The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
The revised International Association for the Study of Pain definition of pain: concepts, challenges, and compromises
Open accessAbstract
The current International Association for the Study of Pain (IASP) definition of pain as “An unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage” was recommended by the Subcommittee on Taxonomy and adopted by the IASP Council in 1979. This definition has become accepted widely by health care professionals and researchers in the pain field and adopted by several professional, governmental, and nongovernmental organizations, including the World Health Organization. In recent years, some in the field have reasoned that advances in our understanding of pain warrant a reevaluation of the definition and have proposed modifications. Therefore, in 2018, the IASP formed a 14-member, multinational Presidential Task Force comprising individuals with broad expertise in clinical and basic science related to pain, to evaluate the current definition and accompanying note and recommend whether they should be retained or changed. This review provides a synopsis of the critical concepts, the analysis of comments from the IASP membership and public, and the committee's final recommendations for revisions to the definition and notes, which were discussed over a 2-year period. The task force ultimately recommended that the definition of pain be revised to “An unpleasant sensory and emotional experience associated with, or resembling that associated with, actual or potential tissue damage,” and that the accompanying notes be updated to a bulleted list that included the etymology. The revised definition and notes were unanimously accepted by the IASP Council early this year.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The International Association for the Study of Pain also establishes a relationship between fear-painknowledge, as they state that pain not only represents the sensation of physical harm, but also an emotional experience that can be influenced by other emotions, such as anxiety or fear of the unknown [53].”
From Prevention of non-specific back pain through exercise and education: A systematic review and meta-analysis (2024) · cites this paper as [53]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The qualitative content analysis process
Elo, S., & Kyngäs, H. (2008) · Journal of Advanced Nursing · doi:10.1111/j.1365-2648.2007.04569.x · Cited by 22,617 · cited 1×
“Responses to the open-ended questions were analyzed by using inductive content analysis.(16) We received 808 responses from individuals across 46 countries.”
MethodTreede, R.-D., Rief, W., Barke, A., Aziz, Q., Bennett, M. I., Benoliel, R., Cohen, M., Evers, S., Finnerup, N. B., First, M. B., et al. (2019) · Pain · doi:10.1097/j.pain.0000000000001384 · Cited by 3,478
Self-citationA classification of chronic pain for ICD-11
Treede, R.-D., Rief, W., Barke, A., Aziz, Q., Bennett, M. I., Benoliel, R., Cohen, M., Evers, S., Finnerup, N. B., First, M. B., et al. (2015) · Pain · doi:10.1097/j.pain.0000000000000160 · Cited by 2,822
Self-citation(1979) · PubMed · Cited by 1,355
A new definition of neuropathic pain
Jensen, T., Baron, R., Haanpää, M., Kalso, E., Loeser, J., Rice, A., & Treede, R. (2011) · Pain · doi:10.1016/j.pain.2011.06.017 · Cited by 1,343
The Kyoto protocol of IASP Basic Pain Terminology ☆
Loeser, J. D., & Treede, R. (2008) · Pain · doi:10.1016/j.pain.2008.04.025 · Cited by 1,240
Do we need a third mechanistic descriptor for chronic pain states?
Kosek, E., Cohen, M. L., Baron, R., Gebhart, G. F., Micó, J. A., Rice, A. S. C., Rief, W., & Sluka, K. A. (2016) · Pain · doi:10.1097/j.pain.0000000000000507 · Cited by 972
Self-citationBedson, J., & Croft, P. R. (2008) · BMC Musculoskeletal Disorders · doi:10.1186/1471-2474-9-116 · Cited by 951 · cited 2×
“An illustrative example is the discordance between reports of pain and the structural abnormalities visualized by imaging in patients with knee osteoarthritis.(6,30,36) The IASP has defined nociplastic pain as “pain that arises from altered nociception despite no clear evidence of actual or threatened tissue damage ca…”
BackgroundUpdating the definition of pain
Williams, A. C. D. C., & Craig, K. D. (2016) · Pain · doi:10.1097/j.pain.0000000000000613 · Cited by 754 · cited 3×
“experience of pain.(37) In addition, the term “unpleasant” has been debated as potentially trivializing the severe pain and suffering associated with many acute and chronic clinical pain states and fails to capture “the full range of words that could be used to describe the experience” and its associated suffering.”
