The DOI matches its Crossref record; 230 of the 230 references it cites were found in a registry or an index.
Psychiatric Symptoms Across the Menstrual Cycle in Adult Women: A Comprehensive Review
Open accessAbstract
LEARNING OBJECTIVE: After participating in this activity, learners should be better able to:• Discuss and outline the general and overlapping effects of the menstrual cycle on women's mental health. ABSTRACT: A growing body of research demonstrates menstrual cycle-dependent fluctuations in psychiatric symptoms; these fluctuations can therefore be considered as prevalent phenomena. Possible mechanisms underlying these fluctuations posit behavioral, psychological, and neuroendocrine influences. Recent reviews document cyclic exacerbation of symptoms and explore these mechanisms in the context of specific and often single disorders. The question remains, however, as to whether there are general and overlapping effects of the menstrual cycle on women's mental health. To address this gap, we synthesized the literature examining the exacerbation of a variety of psychiatric symptoms across the menstrual cycle in adult women. Results show that the premenstrual and menstrual phases are most consistently implicated in transdiagnostic symptom exacerbation. Specifically, strong evidence indicates increases in psychosis, mania, depression, suicide/suicide attempts, and alcohol use during these phases. Anxiety, stress, and binge eating appear to be elevated more generally throughout the luteal phase. The subjective effects of smoking and cocaine use are reduced during the luteal phase, but fewer data are available for other substances. Less consistent patterns are demonstrated for panic disorder, symptoms of posttraumatic stress disorder, and borderline personality disorder, and it is difficult to draw conclusions for symptoms of generalized anxiety disorder, social anxiety disorder, obsessive-compulsive disorder, and trichotillomania because of the limited data. Future research should focus on developing standardized approaches to identifying menstrual cycle phases and adapting pharmacological and behavioral interventions for managing fluctuations in psychiatric symptoms across the menstrual cycle.
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“For women [18], and women with ADHD especially [19,20], the menstrual cycle probably influences these symptoms.”
From A Female-Specific Treatment Group for ADHD—Description of the Programme and Qualitative Analysis of First Experiences (2024) · cites this paper as [18]
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Cites
False Suffocation Alarms, Spontaneous Panics, and Related Conditions: An Integrative Hypothesis
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Why Are Self-Report and Behavioral Measures Weakly Correlated?
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Menstrual cycle phase modulates reward-related neural function in women
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How to study the menstrual cycle: Practical tools and recommendations
Schmalenberger, K. M., Tauseef, H. A., Barone, J., Owens, S., Lieberman, L., Jarczok, M. N., Girdler, S. S., Kiesner, J., Ditzen, B., & Eisenlohr-Moul, T. A. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.104895 · Cited by 429
Variability in the phases of the menstrual cycle
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Research works printed but not linked: 2
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- 2002, Physiological and psychological reactivity in women with asthma: the effects of anxiety and menstrual cycle phase, Behav Res Ther, 40, 3
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Skoglund, C., Sundström Poromaa, I., Leksell, D., Ekholm Selling, K., Cars, T., Giacobini, M., Young, S., & Kopp Kallner, H. (2024) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13920 · Cited by 77
de Jong, M., Wynchank, D. S. M. R., Michielsen, M., Beekman, A. T. F., & Kooij, J. J. S. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13072106 · Cited by 11
Metadata
- Authors
- Handy, A. B., Greenfield, S. F., Yonkers, K. A., & Payne, L. A.
- Affiliations
- Harvard University (US)
- Corresponding author
- Payne, Laura A.
- Venue
- Harvard Review of Psychiatry
- Published
- 2022-03
- Volume
- 30
- Issue
- 2
- Pages
- 100-117
- ISSN
- 1067-3229 (ISSN-L)
- 1465-7309
- PMC
- PMC8906247
- OpenAlex
- W4220970268
- Cited by
- 153
- References
- 230
- Citations by year
- 2026: 44 · 2025: 46 · 2024: 30 · 2023: 27 · 2022: 6
- FWCI
- 5.42
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Harvard Review of Psychiatry (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Menstrual Health and Disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Keywords
- menstrual cycle, psychiatric symptoms, premenstrual phase, luteal phase, women's mental health, transdiagnostic symptoms, psychosis, mania, depression, suicide, alcohol consumption, anxiety, binge eating, substance use, post-traumatic stress disorder, borderline personality disorder, neuroendocrine mechanisms
- MeSH terms
- Adult, Anxiety, Anxiety Disorders, Female, Humans, Menstrual Cycle, Smoking, Stress Disorders, Post-Traumatic
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