SUBFOVEAL CHOROIDAL THICKNESS IN FELLOW EYES OF PATIENTS WITH CENTRAL SEROUS CHORIORETINOPATHY

Abstract

In Brief Purpose: To evaluate the subfoveal choroidal thickness in the fellow eyes of patients with CSC, a disease often associated with choroidal vascular hyperpermeability even in eyes without subretinal fluid. Methods: In this observational cross-sectional study, we measured the bilateral subfoveal choroidal thickness in patients with unilateral CSC using enhanced depth imaging spectral-domain optical coherence tomography. Areas of choroidal vascular hyperpermeability were visualized with indocyanine green angiography. Results: Sixty-six consecutive Japanese patients (50 men, 16 women; mean age, 52.8 years) with unilateral CSC were examined. The subfoveal choroid in symptomatic eyes was significantly thicker than that in fellow eye (414 ± 109 μm vs. 350 ± 116 μm, P < 0.001, respectively). The subfoveal choroid of eyes with choroidal vascular hyperpermeability was 410 ± 92 μm, which differed significantly (P < 0.001) from the choroid (239 ± 59 μm) of fellow eyes without choroidal vascular hyperpermeability. Conclusion: The subfoveal choroid in the fellow eyes of patients with CSC was thicker in the eyes with choroidal vascular hyperpermeability. Enhanced depth imaging spectral-domain optical coherence tomography can assess the effects of choroidal vascular hyperpermeability by measuring the choroidal thickness noninvasively. The subfoveal choroid measured by enhanced depth imaging spectral-domain optical coherence tomography in the fellow eyes of patients with central serous chorioretinopathy (CSC) is thicker in eyes with choroidal vascular hyperpermeability on indocyanine green angiography. Enhanced depth imaging spectral-domain optical coherence tomography can evaluate choroidal vascular hyperpermeability noninvasively.