BackgroundEditorial The need of a taxonomy
&NA;, &. (1979) · Pain · doi:10.1016/0304-3959(79)90046-0 · Cited by 413
Treede, R. (2018) · PAIN Reports · doi:10.1097/pr9.0000000000000643 · Cited by 372 · cited 1×
“Several proposed modifications to the current definition of pain have stimulated considerable discussion with strong, sometimes fervent, opinions favoring or opposing the need for revision.(1,4,5,11,12,15,29,31,32,39,40) Acknowledging these ongoing discussions, the IASP president, Judith Turner, formed a Presidential…”
Background(1996) · Pain · doi:10.1016/0304-3959(96)03135-1 · Cited by 343
Brain imaging tests for chronic pain: medical, legal and ethical issues and recommendations
Davis, K. D., Flor, H., Greely, H. T., Iannetti, G. D., Mackey, S., Ploner, M., Pustilnik, A. C., Tracey, I., Treede, R., & Wager, T. D. (2017) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.122 · Cited by 321 · cited 2×
“Davis et al.14 provide the consensus of an IASP task force that although brain imaging has thepotential to increase the understandingof the neuralmechanismsof pain and its treatment, it is not a replacement for the verbal report of pain in humans.”
BackgroundSelf-citationReconsidering the International Association for the Study of Pain definition of pain
Cohen, M. L., Quintner, J. L., & van Rysewyk, S. (2018) · PAIN Reports · doi:10.1097/pr9.0000000000000634 · Cited by 263 · cited 5×
“” Cohen et al.(10) offered the following revised definition: “Pain is a mutually recognizable somatic experience that reflects a person’s apprehension of threat to their bodily or existential integrity.”
BackgroundInfluentialSelf-citationQuantifying cerebral contributions to pain beyond nociception
Woo, C., Schmidt, L., Krishnan, A., Jepma, M., Roy, M., Lindquist, M. A., Atlas, L. Y., & Wager, T. D. (2017) · Nature Communications · doi:10.1038/ncomms14211 · Cited by 233 · cited 1×
“It was pointed out that although pain and nociception were clearly not the same, the additional phrase “the experience of pain cannot be deduced from activity in sensory pathways” may not be precise because recent studies suggest that a multivariate pattern signature in brain regions may predict pain above and beyond…”
BackgroundFields, H. L. (1999) · Pain · doi:10.1016/s0304-3959(99)00139-6 · Cited by 179
The IASP classification of chronic pain for ICD-11: functioning properties of chronic pain
Nugraha, B., Gutenbrunner, C., Barke, A., Karst, M., Schiller, J., Schäfer, P., Falter, S., Korwisi, B., Rief, W., Treede, R.-D., et al. (2019) · Pain · doi:10.1097/j.pain.0000000000001433 · Cited by 153
Logic, truth and language in concepts of pain
Merskey, H. (1994) · Quality of Life Research · doi:10.1007/bf00433379 · Cited by 127 · cited 1×
“”(23) Merskey, the chair of the IASP Subcommittee on Taxonomy, recognized that pain was “a psychological concept and not a physical measure” and that the experience of pain had to be distinguished from noxious stimulation.(25,26) Thus, the current (1979) IASP definition acknowledges that although tissue injury is a co…”
BackgroundDefending the IASP Definition of Pain
Aydede, M. (2017) · The Monist · doi:10.1093/monist/onx021 · Cited by 72 · cited 2×
“A detailed critique of its then-proposed definition of pain was submitted to the task force by Professor Murat Aydede, a regular contributor to the philosophy of pain-related psychology and cognitive science.(4,5) Some task forcemembers agreedwith Aydede that replacing “described in terms of” with the proposed languag…”
BackgroundMethodDoes the IASP definition of pain need updating?
Aydede, M. (2019) · PAIN Reports · doi:10.1097/pr9.0000000000000777 · Cited by 56
Imaging the painful osteoarthritic knee joint: what have we learned?
