Increased levels of oxidative stress, subclinical inflammation, and myocardial fibrosis markers in primary aldosteronism patients
Open accessAbstract
BACKGROUND: Patients with primary aldosteronism experience greater left ventricular hypertrophy and a higher frequency of cardiovascular events than do essential hypertensive patients with comparable blood pressure levels. Aldosterone has been correlated with increased oxidative stress, endothelial inflammation, and fibrosis, particularly in patients with heart disease. AIM: To evaluate oxidative stress, subclinical endothelial inflammation, and myocardial fibrosis markers in patients with primary aldosteronism and essential hypertension. DESIGN AND INDIVIDUALS: We studied 30 primary aldosteronism patients and 70 control essential hypertensive patients, matched by age, sex and median blood pressure. For all patients, we measured the serum levels of aldosterone, plasma renin activity, malondialdehyde (MDA), xanthine oxidase, metalloproteinase-9, ultrasensitive C-reactive protein and amino terminal propeptides of type I (PINP), and type III procollagen. We also evaluated the effect of PA treatment in 19 PA individuals. RESULTS: PA patients showed elevated levels of MDA (1.70 ± 0.53 versus 0.94 ± 0.65 μmol/l, P <0.001) and PINP (81.7 ± 50.6 versus 49.7 ± 27 mg/l, P = 0.002) compared with essential hypertensive controls. We found a positive correlation between MDA, PINP, and the serum aldosterone/plasma renin activity ratio in primary aldosteronism patients. Clinically, treating primary aldosteronism patients decreased MDA and PINP levels. CONCLUSION: We detected higher levels of MDA and PINP in primary aldosteronism patients, suggesting increased oxidative stress and myocardial fibrosis in these individuals. Treating primary aldosteronism patients reduced MDA and PINP levels, which may reflect the direct effect of aldosterone greater than endothelial oxidative stress and myocardial fibrosis, possibly mediated by a mineralocorticoid receptor.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Primary aldosteronism is associated with left ventricular hypertrophy, diastolic dysfunction and heart failure, large artery stiffness, oxidative stress, widespread tissue inflammation and fibrosis, and increased resistance vessel remodeling compared with primary hypertension.
“Primary aldosteronism is also associated with left ventricular hypertrophy, diastolic dysfunction and heart failure, large artery stiffness, oxidative stress, widespread tissue inflammation and fibrosis, and increased resistance vessel remodeling compared with primary hypertension.291–293”
From Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association (2018) · cites this paper as [293]
Cites
Ridker, P. M., Hennekens, C. H., Buring, J. E., & Rifai, N. (2000) · New England Journal of Medicine · doi:10.1056/nejm200003233421202 · Cited by 5,850 · see citing works
NAD(P)H Oxidase: Role in Cardiovascular Biology and Disease
Griendling, K. K., Sorescu, D., & Ushio-Fukai, M. (2000) · Circulation Research · doi:10.1161/01.res.86.5.494 · Cited by 2,886 · see citing works
Evidence for an increased rate of cardiovascular events in patients with primary aldosteronism
Milliez, P., Girerd, X. J., Plouin, P., Blacher, J., Safar, M. E., & Mourad, J. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.01.015 · Cited by 1,541 · see citing works
Molecular Mechanisms of Myocardial Remodeling
Bernard Swynghedauw, A. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.1.215 · Cited by 1,448 · see citing works
D, E. B. M. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0800239 · Cited by 1,252 · see citing works
Zannad, F. M., Alla, F., Dousset, B., Pérez, A. J. P., & Pitt, B. (2000) · Circulation · doi:10.1161/01.cir.102.22.2700 · Cited by 946 · see citing works
Inflammation in Atherosclerosis: From Vascular Biology to Biomarker Discovery and Risk Prediction
Packard, R. R. S., & Libby, P. (2008) · Clinical Chemistry · doi:10.1373/clinchem.2007.097360 · Cited by 925 · see citing works
Pou, K. M., Massaro, J. M., Hoffmann, U., Vasan, R. S., Maurovich‐Horvat, P., Larson, M. G., Keaney, J. F., Meigs, J. B., Lipinska, I., Kathiresan, S., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.710509 · Cited by 898 · see citing works
Blankenberg, S., Rupprecht, H. J., Poirier, O., Bickel, C., Smieja, M., Hafner, G., Meyer, J., Cambien, F., & Tiret, L. (2003) · Circulation · doi:10.1161/01.cir.0000058700.41738.12 · Cited by 755 · see citing works
Mineralocorticoid excess, dietary sodium, and myocardial fibrosis.
