The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Adherence and related cardiovascular outcomes to single pill vs. separate pill administration of antihypertensive triple-combination therapy
Open accessAbstract
Objective: To compare adherence to antihypertensive treatment between patients prescribed a three-drug single-pill combination (SPC) of perindopril/amlodipine/indapamide (P/A/I) vs. the combination of an angiotensin-converting enzyme inhibitor (ACEI), a calcium-channel blocker (CCB), and a diuretic (D) as a two-drug SPC plus a third drug given separately. Methods: Using the healthcare utilization database of the Lombardy Region (Italy), the 28 210 patients, aged at least 40 years, who were prescribed P/A/I SPC during 2015–2018 were identified and the date of the first prescription was defined as the index date. For each patient prescribed the SPC, a comparator who started ACEI/CCB/D treatment as a two-pill combination was considered. Adherence to the triple combination was assessed over the year after the index date as the proportion of the follow-up days covered by prescription (PDC). Patients who had a PDC >75% were defined as highly adherent to drug therapy. Log-binomial regression models were fitted to estimate the risk ratio of treatment adherence in relation to the drug treatment strategy. Results: About 59 and 25% of SPC and two-pill combination users showed high adherence, respectively. Compared with patients under a three-drug two-pill combination, those who were treated with the three-drug SPC had a higher propensity to be highly adherent to the triple combination (2.38, 95% confidence interval: 2.32–2.44). This was the case regardless of the sex, age, comorbidities, and number of co-treatments. Conclusions: In a real-life setting, patients under three-drug SPC exhibited more frequently a high adherence to antihypertensive treatment than those prescribed a three-drug two-pill combination.
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“Rea et al. showed 59% adherence with a fixed-dose combination versus 25% with separate tablets, reducing cardiovascular events and costs [41].”
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“Rea et al. showed 59% adherence with a fixed-dose combination versus 25% with separate tablets, reducing cardiovascular events and costs [41].”
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Cites
2021 ESC Guidelines on cardiovascular disease prevention in clinical practice
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Self-citationMedication Adherence: Its Importance in Cardiovascular Outcomes
Ho, P. M., Bryson, C. L., & Rumsfeld, J. S. (2009) · Circulation · doi:10.1161/circulationaha.108.768986 · Cited by 1,488
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Better compliance to antihypertensive medications reduces cardiovascular risk
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Mehany, O., Artner, A., Sebők, S., Hankó, B., & Zelkó, R. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15052069 · Cited by 6
Metadata
- Authors
- Rea, F., Morabito, G., Savaré, L., Pathak, A., Corrao, G., & Mancia, G.
- Affiliations
- University of Milano-Bicocca (IT)
- Human Technopole (IT)
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Rea, Federico
- Venue
- Journal of Hypertension
- Published
- 2023-07-05
- Volume
- 41
- Issue
- 9
- Pages
- 1466-1473
- ISSN
- 0263-6352 (ISSN-L)
- 1473-5598
- PMC
- PMC10399952
- OpenAlex
- W4383897312
- Cited by
- 27
- References
- 4
- Citations by year
- 2026: 9 · 2025: 10 · 2024: 8
- FWCI
- 8.38
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Journal of Hypertension (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- BOA (University of Milano-Bicocca) (submittedVersion)
- Funders
- Ministero della Salute (NET-2016-02363853)
- Servier
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Keywords
- medication adherence, single-pill combination, fixed-dose combination, ACE inhibitors, calcium channel blockers, thiazide-like diuretics, proportion of days covered, cardiovascular outcomes, antihypertensive therapy
- MeSH terms
- Adult, Angiotensin-Converting Enzyme Inhibitors, Antihypertensive Agents, Calcium Channel Blockers, Drug Combinations, Drug Therapy, Combination, Humans, Hypertension, Amlodipine, Medication Adherence
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