The DOI matches its Crossref record; 21 of the 26 references it cites were found in a registry or an index, and 3 are not checked yet.
FGF-2 Angiogenesis in Bone Regeneration Within Critical-Sized Bone Defects in Rat Calvaria
Abstract
OBJECTIVE: This study examined the effect of basic fibroblast growth factor (FGF)-2 with an absorbable collagen sponge on angiogenesis and bone regeneration in rat calvarial critical-sized bone defects using microcomputed tomography. METHODS: Forty 7-week-old male Fischer rats were used. The symmetrical critical-sized calvarial bone defects (5 mm diameter) were created. An absorbable collagen sponge with or without FGF-2 (0.1% or 0.3%) was implanted into each bone defect. RESULTS: Blood vessel and bone volumes were significantly higher in the 0.3% FGF-2 group compared with the control and 0.1% FGF-2 groups on day 28. Significantly more osteoblast- and osteoclast-like cells were seen in the 0.3% FGF-2 group. CONCLUSIONS: Thus, FGF-2 increased blood vessel and bone formation in rat calvarial critical-sized bone defects.
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In the citing paper
“Among these, major regulators within the bone remodeling cascade are bone morphogenetic proteins (BMPs), vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), platelet-derived growth factor (PDGF), transforming growth factor-β1 (TGF-β1), and insulin-like growth factor 1 (IGF-1) [39,69,70,71,72,73,74,75,76].”
From Mesenchymal Stem/Stromal Cells: Immunomodulatory and Bone Regeneration Potential after Tumor Excision in Osteosarcoma Patients (2023) · cites this paper as [73]
In the citing paper
“Following bone injury, the bone’s extracellular matrix releases a physiological amount of growth factors which play a vital role in bone repair.”
From Mesenchymal Stem/Stromal Cells: Immunomodulatory and Bone Regeneration Potential after Tumor Excision in Osteosarcoma Patients (2023) · cites this paper as [73]
In the citing paper
“Also, FGF, especially FGF-2, plays a role in angiogenesis and bone regeneration.”
From Mesenchymal Stem/Stromal Cells: Immunomodulatory and Bone Regeneration Potential after Tumor Excision in Osteosarcoma Patients (2023) · cites this paper as [73]
In the citing paper
“Studies administering FGF-2 to rat calvarial defects via a collagen sponge have demonstrated augmented osteoblast differentiation, increased blood vessel formation, and higher bone volume generation based on FGF-2 concentrations [39,73].”
From Mesenchymal Stem/Stromal Cells: Immunomodulatory and Bone Regeneration Potential after Tumor Excision in Osteosarcoma Patients (2023) · cites this paper as [73]
Citations
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Biological Roles of Fibroblast Growth Factor-2
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Tissue Engineering and Cell-Based Therapies for Fractures and Bone Defects
Perez, J. R., Kouroupis, D., Li, D. J., Best, T. M., Kaplan, L., & Correa, D. (2018) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2018.00105 · Cited by 390
Biomimetic delivery of signals for bone tissue engineering
Dang, M., Saunders, L. R., Niu, X., Fan, Y., & Ma, P. X. (2018) · Bone Research · doi:10.1038/s41413-018-0025-8 · Cited by 244
The Effect of Exercise on the Prevention of Osteoporosis and Bone Angiogenesis
Tong, X., Chen, X., Zhang, S., Huang, M., Shen, X., Xu, J., & Zou, J. (2019) · BioMed Research International · doi:10.1155/2019/8171897 · Cited by 158
EPO Promotes Bone Repair through Enhanced Cartilaginous Callus Formation and Angiogenesis
Lin, W., Zhang, F., He, Q., Tsang, W. P., Lu, L., Li, Q., Wu, Z., Qiu, G., Zhou, G., & Wan, C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102010 · Cited by 76
The Potential of FGF-2 in Craniofacial Bone Tissue Engineering: A Review
Novais, A., Chatzopoulou, E., Chaussain, C., & Gorin, C. (2021) · Cells · doi:10.3390/cells10040932 · Cited by 71
Metadata
- Authors
- Kigami, R., Sato, S., Tsuchiya, N., Yoshimakai, T., Arai, Y., & Ito, K.
- Affiliations
- Nihon University (JP)
- Corresponding author
- Kigami, Risa
- Tsuchiya, Noriko
- Yoshimakai, Tomohiro
- Venue
- Implant Dentistry
- Published
- 2013-08
- Volume
- 22
- Issue
- 4
- Pages
- 422-427
- ISSN
- 1056-6163 (ISSN-L)
- OpenAlex
- W2021429147
- Cited by
- 46
- References
- 26
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 4 · 2020: 2 · 2019: 4 · 2018: 6 · 2017: 2 · 2016: 5 · 2015: 5 · 2014: 3 · 2013: 3
- FWCI
- 2.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Implant Dentistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (25463056)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Health Sciences › Dentistry › Periodontics › Periodontal Regeneration and Treatments
- Health Sciences › Dentistry › Oral Surgery › Dental Implant Techniques and Outcomes
- Keywords
- basic fibroblast growth factor, angiogenesis, bone regeneration, critical-size bone defect, calvaria, absorbable collagen sponge, bone formation, osteoblasts, osteoclasts
- MeSH terms
- Animals, Bone Diseases, Bone Regeneration, Collagen, Contrast Media, Image Processing, Computer-Assisted, Iopamidol, Male, Osteoblasts, Osteoclasts, Osteogenesis, Parietal Bone, Rats, Inbred F344, Time Factors, X-Ray Intensifying Screens, Fibroblast Growth Factor 2, Neovascularization, Physiologic, Absorbable Implants, Tissue Engineering, Rats, Tissue Scaffolds, X-Ray Microtomography, Microvessels
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- CoChat. (2026). Citation check: FGF-2 Angiogenesis in Bone Regeneration Within Critical-Sized Bone Defects in Rat Calvaria. https://app.cochat.ai/papers/10.1097/id.0b013e31829d19f0
- The paper
- Kigami, R., Sato, S., Tsuchiya, N., Yoshimakai, T., Arai, Y., & Ito, K. (2013). FGF-2 Angiogenesis in Bone Regeneration Within Critical-Sized Bone Defects in Rat Calvaria. Implant Dentistry. https://doi.org/10.1097/id.0b013e31829d19f0