Brilla, C. G., & Weber, K. T. (1992) · PubMed · Cited by 505 · see citing works
Primary Aldosteronism and Hypertensive Disease
Mosso, L. M., Carvajal, C. A., González, A. A., Barraza, A., Avila, F., Montero, J., Alvaro Huete, G., Alessandra Gederlini, G., & Fardella, C. (2003) · Hypertension · doi:10.1161/01.hyp.0000079505.25750.11 · Cited by 484 · see citing works
Self-citationMineralocorticoids, hypertension, and cardiac fibrosis.
Young, M. J., Fullerton, M., Dilley, R. J., & Funder, J. W. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117269 · Cited by 437 · see citing works
Sabatine, M. S., Morrow, D. A., Jablonski, K. A., Rice, M. M., Warnica, J. W., Domanski, M. J., Hsia, J., Gersh, B. J., Rifai, N., Ridker, P. M., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.649939 · Cited by 385 · see citing works
Catena, C., Colussi, G., Lapenna, R., Nadalini, E., Chiuch, A., Gianfagna, P., & Sechi, L. A. (2007) · Hypertension · doi:10.1161/hypertensionaha.107.095448 · Cited by 359 · see citing works
NADH/NADPH Oxidase and Enhanced Superoxide Production in the Mineralocorticoid Hypertensive Rat
Beswick, R. A., Dorrance, A. M., Leite, R., & Webb, R. C. (2001) · Hypertension · doi:10.1161/hy1101.093423 · Cited by 346 · see citing works
Schönbeck, U., Mach, F., Sukhova, G. K., Murphy, C., Bonnefoy, J., Fabunmi, R. P., & Libby, P. (1997) · Circulation Research · doi:10.1161/01.res.81.3.448 · Cited by 334 · see citing works
Malignant transformation‐linked imbalance: Decreased xanthine oxidase activity in hepatomas
Prajda, N., & Weber, G. F. (1975) · FEBS Letters · doi:10.1016/0014-5793(75)80385-1 · Cited by 315 · see citing works
Induction of Cardiac Fibrosis by Aldosterone
Lijnen, P. J., & Petrov, V. (2000) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2000.1129 · Cited by 259 · see citing works
Aldosterone and Vascular Inflammation
Brown, N. J. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.095489 · Cited by 253 · see citing works
Circulating Biomarkers of Collagen Metabolism in Cardiac Diseases
López, B., González, A., & Dı́ez, J. (2010) · Circulation · doi:10.1161/circulationaha.109.912774 · Cited by 252 · see citing works
Excess ldosterone Is Associated With Alterations of Myocardial Texture in Primary Aldosteronism
Rossi, G. P., Bello, V. D., Ganzaroli, C., Sacchetto, A., Cesari, M., BERTINI, A., Giorgi, D., Scognamiglio, R., Mariani, M., & Pessina, A. C. (2002) · Hypertension · doi:10.1161/01.hyp.0000023182.68420.eb · Cited by 233 · see citing works
Kameda, K. (2003) · European Heart Journal · doi:10.1016/j.ehj.2003.09.022 · Cited by 161 · see citing works
Endothelial function and hypertension
Landmesser, U., & Drexler, H. (2007) · Current Opinion in Cardiology · doi:10.1097/hco.0b013e3281ca710d · Cited by 152 · see citing works
The dynamic extracellular matrix: intervention strategies during heart failure and atherosclerosis
Heeneman, S., Cleutjens, J. P. M., Faber, B. C. G., Creemers, E. E., van Suylen, R. J., Lutgens, E., Cleutjens, K. B. J. M., & Daemen, M. J. A. P. (2003) · The Journal of Pathology · doi:10.1002/path.1395 · Cited by 131 · see citing works
Inappropriate Left Ventricular Mass in Patients With Primary Aldosteronism
Muiesan, M. L., Salvetti, M., Paini, A., Agabiti-Rosei, C., Monteduro, C., Galbassini, G., Belotti, E., Aggiusti, C., Rizzoni, D., Castellano, M., et al. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.114140 · Cited by 126 · see citing works
Cicoira, M., Rossi, A., Bonapace, S., Zanolla, L., Golia, G., Franceschini, L., Caruso, B., Marino, P. N., & Zardini, P. (2004) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2004.01.010 · Cited by 106 · see citing works
A possible association between primary aldosteronism and a lower β-cell function
Mosso, L. M., Carvajal, C. A., Maiz, A., Ortiz, E. H., Castillo, C. R., Artigas, R. A., & Fardella, C. E. (2007) · Journal of Hypertension · doi:10.1097/hjh.0b013e3282861fa4 · Cited by 94 · see citing works
