The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Procalcitonin and C-Reactive Protein as Diagnostic Markers of Severe Bacterial Infections in Febrile Infants and Children in the Emergency Department
Open accessAbstract
OBJECTIVE: To assess the value of procalcitonin (PCT) and C-reactive protein (CRP), compared with that of total white-blood cell count (WBC) and absolute neutrophil count (ANC), in predicting severe bacterial infections (SBIs) in febrile children admitted to Emergency Department. METHODS: A prospective study was conducted in 408 children aged 7-days to 36-months, admitted with fever without source, at a tertiary care Pediatric Emergency Department. PCT, CRP, WBC, and ANC were determined upon admission and compared. Specificity, sensitivity, multilevel likelihood ratios, receiver operating characteristic (ROC) analysis, and multivariate stepwise logistic regression were carried out. RESULTS: SBI was diagnosed in 94 children (23.1%). PCT, CRP, WBC, and ANC were significantly higher in this group than in non-SBI patients. The area under the ROC (AUC) obtained was 0.82 (95% CI: 0.78-0.86) for PCT, 0.85 (95% CI: 0.81-0.88) for CRP (P = 0.358), 0.71 (95% CI: 0.66-0.75) for WBC, and 0.74 (95% CI: 0.70-0.78) for ANC. Only PCT (OR: 1.32; 95% CI: 1.11-1.57; P < 0.001) and CRP (OR: 1.02; 95% CI: 1.01-1.03; P < 0.001) were retained as significant predictors of SBI in a multiple regression model. For infants with fever <8 hours (n = 45), AUC for PCT and CRP were 0.92 (95% CI: 0.80-0.98) and 0.75 (95% CI: 0.60-0.87), respectively (P = 0.056). CONCLUSION: Both PCT and CRP are valuable markers in predicting SBI in children with fever without source and they perform better than WBC and ANC. PCT appears more accurate at the beginning of infections, but overall CRP may be the most convenient marker for its better sensitivity and feasibility.
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2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
Levy, M. M., Fink, M. P., Marshall, J. C., Abraham, E., Angus, D., Cook, D., Cohen, J., Opal, S. M., Vincent, J.-L., & Ramsay, G. (2003) · Critical Care Medicine · doi:10.1097/01.ccm.0000050454.01978.3b · Cited by 5,995
Whitney, C. G., Farley, M. M., Hadler, J., Harrison, L. H., Bennett, N. M., Lynfield, R., Reingold, A., Cieslak, P. R., Pilishvili, T., Jackson, D., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022823 · Cited by 2,228
High serum procalcitonin concentrations in patients with sepsis and infection
Assicot, M., Bohuon, C., Gendrel, D., Raymond, J., Carsin, H., & Guilbaud, J. (1993) · The Lancet · doi:10.1016/0140-6736(93)90277-n · Cited by 2,197
Procalcitonin increase after endotoxin injection in normal subjects
Dandona, P. (1994) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.79.6.1605 · Cited by 965
Function of C-reactive protein
Du Clos, T. W. (2000) · Annals of Medicine · doi:10.3109/07853890009011772 · Cited by 801
Clinical applications of C-reactive protein in pediatrics
JAYE, D. L., & WAITES, K. B. (1997) · The Pediatric Infectious Disease Journal · doi:10.1097/00006454-199708000-00003 · Cited by 398
Observation Scales to Identify Serious Illness in Febrile Children
McCarthy, P. L., Sharpe, M. R., Spiesel, S. Z., Dolan, T. F., Forsyth, B. W., DeWitt, T. G., Fink, H. D., Baron, M. A., & Cicchetti, D. V. (1982) · Pediatrics · doi:10.1542/peds.70.5.802 · Cited by 358
Procalcitonin as an early marker of infection in neonates and children
van Rossum, A., Wulkan, R., & Oudesluys-Murphy, A. (2004) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(04)01146-6 · Cited by 310
Management of fever without source in infants and children
Baraff, L. J. (2000) · Annals of Emergency Medicine · doi:10.1067/mem.2000.110820 · Cited by 307
Baraff, L. J., Schriger, D. L., Bass, J. W., Fleisher, G. R., Klein, J. O., McCracken, G. H., & Powell, K. R. (1993) · Pediatrics · doi:10.1542/peds.92.1.1 · Cited by 278
Cited by
Evaluation and Management of Well-Appearing Febrile Infants 8 to 60 Days Old
Pantell, R. H., Roberts, K. B., Adams, W. G., Dreyer, B. P., Kuppermann, N., O’Leary, S. T., Okechukwu, K., Woods, C. R., Byington, C. L., Lavelle, J. M., et al. (2021) · Pediatrics · doi:10.1542/peds.2021-052228 · Cited by 444
Van den Bruel, A., Haj-Hassan, T., Thompson, M., Buntinx, F., & Mant, D. (2010) · The Lancet · doi:10.1016/s0140-6736(09)62000-6 · Cited by 317
Van den Bruel, A., Thompson, M. J., Haj-Hassan, T., Stevens, R., Moll, H., Lakhanpaul, M., & Mant, D. (2011) · BMJ · doi:10.1136/bmj.d3082 · Cited by 324
Evaluation and Management of Febrile, Well-appearing Young Infants
Biondi, E. A., & Byington, C. L. (2015) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2015.05.008 · Cited by 60
Metadata
- Authors
- Andreola, B., Bressan, S., Callegaro, S., Liverani, A., Plebani, M., & Da Dalt, L.
- Venue
- Pediatric Infectious Disease Journal
- Published
- 2007-08
- Volume
- 26
- Issue
- 8
- Pages
- 672-677
- ISSN
- 0891-3668 (ISSN-L)
- OpenAlex
- W2021629682
- Cited by
- 271
- References
- 28
- FWCI
- 8.17
- Type
- journal article
- Language
- en
- Open access
- green
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- Andreola, B., Bressan, S., Callegaro, S., Liverani, A., Plebani, M., & Da Dalt, L. (2007). Procalcitonin and C-Reactive Protein as Diagnostic Markers of Severe Bacterial Infections in Febrile Infants and Children in the Emergency Department. Pediatric Infectious Disease Journal. https://doi.org/10.1097/inf.0b013e31806215e3
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