex
W1974105416
Cited by
133
References
53
Citations by year
2026: 5 · 2025: 11 · 2024: 9 · 2023: 11 · 2022: 17 · 2021: 19 · 2020: 17 · 2019: 16 · 2018: 5 · 2017: 9 · 2016: 9 · 2015: 3
FWCI
1.58
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Hypertension (publishedVersion)
  • PubMed (publishedVersion)
  • UWA Profiles and Research Repository (UWA) (submittedVersion)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Hibiscus Plant Research Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Agricultural Practices and Plant Genetics
Keywords
Hibiscus sabdariffa, herbal supplementation, hypertension, antihypertensive effect, systolic blood pressure, diastolic blood pressure, baseline blood pressure, cardiovascular health
MeSH terms
Antihypertensive Agents, Female, Humans, Hypertension, Male, Phytotherapy, Plant Extracts, Randomized Controlled Trials as Topic, Hibiscus, Arterial Pressure

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