Self-citationBiochemical markers of myocardial remodelling in hypertensive heart disease
González, A., López, B., Ravassa, S., Beaumont, J., Arias, T., Hermida, N., Zudaire, A., & Dı́ez, J. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn235 · Cited by 87 · see citing works
Aldosterone biosynthesis and action in vascular cells
Takeda, R., Hatakeyama, H., Takeda, Y., Iki, K., Miyamori, I., Sheng, W. P., Yamamoto, H., & Blair, I. A. (1995) · Steroids · doi:10.1016/0039-128x(94)00026-9 · Cited by 79 · see citing works
Głowińska‐Olszewska, B., & Urban, M. (2007) · Metabolism · doi:10.1016/j.metabol.2007.01.011 · Cited by 73 · see citing works
The use of collagen-derived serum peptides for the clinical assessment of hypertensive heart disease
López, B., González, A., Querejeta, R., & Dı́ez, J. (2005) · Journal of Hypertension · doi:10.1097/01.hjh.0000173780.67308.f1 · Cited by 72 · see citing works
Rajzer, M. W. (2003) · American Journal of Hypertension · doi:10.1016/s0895-7061(03)00052-9 · Cited by 63 · see citing works
Post-ischemic myocardial fibrosis occurs independent of hemodynamic changes
Tsuda, T. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(03)00519-4 · Cited by 58 · see citing works
Irita, J., Okura, T., Manabe, S., Kurata, M., MIYOSHI, K., Watanabe, S., FUKUOKA, T., & Higaki, J. (2006) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2005.08.019 · Cited by 46 · see citing works
Aldosterone as a Cardiovascular Risk Hormone
Yoshimoto, T., & Hirata, Y. (2007) · Endocrine Journal · doi:10.1507/endocrj.kr-80 · Cited by 40 · see citing works
Carvajal, C. A., Herrada, A. A., Castillo, C., Contreras, F., Stehr, C. B., Mosso, L. M., Kalergis, A. M., & Fardella, C. (2009) · Journal of Endocrinological Investigation · doi:10.1007/bf03346533 · Cited by 35 · see citing works
Self-citationCastro, P., Greig, D. P., Pérez, O., Moraga, F., Chiong, M., Dı́az-Araya, G., Padilla, I., Carolina Nazzal, N., Jalil, J., Vukasovic, J. L., et al. (2003) · The American Journal of Cardiology · doi:10.1016/s0002-9149(03)00543-5 · Cited by 35 · see citing works
Self-citationEffect of spironolactone on C-reactive protein levels in patients with heart disease
Godfrey, V., Farquharson, C. A. J., Macdonald, J. E., Yee, K.-M., & Struthers, A. D. (2006) · International Journal of Cardiology · doi:10.1016/j.ijcard.2006.05.069 · Cited by 23 · see citing works
Value of renin measurement, saralasin test, and acebutolol treatment in hypertension
Kreft, C., Ménard, J., & Corvol, P. L. (1979) · Kidney International · doi:10.1038/ki.1979.23 · Cited by 18 · see citing works
Mitogen-Activated Protein Kinases as Biomarkers of Hypertension or Cardiac Pressure Overload
Ocaranza, M. P., & Jalil, J. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.141960 · Cited by 14 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Carey, R. M., Calhoun, D. A., Bakris, G. L., Brook, R. D., Daugherty, S. L., Dennison-Himmelfarb, C. R., Egan, B. M., Flack, J. M., Gidding, S. S., Judd, E., et al. (2018) · Hypertension · doi:10.1161/hyp.0000000000000084 · Cited by 1,153 · see citing works
Savard, S., Amar, L., Plouin, P.-F., & Steichen, O. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.01060 · Cited by 505 · see citing works
Muñoz‐Durango, N., Fuentes, C., Castillo, A., González-Gómez, L. M., Vecchiola, A., Fardella, C., & Kalergis, A. M. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17070797 · Cited by 288 · see citing works
Self-citationMontezano, A. C. I., & Touyz, R. M. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5302 · Cited by 275 · see citing works
Homocysteine Induces Oxidative–Nitrative Stress in Heart of Rats: Prevention by Folic Acid
Kolling, J., Scherer, E. B. D. S., da Cunha, A. A., da Cunha, M. J., & Wyse, Â. T. D. S. (2010) · Cardiovascular Toxicology · doi:10.1007/s12012-010-9094-7 · Cited by 89 · see citing works
