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Cited by 78Anesthesia and Pain ManagementPain Management and TreatmentPain Mechanisms and Treatments

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

Perioperative pregabalin administration does not prevent chronic postoperative pain: systematic review with a meta-analysis of randomized trials

Martinez, Valeria, Pichard, Xavier, Fletcher, Dominique·2017·Pain
DOI 10.1097/j.pain.0000000000000838
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Abstract

The efficacy of perioperative pregabalin treatment for preventing chronic pain remains a matter of debate. We searched the MEDLINE, EMBASE, LILACS, Cochrane, and Clinical Trial Register databases, and other sources, for randomized controlled trials comparing the effects of pregabalin and placebo. The primary outcome was the incidence of chronic postsurgical pain (CPSP) at 3 months. The secondary endpoints were CPSP at 3, 6, and 12 months and the incidence of chronic postsurgical neuropathic pain at the same time points. A random-effect meta-analysis was performed on the combined data. Evidence quality was rated by the GRADE method. We included 18 studies (2485 patients) in the meta-analysis. Overall, 60% of the trials reporting the primary outcome at 3 months were unpublished; the unpublished trials corresponded to 1492/1884 (79%) of the patients included in these studies. No difference in CPSP incidence between pregabalin and placebo was found at any time point; the risk ratio was 0.87 (0.66, 1.14), I 2 = 57% at 3 months. The evidence was considered to be of moderate quality. Subgroup analysis by publication status, daily dose, type of administration, and type of surgery did not highlight any differences between subgroups. Insufficient data concerning the incidence of chronic postsurgical neuropathic pain were available for any firm recommendation to be made. Pooled data from published and unpublished studies provide no support for the efficacy of pregabalin for preventing CPSP.

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Crossref · 10.1097/j.pain.0000000000000838

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Research works printed but not linked: 2

  1. Remerand, 2011, Benefits and safety of perioperative pregabalin: a systematic review [in French], Ann Fr Anesth Reanim, 30, 569
  2. Sidiropoulou, 2013, Perioperative pregabalin and continuouswound infiltration of local anaesthetics in patients following thoracotomy, Reg Anesth Pain Med, 38, E231

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Metadata

Authors
Martinez, V., Pichard, X., & Fletcher, D.
Affiliations
Inserm (FR)
Corresponding author
Martinez, Valeria
ORCID
Venue
Pain
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2017-02-18
Volume
158
Issue
5
Pages
775-783
ISSN
  • 0304-3959 (ISSN-L)
  • 1872-6623
DOI
10.1097/j.pain.0000000000000838
OpenAlex
W2595168535
Cited by
78
References
42
Citations by year
2026: 2 · 2025: 4 · 2024: 4 · 2023: 9 · 2022: 7 · 2021: 11 · 2020: 6 · 2019: 4 · 2018: 19 · 2017: 12
FWCI
2.38
Type
journal article
Language
en
Open access
closed
Locations
  • Pain (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Pain Management
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
  • Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Keywords
pregabalin, chronic postoperative pain, perioperative analgesia, pain prevention, unpublished trials, publication bias, surgical pain
MeSH terms
Pregabalin, Analgesics, Drug Administration Schedule, Humans, Pain, Postoperative, Postoperative Pain, Perioperative Period

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