The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Quantitative and qualitative retinal microvascular characteristics and blood pressure
Abstract
OBJECTIVE: The present study examined the effects of blood pressure on a spectrum of quantitative and qualitative retinal microvascular signs. METHODS: Retinal photographs from the Singapore Malay Eye Study, a population-based cross-sectional study of 3280 (78.7% response) persons aged 40-80 years, were analyzed. Quantitative changes in the retinal vasculature (branching angle, vascular tortuosity, fractal dimension, and vascular caliber) were measured using a semi-automated computer-based program. Qualitative signs, including focal arteriolar narrowing (FAN), arteriovenous nicking (AVN), opacification of the arteriolar wall (OAW), and retinopathy (e.g., microaneurysms, retinal hemorrhages), were assessed from photographs by trained technicians. After excluding persons with diabetes and ungradable photographs, 1913 persons provided data for this analysis. RESULTS: In multivariable linear regression models controlling for age, sex, BMI, use of antihypertensive medication, and other factors, retinal arteriolar branching asymmetry ratio, arteriolar tortuosity, venular tortuosity, fractal dimension, arteriolar caliber, venular caliber, FAN, AVN, and retinopathy were independently associated with mean arterial blood pressure. In contrast, arteriolar/venular branching angle, venular branching asymmetry ratio and OAW were not related to blood pressure. Retinal arteriolar caliber (sβ = -0.277) and FAN (sβ = 0.170) had the strongest associations with mean arterial blood pressure, and higher blood pressure levels were associated with increasing number of both quantitative and qualitative retinal vascular signs (P trend <0.001). CONCLUSION: Elevated blood pressure is associated with a spectrum of quantitative and qualitative retinal vascular signs, with the number of signs increasing with higher blood pressure levels.
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Global burden of blood-pressure-related disease, 2001
Lawes, C. M., Hoorn, S. V., & Rodgers, A. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60655-8 · Cited by 2,330
The Physiological Principle of Minimum Work: I. The Vascular System and the Cost of Blood Volume
Murray, C. D. (1926) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.12.3.207 · Cited by 2,087
Impact of High-Normal Blood Pressure on the Risk of Cardiovascular Disease
Vasan, R. S., Larson, M. G., Leip, E. P., Evans, J. C., O'Donnell, C. J., Kannel, W. B., & Levy, D. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa003417 · Cited by 2,082
Hubbard, L. D., Brothers, R. J., King, W. N., Clegg, L. X., Klein, R., Cooper, L. S., Sharrett, A. R., Davis, M. D., & Cai, J. (1999) · Ophthalmology · doi:10.1016/s0161-6420(99)90525-0 · Cited by 1,184
Self-citationRevised formulas for summarizing retinal vessel diameters
Knudtson, M. D., Lee, K. E., Hubbard, L. D., Wong, T. Y., Klein, R., & Klein, B. E. K. (2003) · Current Eye Research · doi:10.1076/ceyr.27.3.143.16049 · Cited by 872
Self-citationWong, T. Y., Klein, R., Sharrett, A. R., Duncan, B. B., Couper, D. J., Tielsch, J. M., Klein, B. E. K., & Hubbard, L. D. (2002) · JAMA · doi:10.1001/jama.287.9.1153 · Cited by 795
Self-citationWong, T. Y., Klein, R., Couper, D. J., Cooper, L. S., Shahar, E., Hubbard, L. D., Wofford, M. R., & Sharrett, A. R. (2001) · The Lancet · doi:10.1016/s0140-6736(01)06253-5 · Cited by 781
Self-citationWong, T. Y., & Mitchell, P. (2004) · New England Journal of Medicine · doi:10.1056/nejmra032865 · Cited by 696
Self-citationMicrocirculation in Hypertension: A New Target for Treatment?
Levy, B. I., Ambrosio, G., Pries, A. R., & Struijker-Boudier, H. A. J. (2001) · Circulation · doi:10.1161/hc3101.091158 · Cited by 637
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Metadata
- Authors
- Cheung, C. Y., Tay, W. T., Mitchell, P., Wang, J. J., Hsu, W., Lee, M. L., Lau, Q. P., Zhu, A. L., Klein, R., Saw, S. M., & Wong, T. Y.
- Venue
- Journal of Hypertension
- Published
- 2011-07
- Volume
- 29
- Issue
- 7
- Pages
- 1380-1391
- ISSN
- 0263-6352 (ISSN-L)
- OpenAlex
- W2038231403
- Cited by
- 255
- References
- 54
- FWCI
- 14.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- Cheung, C. Y., Tay, W. T., Mitchell, P., Wang, J. J., Hsu, W., Lee, M. L., Lau, Q. P., Zhu, A. L., Klein, R., Saw, S. M., & Wong, T. Y. (2011). Quantitative and qualitative retinal microvascular characteristics and blood pressure. Journal of Hypertension. https://doi.org/10.1097/hjh.0b013e328347266c
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