Wu, V., Lo, S., Chen, Y., Huang, P., Tsai, C., Liang, C., Kuo, C.-C., Kuo, Y.-S., Lee, B., Wu, E., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1135 · Cited by 86 · see citing works
Adrenalectomy reverses myocardial fibrosis in patients with primary aldosteronism
Lin, Y., Wu, X., Lee, H., Lee, J.-K., Liu, Y.-C., Chang, H.-W., Lin, C., Wu, V., Chueh, S., Lin, L., et al. (2012) · Journal of Hypertension · doi:10.1097/hjh.0b013e3283550f93 · Cited by 80 · see citing works
Queisser, N., & Schupp, N. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.05.011 · Cited by 77 · see citing works
Giusti, V. C. D., Nolly, M. B., Yeves, A. M., Caldiz, C. I., Villa‐Abrille, M. C., de Cingolani, G. E. C., Ennis, I. L., Cingolani, H. E., & Aiello, E. A. (2011) · Hypertension · doi:10.1161/hypertensionaha.111.176024 · Cited by 63 · see citing works
Oxidative stress in patients affected by primary aldosteronism
Petramala, L., Pignatelli, P., Carnevale, R., Zinnamosca, L., Marinelli, C., Settevendemmie, A., Concistrè, A., Tonnarini, G., Toma, G. D., Violi, F., et al. (2014) · Journal of Hypertension · doi:10.1097/hjh.0000000000000284 · Cited by 61 · see citing works
Modulation of Immunity and Inflammation by the Mineralocorticoid Receptor and Aldosterone
Muñoz‐Durango, N., Vecchiola, A., González-Gómez, L. M., Simón, F., Riedel, C. A., Fardella, C., & Kalergis, A. M. (2015) · BioMed Research International · doi:10.1155/2015/652738 · Cited by 59 · see citing works
Self-citationHäfner, S., Baumert, J., Emeny, R. T., Lacruz, M. E., Bidlingmaier, M., Reincke, M., Kuenzel, H., Holle, R., Rupprecht, R., & Ladwig, K. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.06.007 · Cited by 54 · see citing works
Primary Aldosteronism Screening Rates Differ with Sex, Race, and Comorbidities
Turcu, A. F., Nhan, W., Grigoryan, S., Zhang, L., Urban, C., Liu, H., Holevinski, L., & Zhao, L. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.122.025952 · Cited by 52 · see citing works
Global Research Trends on Ventricular Remodeling: A Bibliometric Analysis From 2012 to 2022
Meng, T., Wang, P., Ding, J., Du, R., Gao, J. X., Li, A., Yu, S., Liu, J., Lu, X., & He, Q. (2022) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2022.101332 · Cited by 51 · see citing works
Classic and Nonclassic Apparent Mineralocorticoid Excess Syndrome
Carvajal, C. A., Tapia-Castillo, A., Vecchiola, A., Baudrand, R. F., & Fardella, C. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgz315 · Cited by 51 · see citing works
Self-citationApproach to the Patient with Primary Aldosteronism: Utility and Limitations of Adrenal Vein Sampling
Turcu, A. F., & Auchus, R. J. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa952 · Cited by 48 · see citing works
Long-term effect of specific treatment of primary aldosteronism on carotid intima–media thickness
Holaj, R., Rosa, J., Zelinka, T., Štrauch, B., Petrák, O., Indra, T., Krátká, Z., Michalský, D., Novák, K., Wichterle, D., et al. (2014) · Journal of Hypertension · doi:10.1097/hjh.0000000000000464 · Cited by 45 · see citing works
Hung, C., Chou, C., Liao, C., Lin, Y.-T., Wu, X.-M., Chang, Y., Chen, Y.-H., Wu, V., Su, M., Ho, Y., et al. (2016) · Hypertension · doi:10.1161/hypertensionaha.115.06768 · Cited by 44 · see citing works
What can urinary exosomes tell us?
Vitorino, R. M. P., Ferreira, R. M., Guedes, S. D. M., Amado, F. M. L., & Thongboonkerd, V. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03739-w · Cited by 43 · see citing works
Kim, B., Kwak, M. K., Ahn, S. H., Kim, H., Lee, S. H., & Koh, J. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-02043 · Cited by 41 · see citing works
Ambrosino, P., Lupoli, R., Tortora, A., Cacciapuoti, M., Lupoli, G., Tarantino, P., Nasto, A., & Minno, M. N. D. D. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.01.200 · Cited by 41 · see citing works
Urinary Exosomes and Their Cargo: Potential Biomarkers for Mineralocorticoid Arterial Hypertension?
