Cited by 199Psychometric Methodologies and TestingMusculoskeletal pain and rehabilitationPain Management and Opioid Use

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Estimating minimally important differences for the PROMIS pain interference scales: results from 3 randomized clinical trials

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Chen, Chen X., Kroenke, Kurt, Stump, Timothy E., Kean, Jacob, Carpenter, Janet S., Krebs, Erin E., Bair, Matthew J., Damush, Teresa M., Monahan, Patrick O.·2018·Pain

DOI 10.1097/j.pain.0000000000001121PMC PMC5860950

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Abstract

Minimally important difference (MID) refers to the smallest meaningful difference that carries implications for patient care. Minimally important differences are necessary to help interpret patient-reported pain outcomes in research and clinical practice. The PROMIS pain interference scales were validated across diverse samples; however, more information about their MIDs could improve their interpretability. The purpose of this study was to estimate MIDs for 4 fixed-length PROMIS pain interference scales, including the 6-item Pain Short Form and the 4-, 6-, and 8-item pain interference scales used in the PROMIS profile instruments. Data were analyzed from 3 randomized controlled trials (N = 759). The 3 samples, respectively, consisted of patients with chronic low back pain (n = 261), chronic back pain or hip/knee osteoarthritis pain (n = 240), and a history of stroke (n = 258). For each sample, anchor- and distribution-based approaches were used to estimate MIDs. Standard error of measurement and effect sizes were used as distribution-based MID estimates. Anchor-based MID estimates were established by mapping PROMIS pain interference scores onto established anchor measures, including the Brief Pain Inventory, and retrospective and prospective global ratings of change. The distribution- and anchor-based MID estimates showed convergence. For the pain samples, MID estimates ranged from 2 to 3 T-score points. For the nonpain sample, MID estimates ranged from 3.5 to 4.5 T-score points. The MID estimates were comparable across the 4 fixed-length scales. These MIDs can be used to evaluate treatment effects in research and clinical care and to calculate estimates for powering clinical trials.

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Lagarde, M. M. M., Wilbraham, D., Martins, R. F., Zhao, S., Jackson, K. A., Johnson, K. W., Knopp, K. L., DiBenedetto, D. J., & Broad, L. M. (2024) · Pain · doi:10.1097/j.pain.0000000000003487 · Cited by 17
International application of PROMIS computerized adaptive tests: US versus country-specific item parameters can be consequential for individual patient scores
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Who benefits from an eHealth‐based stress management intervention in advanced prostate cancer? Results from a randomized controlled trial
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Comparative responsiveness and minimally important difference of fatigue symptom inventory (FSI) scales and the FSI-3 in trials with cancer survivors
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“For reference, clinically meaningful PROMIS score changes in patients with conservatively managed chronic musculoskeletal pain have previously been defined as 3.0 points for Anxiety, 3.2 points for Depression, 2.0 points for Pain Interference, and 2.2 points for Physical Function [45-47].”
BackgroundInfluential
Adding Centralized Electronic Patient-Reported Outcome Data Collection to an Established International Clinical Outcomes Registry
Cusatis, R. N., Flynn, K. E., Vasu, S., Pidala, J., Muffly, L. S., Uberti, J. P., Tamari, R., Mattila, D., Mussetter, A., Bruzauskas, R., et al. (2021) · Transplantation and Cellular Therapy · doi:10.1016/j.jtct.2021.10.016 · Cited by 12
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King, H. A., Doernberg, S. B., Grover, K. K., Miller, J., Oakes, M. M., Wang, T.-W., McFatrich, M., Ruffin, F., Staman, K. L., Lane, H., et al. (2021) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofab622 · Cited by 11
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Authors: Chen, C. X., Kroenke, K., Stump, T. E., Kean, J., Carpenter, J. S., Krebs, E. E., Bair, M. J., Damush, T. M., & Monahan, P. O.
Affiliations: Indiana University Indianapolis (US)
Regenstrief Institute (US)
University of Utah (US)
University of Minnesota (US)
Corresponding author: Chen, Chen X.
ORCID: Chen, Chen X.
Kroenke, Kurt
Stump, Timothy E.
Kean, Jacob
Carpenter, Janet S.
Krebs, Erin E.
Bair, Matthew J.
Damush, Teresa M.
Monahan, Patrick O.
Venue: Pain
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2017-12-01
Volume: 159
Issue: 4
Pages: 775-782
ISSN: 0304-3959 (ISSN-L)
1872-6623
DOI: 10.1097/j.pain.0000000000001121
PMC: PMC5860950
OpenAlex: W2773505783
Cited by: 199
References: 28
Citations by year: 2026: 21 · 2025: 22 · 2024: 12 · 2023: 32 · 2022: 42 · 2021: 21 · 2020: 27 · 2019: 13 · 2018: 9
FWCI: 11.84
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Pain (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
IUScholarWorks (Indiana University) (submittedVersion)
Purdue University Indianapolis (Indiana University) (submittedVersion)
Funders: U.S. Department of Veterans Affairs (I01 HX000587, I01 HX000495, IK2 RX000879, I01 HX000671)
National Institute of Nursing Research (T32NR007066)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR064081)
Topics: Social Sciences › Decision Sciences › Management Science and Operations Research › Psychometric Methodologies and Testing
Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
Keywords: minimally important difference, PROMIS, pain interference, patient-reported outcomes, anchor-based estimation, distribution-based estimation, chronic low back pain, osteoarthritis pain, stroke, Brief Pain Inventory, global rating of change
MeSH terms: Patient Reported Outcome Measures, Aged, Cross-Sectional Studies, Disability Evaluation, Female, Humans, Male, Middle Aged, Pain Measurement, Psychometrics, Randomized Controlled Trials as Topic, Treatment Outcome, Self Report, Chronic Pain

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Estimating minimally important differences for the PROMIS pain interference scales: results from 3 randomized clinical trials

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