Cited by 199Psychometric Methodologies and TestingMusculoskeletal pain and rehabilitationPain Management and Opioid Use

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Estimating minimally important differences for the PROMIS pain interference scales: results from 3 randomized clinical trials

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Chen, Chen X., Kroenke, Kurt, Stump, Timothy E., Kean, Jacob, Carpenter, Janet S., Krebs, Erin E., Bair, Matthew J., Damush, Teresa M., Monahan, Patrick O.·2018·Pain

DOI 10.1097/j.pain.0000000000001121PMC PMC5860950

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Abstract

Minimally important difference (MID) refers to the smallest meaningful difference that carries implications for patient care. Minimally important differences are necessary to help interpret patient-reported pain outcomes in research and clinical practice. The PROMIS pain interference scales were validated across diverse samples; however, more information about their MIDs could improve their interpretability. The purpose of this study was to estimate MIDs for 4 fixed-length PROMIS pain interference scales, including the 6-item Pain Short Form and the 4-, 6-, and 8-item pain interference scales used in the PROMIS profile instruments. Data were analyzed from 3 randomized controlled trials (N = 759). The 3 samples, respectively, consisted of patients with chronic low back pain (n = 261), chronic back pain or hip/knee osteoarthritis pain (n = 240), and a history of stroke (n = 258). For each sample, anchor- and distribution-based approaches were used to estimate MIDs. Standard error of measurement and effect sizes were used as distribution-based MID estimates. Anchor-based MID estimates were established by mapping PROMIS pain interference scores onto established anchor measures, including the Brief Pain Inventory, and retrospective and prospective global ratings of change. The distribution- and anchor-based MID estimates showed convergence. For the pain samples, MID estimates ranged from 2 to 3 T-score points. For the nonpain sample, MID estimates ranged from 3.5 to 4.5 T-score points. The MID estimates were comparable across the 4 fixed-length scales. These MIDs can be used to evaluate treatment effects in research and clinical care and to calculate estimates for powering clinical trials.

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Authors: Chen, C. X., Kroenke, K., Stump, T. E., Kean, J., Carpenter, J. S., Krebs, E. E., Bair, M. J., Damush, T. M., & Monahan, P. O.
Affiliations: Indiana University Indianapolis (US)
Regenstrief Institute (US)
University of Utah (US)
University of Minnesota (US)
Corresponding author: Chen, Chen X.
ORCID: Chen, Chen X.
Kroenke, Kurt
Stump, Timothy E.
Kean, Jacob
Carpenter, Janet S.
Krebs, Erin E.
Bair, Matthew J.
Damush, Teresa M.
Monahan, Patrick O.
Venue: Pain
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2017-12-01
Volume: 159
Issue: 4
Pages: 775-782
ISSN: 0304-3959 (ISSN-L)
1872-6623
DOI: 10.1097/j.pain.0000000000001121
PMC: PMC5860950
OpenAlex: W2773505783
Cited by: 199
References: 28
Citations by year: 2026: 21 · 2025: 22 · 2024: 12 · 2023: 32 · 2022: 42 · 2021: 21 · 2020: 27 · 2019: 13 · 2018: 9
FWCI: 11.84
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Pain (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
IUScholarWorks (Indiana University) (submittedVersion)
Purdue University Indianapolis (Indiana University) (submittedVersion)
Funders: U.S. Department of Veterans Affairs (I01 HX000587, I01 HX000495, IK2 RX000879, I01 HX000671)
National Institute of Nursing Research (T32NR007066)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR064081)
Topics: Social Sciences › Decision Sciences › Management Science and Operations Research › Psychometric Methodologies and Testing
Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
Keywords: minimally important difference, PROMIS, pain interference, patient-reported outcomes, anchor-based estimation, distribution-based estimation, chronic low back pain, osteoarthritis pain, stroke, Brief Pain Inventory, global rating of change
MeSH terms: Patient Reported Outcome Measures, Aged, Cross-Sectional Studies, Disability Evaluation, Female, Humans, Male, Middle Aged, Pain Measurement, Psychometrics, Randomized Controlled Trials as Topic, Treatment Outcome, Self Report, Chronic Pain

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Estimating minimally important differences for the PROMIS pain interference scales: results from 3 randomized clinical trials

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