Barros, E., & Carvajal, C. A. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00230 · Cited by 39 · see citing works
Self-citationVascular Disturbances in Primary Aldosteronism: Clinical Evidence
Widimsky, J., Jr., Štrauch, B., Petrák, O., Rosa, J., Šomlóová, Z., Zelinka, T., & Holaj, R. (2012) · Kidney & Blood Pressure Research · doi:10.1159/000340031 · Cited by 34 · see citing works
Evaluation of bone health in patients with adrenal tumors
Athimulam, S., & Bancos, I. (2019) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000478 · Cited by 31 · see citing works
Primary aldosteronism: emerging trends
Galati, S.-J., Hopkins, S. M., Cheesman, K. C., Zhuk, R. A., & Levine, A. C. (2013) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2013.05.003 · Cited by 30 · see citing works
Hung, C., Chou, C., Wu, X., Chang, Y., Wu, V., Chen, Y., Chang, Y.-S., Tsai, Y., Su, M., Ho, Y., et al. (2015) · Journal of Hypertension · doi:10.1097/hjh.0000000000000619 · Cited by 30 · see citing works
Evaluation of a Best-Practice Advisory for Primary Aldosteronism Screening
Charoensri, S., Bashaw, L., Dehmlow, C. L. R., Ellies, T., Wyckoff, J., & Turcu, A. F. (2024) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2023.7389 · Cited by 28 · see citing works
Berends, A. M. A., Buitenwerf, E., Gruppen, E. G., Sluiter, W. J., Bakker, S. J. L., Connelly, M. A., Kerstens, M. N., & Dullaart, R. P. F. (2018) · Clinical Endocrinology · doi:10.1111/cen.13891 · Cited by 24 · see citing works
Wu, C., Yang, Y., Hung, S., Tsai, Y., Hu, Y.-H., Lin, Y., Chu, T., Wu, K., & Wu, V. (2015) · Scientific Reports · doi:10.1038/srep15297 · Cited by 21 · see citing works
Remde, H., Dietz, A., Emeny, R. T., Riester, A., Peters, A., Gala, T. D. L. H., Then, C., Seißler, J., Beuschlein, F., Reincke, M., et al. (2016) · Journal of Hypertension · doi:10.1097/hjh.0000000000001041 · Cited by 21 · see citing works
Manosroi, W., Phudphong, P., Atthakomol, P., & Phimphilai, M. (2022) · BMC Endocrine Disorders · doi:10.1186/s12902-022-01135-y · Cited by 20 · see citing works
Martínez‐Aguayo, A., Campino, C., Baudrand, R. F., Carvajal, C. A., García, H., Marlene Aglony, I., Bancalari, R. E., García, L. R., Loureiro, C., Vecchiola, A., et al. (2016) · Journal of Hypertension · doi:10.1097/hjh.0000000000001017 · Cited by 20 · see citing works
Self-citationBarros, E., Rigalli, J. P., Tapia-Castillo, A., Vecchiola, A., Young, M. J., Hoenderop, J. G. J., Bindels, R. J. M., Fardella, C., & Carvajal, C. A. (2021) · Endocrinology · doi:10.1210/endocr/bqab032 · Cited by 19 · see citing works
Self-citationReal-World Effectiveness of Mineralocorticoid Receptor Antagonists in Primary Aldosteronism
Tezuka, Y., & Turcu, A. F. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.625457 · Cited by 19 · see citing works
Overnutrition and the Cardiorenal Syndrome: Use of a Rodent Model to Examine Mechanisms
Whaley‐Connell, A. T., Pulakat, L., DeMarco, V. G., Hayden, M. R., Habibi, J., Henriksen, E. J., & Sowers, J. R. (2011) · Cardiorenal Medicine · doi:10.1159/000322827 · Cited by 18 · see citing works
Renin-Angiotensin System - Past, Present and Future
Tolekova, A. N. (2017) · InTech eBooks · doi:10.5772/63179 · Cited by 18 · see citing works
Wang, D., Xu, J., Chen, X., Chen, Y., Shao, S., Zhang, W., Zhu, L., Xu, T., Li, Y., & Wang, J. (2018) · American Journal of Hypertension · doi:10.1093/ajh/hpy175 · Cited by 18 · see citing works
Wang, A., Wang, Y., Liu, H., Hu, X., Li, J., Xu, H., Nie, Z., Zhang, L., & Lyu, Z. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1027841 · Cited by 19 · see citing works
Galati, S.-J. (2015) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2015.02.010 · Cited by 18 · see citing works
Chang, Y., Lee, H., Hung, C., Wu, X.-M., Lee, J., Wang, S., Liao, M., Chen, Y.-H., Wu, V., Wu, K., et al. (2014) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2014.05.062 · Cited by 17 · see citing works
