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Cited by 134Oral microbiology and periodontitis researchBlood Pressure and Hypertension StudiesCardiovascular Health and Disease Prevention

The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.

Is periodontal inflammation associated with raised blood pressure? Evidence from a National US survey

Tsakos, Georgios, Sabbah, Wael, Hingorani, Aroon D, Netuveli, Gopalakrishnan, Donos, Nikos, Watt, Richard G, D'Aiuto, Francesco·2010·Journal of Hypertension
DOI 10.1097/hjh.0b013e32833e0fe1
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Abstract

There is incomplete and inconclusive evidence for the association between periodontal disease markers and arterial blood pressure, particularly from large national epidemiological studies. This study assessed the relationship between different markers of periodontal inflammation and disease with arterial blood pressure in people aged 17 years and over in USA. We analysed data from the Third National Health and Nutrition Examination Survey on 6617 men and 7377 women who received a periodontal examination. Blood pressure was analysed in both a continuous format and a binary variable for case definition of hypertension. Periodontal disease markers (extent of gingival bleeding, pocket depth, and loss of attachment, and a case definition of periodontitis) were associated on the arterial blood pressure outcomes through a series of regression models, incrementally adjusting for confounders (demographic, inflammation markers, chronic conditions, smoking, BMI, socio-economic status). All periodontal measures had significant crude associations with SBP and hypertension. Gingival bleeding, a marker of current periodontal inflammation, was the only measure consistently and significantly associated with raised SBP and an increased odds of hypertension in the US adult population throughout the adjustment process. For a 10% greater extent of gingival bleeding, the average SBP was higher by 0.5 (0.3, 0.6) mmHg in the fully adjusted model. By referring to the general population and the whole distribution of blood pressure, not only to those at higher risk for hypertension, this association might have some important implications for clinical practice and public health strategies.

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Metadata

Authors
Tsakos, G., Sabbah, W., Hingorani, A. D., Netuveli, G., Donos, N., Watt, R. G., & D'Aiuto, F.
Affiliations
  • University College London (GB)
  • Imperial College London (GB)
Corresponding author
Tsakos, Georgios
ORCID
Venue
Journal of Hypertension
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2010-12
Volume
28
Issue
12
Pages
2386-2393
ISSN
0263-6352 (ISSN-L)
DOI
10.1097/hjh.0b013e32833e0fe1
OpenAlex
W1977223297
Cited by
134
References
52
Citations by year
2026: 3 · 2025: 3 · 2024: 8 · 2023: 7 · 2022: 15 · 2021: 15 · 2020: 16 · 2019: 8 · 2018: 7 · 2017: 5 · 2016: 8 · 2015: 10 · 2014: 7 · 2013: 9 · 2012: 4
FWCI
8.16
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Hypertension (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
  • Research Portal (King's College London) (submittedVersion)
Topics
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Keywords
periodontal inflammation, periodontal disease, hypertension, arterial blood pressure, gingival bleeding, periodontitis, probing depth, attachment loss, systolic blood pressure, NHANES
MeSH terms
Blood Pressure, Female, Health Surveys, Humans, Hypertension, Male, Periodontitis, Risk Factors, United States

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