The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Function of C-reactive protein
Abstract
C-reactive protein (CRP) is an ancient highly conserved molecule and a member of the pentraxin family of proteins. CRP is secreted by the liver in response to a variety of inflammatory cytokines. Levels of CRP increase very rapidly in response to trauma, inflammation, and infection and decrease just as rapidly with the resolution of the condition. Thus, the measurement of CRP is widely used to monitor various inflammatory states. CRP binds to damaged tissue, to nuclear antigens and to certain pathogenic organisms in a calcium-dependent manner. The function of CRP is felt to be related to its role in the innate immune system. Similar to immunoglobulin (Ig)G, it activates complement, binds to Fc receptors and acts as an opsonin for various pathogens. Interaction of CRP with Fc receptors leads to the generation of proinflammatory cytokines that enhance the inflammatory response. Unlike IgG, which specifically recognizes distinct antigenic epitopes, CRP recognizes altered self and foreign molecules based on pattern recognition. Thus, CRP is though to act as a surveillance molecule for altered self and certain pathogens. This recognition provides early defense and leads to a proinflammatory signal and activation of the humoural, adaptive immune system.
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Cites
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Serum amyloid P component controls chromatin degradation and prevents antinuclear autoimmunity
Bickerstaff, M. C. M., Botto, M., Hutchinson, W. L., Herbert, J., Tennent, G. A., Bybee, A., Mitchell, D. A., Cook, H. T., Butler, P. J. G., Walport, M. J., et al. (1999) · Nature Medicine · doi:10.1038/9544 · Cited by 489
Interaction of C-Reactive Protein Complexes with the Complement System
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The Major Receptor for C-Reactive Protein on Leukocytes Is Fcγ Receptor II
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Induction of inflammatory cytokine release from cultured human monocytes by C-reactive protein
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C-reactive protein is protective against Streptococcus pneumoniae infection in mice.
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Self-citationInteraction of C-reactive protein with artificial phosphatidylcholine bilayers
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Cited by
Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis.
Howren, M. B., Lamkin, D. M., & Suls, J. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181907c1b · Cited by 2,766
Molecular inflammation: Underpinnings of aging and age-related diseases
Chung, H. Y., Cesari, M., Anton, S., Marzetti, E., Giovannini, S., Seo, A. Y., Carter, C., Yu, B. P., & Leeuwenburgh, C. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2008.07.002 · Cited by 1,203
Keel, M., & Trentz, O. (2005) · Injury · doi:10.1016/j.injury.2004.12.037 · Cited by 885
Is obesity an inflammatory condition?
Das, U. N. (2001) · Nutrition · doi:10.1016/s0899-9007(01)00672-4 · Cited by 799
Cottam, D. R., Mattar, S. G., Barinas-Mitchell, E., Eid, G., Kuller, L., Kelley, D. E., & Schauer, P. R. (2004) · Obesity Surgery · doi:10.1381/096089204323093345 · Cited by 461
Metadata
- Authors
- Du Clos, T. W.
- Venue
- Annals of Medicine
- Publisher
- Informa UK Limited
- Published
- 2000-01
- Volume
- 32
- Issue
- 4
- Pages
- 274-278
- ISSN
- 0785-3890 (ISSN-L)
- 1365-2060
- OpenAlex
- W1993060519
- Cited by
- 801
- References
- 28
- FWCI
- 8.44
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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