Mark, P. B., Boyle, S., Zimmerli, L., McQuarrie, E. P., Delles, C., & Freel, E. M. (2013) · Journal of Human Hypertension · doi:10.1038/jhh.2013.70 · Cited by 17 · see citing works
Bone Health in Adrenal Disorders
Kim, B., Lee, S. H., & Koh, J. (2018) · Endocrinology and Metabolism · doi:10.3803/enm.2018.33.1.1 · Cited by 17 · see citing works
Badran, M., Bender, S. B., & Gozal, D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032245 · Cited by 18 · see citing works
Inflammatory Markers in Primary Aldosteronism
Šomlóová, Z., Petrák, O., Rosa, J., Štrauch, B., Indra, T., Zelinka, T., Haluzı́k, M., Zikán, V., Holaj, R., & Widimsky, J., Jr. (2016) · Physiological Research · doi:10.33549/physiolres.932994 · Cited by 16 · see citing works
Disturbances in Calcium Metabolism and Cardiomyocyte Necrosis: The Role of Calcitropic Hormones
Yusuf, J., Khan, M. U., Cheema, Y., Bhattacharya, S. K., & Weber, K. T. (2012) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2012.02.004 · Cited by 16 · see citing works
Oliveira, R. J. D. S., de Oliveira, V. N., Deconte, S. R., Calábria, L. K., Moraes, A. D. S., & Espíndola, F. S. (2014) · Diabetes and Vascular Disease Research · doi:10.1177/1479164114521643 · Cited by 16 · see citing works
Loureiro, C., Campino, C., Martínez‐Aguayo, A., Godoy, I. E., Marlene Aglony, I., Bancalari, R. E., García, H., Carvajal, C. A., & Fardella, C. (2012) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2012.04503.x · Cited by 15 · see citing works
Self-citationWu, X., Liu, Y., An, J., Li, J., Lv, W., Geng, S., & Zhang, Y. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27379 · Cited by 15 · see citing works
Moon, S. J., Jang, H. N., Kim, J. H., & Moon, M. K. (2021) · Endocrinology and Metabolism · doi:10.3803/enm.2021.1012 · Cited by 14 · see citing works
Cardiac Dysfunction in Association with Increased Inflammatory Markers in Primary Aldosteronism
Lim, J. S., Park, S., Park, S. I., Oh, Y. T., Choi, E. H., Kim, J., & Rhee, Y. (2016) · Endocrinology and Metabolism · doi:10.3803/enm.2016.31.4.567 · Cited by 14 · see citing works
Grotevendt, A., Wallaschofski, H., Reincke, M., Adolf, C., Quinkler, M. O., Nauck, M. A., Hoffmann, W. U., Rettig, R., & Hannemann, A. (2017) · Endocrine · doi:10.1007/s12020-017-1348-8 · Cited by 14 · see citing works
Regulation of the Renin-Angiotensin-Aldosterone System by Reactive Oxygen Species
Morato, M., Reina‐Couto, M., Pinho, D., Albino‐Teixeira, A., & Sousa, T. (2017) · InTech eBooks · doi:10.5772/67016 · Cited by 14 · see citing works
Carvajal, C. A., Tapia-Castillo, A., Pérez, J. A., & Fardella, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.768734 · Cited by 13 · see citing works
Self-citationLai, S., Petramala, L., Mastroluca, D., Petraglia, E., Gaeta, A. D., Indino, E. L., Panebianco, V., Ciccariello, M., Shahabadi, H., Galani, A., et al. (2016) · Medicine · doi:10.1097/md.0000000000004175 · Cited by 13 · see citing works
Gkaliagkousi, Ε., Lazaridis, A. A., Anyfanti, P., Stavropoulos, K., Imprialos, K. P., Triantafyllou, Α., Mastrogiannis, Κ., Δούμα, Σ., & Doumas, M. N. (2021) · Journal of Human Hypertension · doi:10.1038/s41371-021-00639-9 · Cited by 11 · see citing works
Blood Pressure Regulation and Pathology
Touyz, R. M. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-405206-2.00014-4 · Cited by 10 · see citing works
Kuo, C., Balakrishnan, P., Hsein, Y.-C., Wu, V., Chueh, S., Chen, Y.-M., Wu, K., Wang, M., TAIPAI group, Wu, V., et al. (2014) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/1470320313498632 · Cited by 9 · see citing works
Clinical significance of CYP11B2 immunostaining in unilateral primary aldosteronism
Viukari, M., Leijon, H., Vesterinen, T., Söderlund, S., Hämäläinen, P., Yliaska, I., Rautiainen, P., Rintamäki, R. M., Soinio, M., Pörsti, I. H., et al. (2023) · Endocrine Connections · doi:10.1530/ec-23-0344 · Cited by 8 · see citing works
Transcriptome analysis of primary aldosteronism in adrenal glands and controls.
Chu, C., Zhao, C., Zhang, Z., Wang, M., Zhang, Z., Yang, A., Ma, B., Gu, M., Cui, R., Xin, Z., et al. (2017) · PubMed Central · Cited by 8 · see citing works
A multi-centre study of neutrophil-to-lymphocyte ratio in primary aldosteronism
Libianto, R., Hu, J., Chee, M. R., Hoo, J., Lim, Y. Y., Shen, J., Li, Q., Young, M. J., Fuller, P. J., & Yang, J. (2020) · Journal of the Endocrine Society · doi:10.1210/jendso/bvaa153 · Cited by 8 · see citing works
Evolving strategies for the use of spironolactone in cardiovascular disease
Jolobe, O. M. P. (2012) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2012.11.007 · Cited by 7 · see citing works
Huang, X., Yu, S., Xiao, H., Pei, L., Chen, Y., Chen, W., Li, Y., Xiao, H., & Cao, X. (2021) · International Journal of Endocrinology · doi:10.1155/2021/6685469 · Cited by 7 · see citing works
Primary Aldosteronism, Aldosterone, and Extracellular Vesicles
Carvajal, C. A., Tapia-Castillo, A., Pérez, J. A., & Fardella, C. (2021) · Endocrinology · doi:10.1210/endocr/bqab240 · Cited by 7 · see citing works
Self-citationLiang, S., Li, Q., Lai, Q., Zhou, Y., Zhang, H., Chen, X., Yao, B., Xu, W., & Yang, X. (2021) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.62851 · Cited by 6 · see citing works
Primary aldosteronism is associated with risk of urinary bladder stones in a nationwide cohort study
Chung, M., Lin, C., Wu, M., Chen, C., Shieh, J., Chung, C., Li, C., & Yu, T. (2021) · Scientific Reports · doi:10.1038/s41598-021-86749-3 · Cited by 5 · see citing works
High-sensitive C-reactive protein in primary aldosteronism
Tanemoto, M. (2016) · Journal of Hypertension · doi:10.1097/hjh.0000000000001163 · Cited by 5 · see citing works
Primary aldosteronism — recent progress and current concepts
Kołodziejczyk‐Kruk, S., Januszewicź, W., Pęczkowska, M., Prejbisz, A., Zgliczyński, W., & Januszewicz, A. (2013) · Endokrynologia Polska · doi:10.5603/ep.2013.0011 · Cited by 3 · see citing works
Lai, X., Yang, T., Wei, C., Zhu, S., & Li, J. (2025) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/0118715303361250250119035029 · Cited by 3 · see citing works
Primary idiopathic hyperaldosteronism in clinical practice
Nv, M., & Troshina, E. A. (2012) · Obesity and metabolism · doi:10.14341/2071-8713-5122 · Cited by 3 · see citing works
Hypertension, Platelets, and Inflammatory Responses
Opie, L. H. (2014) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-014-6508-y · Cited by 3 · see citing works
Ye, Z., Okamoto, R., Ito, H., Ito, R., Moriwaki, K., Ichikawa, M., Kimena, L., Ali, Y. M., Ito, M., Gómez-Sánchez, C. E., et al. (2024) · Journal of the American Heart Association · doi:10.1161/jaha.123.032828 · Cited by 2 · see citing works
Zhang, Z., Du, Y., Zhang, F., Li, X., Rong, L., Zhu, H., Tan, J., & Huang, J. (2025) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-025-01875-6 · Cited by 1 · see citing works
Apparent Mineralocorticoid Excess
Carvajal, C. A., Tapia-Castillo, A., Uslar, T., & Fardella, C. (2023) · Endocrinology · doi:10.1007/978-3-031-27119-9_11 · Cited by 1 · see citing works
Self-citationDouble-Barreled Assault by Aldosterone and Salt on the Heart
Carey, R. M. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1985 · Cited by 1 · see citing works
Manolis, A. J. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734299250.793571584 · Cited by 1 · see citing works
Aldosterone and Cardiovascular Diseases
Tomaschitz, A., & Pilz, S. (2014) · Springer eBooks · doi:10.1007/978-1-4939-0509-6_12
Bourgeois, M. (2010) · Digital Commons - University of South Florida (University of South Florida)
Shiraishi, Y., Tanaka, H., Hayashi, T., Inui, Y., Takayama, E., Ikegami, Y., Fuse, J., Sakamoto, M., Chong, T., & Momiyama, Y. (2012) · Journal of Cardiology Cases · doi:10.1016/j.jccase.2012.09.002
Chang, Y., Lee, H., Hung, C., Wu, X.-M., Lee, J., Wang, S., Liao, M., Chen, Y.-H., Wu, V., Lin, Y., et al. (2013) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2013.01.010
RetractedKolling, J. (2011) · Americanae (AECID Library)
Remde, H., Beuschlein, F., Reincke, M., & Quinkler, M. O. (2016) · Journal of Hypertension · doi:10.1097/hjh.0000000000001162
Apparent Mineralocorticoid Excess
Carvajal, C. A., Tapia-Castillo, A., Uslar, T., & Fardella, C. (2022) · Endocrinology · doi:10.1007/978-3-030-44628-4_11-1
Self-citationMERCADO-ASIS, L. B., Gomez-Tuazon, F. C., Gan, F. R., & Malong, C. L. (2024) · Journal of Medicine University of Santo Tomas · doi:10.35460/2546-1621.2024-0044
Classic and “non-classic” apparent mineralocorticoid excess
Baudrand, R. F., Carvajal, C. A., Tapia-Castillo, A., Uslar, T., & Fardella, C. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-13825-6.00223-5
Self-citationManosroi, W., Phudphong, P., Atthakomol, P., & Phimphilai, M. (2022) · Figshare · doi:10.6084/m9.figshare.20762958
Lipid Profile in Primary Aldosteronism: Cross‐Sectional and Post‐Treatment Analyses
Yazidi, M., Abid, A., Sliman, C. B. H., Kamoun, E., Oueslati, I., Chaker, F., Khessairi, N., & Chihaoui, M. (2026) · Lipids · doi:10.1002/lipd.70051
Beyond aldosterone and renin: emerging biomarkers for diagnosing and subtyping primary aldosteronism
Libianto, R., Uniacke, C. L., Fuller, P. J., Young, M. J., & Yang, J. (2026) · Endocrine Reviews · doi:10.1210/endrev/bnag016
- Authors
- Stehr, C. B., Mellado, R., Ocaranza, M. P., Carvajal, C. A., Mosso, L., Becerra, E., Solis, M., García, L., Lavandero, S., Jalil, J., & Fardella, C. E.
- Affiliations
- Pontificia Universidad Católica de Chile (CL)
- University of Chile (CL)
- Corresponding author
- Fardella, Carlos E
- Venue
- Journal of Hypertension
- Published
- 2010-10
- Volume
- 28
- Issue
- 10
- Pages
- 2120-2126
- ISSN
- 0263-6352 (ISSN-L)
- OpenAlex
- W2023229626
- Cited by
- 88
- References
- 40
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 6 · 2021: 10 · 2020: 3 · 2019: 2 · 2018: 5 · 2017: 6 · 2016: 10 · 2015: 4 · 2014: 8 · 2013: 6 · 2012: 8
- FWCI
- 5.55
- Type
- journal article
- Language
- en
- Open access
- green
- americanae.aecid.es
- Licence
- other-oa
- Locations
- Journal of Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Americanae (AECID Library) (submittedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Universidad de Chile (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- primary aldosteronism, essential hypertension, oxidative stress, subclinical inflammation, myocardial fibrosis, malondialdehyde, aldosterone, plasma renin activity, mineralocorticoid receptor, ACE inhibitors, xanthine oxidase, MMP-9, C-reactive protein
- MeSH terms
- Adult, Aldosterone, Blood Pressure, C-Reactive Protein, Female, Fibrosis, Humans, Hyperaldosteronism, Hypertension, Inflammation, Male, Malondialdehyde, Middle Aged, Cardiomyopathies, Peptide Fragments, Procollagen, Renin, Biomarkers, Case-Control Studies, Oxidative Stress
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