Wenham, C. Y. J., & Conaghan, P. G. (2009) · Nature Reviews Rheumatology · doi:10.1038/ncprheum1023 · Cited by 55 · cited 2×
“An illustrative example is the discordance between reports of pain and the structural abnormalities visualized by imaging in patients with knee osteoarthritis.(6,30,36) The IASP has defined nociplastic pain as “pain that arises from altered nociception despite no clear evidence of actual or threatened tissue damage ca…”
BackgroundFactors for Pain in Patients With Different Grades of Knee Osteoarthritis
Schiphof, D., Kerkhof, H. J. M., Damen, J., Klerk, B. M. B., Albert Hofman, D., Koes, B. W., van Meurs, J. B. J., & Bierma‐Zeinstra, S. (2012) · Arthritis Care & Research · doi:10.1002/acr.21886 · Cited by 54 · cited 2×
“An illustrative example is the discordance between reports of pain and the structural abnormalities visualized by imaging in patients with knee osteoarthritis.(6,30,36) The IASP has defined nociplastic pain as “pain that arises from altered nociception despite no clear evidence of actual or threatened tissue damage ca…”
BackgroundConsciousness, behavior, and clinical impact of the definition of pain
Anand, K. J. S., Rovnaghi, C. R., Walden, M., & Churchill, J. (1999) · Pain Forum · doi:10.1016/s1082-3174(99)70029-2 · Cited by 49 · cited 1×
“Criticisms of the IASP definition have included that it is “Cartesian,” ignoring the multiplicity of mind–body interactions,(27) and that it neglects “the ethical dimensions of pain” and does not adequately address pain in disempowered and neglected populations, such as neonates and the elderly.(3,13) It has been argu…”
BackgroundPerspectives on next steps in classification of oro‐facial pain – part 1: role of ontology
Ceusters, W. M., Michelotti, A., Raphael, K. G., Durham, J., & Ohrbach, R. K. (2015) · Journal of Oral Rehabilitation · doi:10.1111/joor.12336 · Cited by 34 · cited 1×
“Thus, a revised definition of pain is very timely and aligns with this and other current efforts to advance ontological frameworks within which pain resides.(9,34) These combined efforts of IASP are important steps for recognizing pain as an important health condition and will transform pain research and the care of p…”
BackgroundComment on Editorial by Anand and Craig
Derbyshire, S. W. G. (1996) · Pain · doi:10.1016/0304-3959(96)03170-3 · Cited by 21
New pain terminology: A work in progress
Jensen, T. S., & Gebhart, G. F. (2008) · Pain · doi:10.1016/j.pain.2008.10.014 · Cited by 20
Defining pain: past, present, and future
Alcock, M. (2017) · Pain · doi:10.1097/j.pain.0000000000000828 · Cited by 19 · cited 1×
“Several proposed modifications to the current definition of pain have stimulated considerable discussion with strong, sometimes fervent, opinions favoring or opposing the need for revision.(1,4,5,11,12,15,29,31,32,39,40) Acknowledging these ongoing discussions, the IASP president, Judith Turner, formed a Presidential…”
BackgroundA conceptual framework for “updating the definition of pain”
Tesarz, J., & Eich, W. (2017) · Pain · doi:10.1097/j.pain.0000000000000878 · Cited by 17 · cited 2×
“The goal was to develop a clear, concise, and unambiguous statement that describes the varied experiences of pain, while recognizing its diversity and complexity.(31) The task force acknowledged from its early deliberations that the note section would benefit from revision.”
BackgroundCritical comments on Williams and Craig's recent proposal for revising the definition of pain
Wright, A., & Aydede, M. (2017) · Pain · doi:10.1097/j.pain.0000000000000765 · Cited by 16 · cited 1×
“Several proposed modifications to the current definition of pain have stimulated considerable discussion with strong, sometimes fervent, opinions favoring or opposing the need for revision.(1,4,5,11,12,15,29,31,32,39,40) Acknowledging these ongoing discussions, the IASP president, Judith Turner, formed a Presidential…”
BackgroundA Criticism of the IASPs Definition of Pain
Wright, A. (2011) · Journal of Consciousness Studies · Cited by 16
Primary requirements for an ethical definition of pain
Cunningham, N. E. (1999) · Pain Forum · doi:10.1016/s1082-3174(99)70033-4 · Cited by 11
Cunningham, N. (1998) · Pain · doi:10.1016/s0304-3959(97)00091-2 · Cited by 6
Situating pain in a more helpful place
Osborn, M. (2018) · PAIN Reports · doi:10.1097/pr9.0000000000000642 · Cited by 4
Craig, K. D., & Williams, A. C. D. C. (2017) · Pain · doi:10.1097/j.pain.0000000000000766 · Cited by 2
Research works printed but not linked: 2
- Anand, 1996, New perspectives on the definition of pain, PAIN, 67, 3
- Cunningham, 1998, Comments on derbyshire, PAIN, 67 (1996) 210–11, PAIN, 74, 102
Cited by
Sorted by citations
Chronic pain: an update on burden, best practices, and new advances
Cohen, S. P., Vase, L., & Hooten, W. M. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00393-7 · Cited by 2,614
Neuropathic Pain: From Mechanisms to Treatment
Finnerup, N. B., Kuner, R., & Jensen, T. S. (2020) · Physiological Reviews · doi:10.1152/physrev.00045.2019 · Cited by 1,727
Self-citationKnezevic, N. N., Candido, K. D., Vlaeyen, J. W. S., Van Zundert, J., & Cohen, S. P. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00733-9 · Cited by 1,345
Management of Musculoskeletal Pain: An Update with Emphasis on Chronic Musculoskeletal Pain
El-Tallawy, S. N., Nalamasu, R., Salem, G. I., LeQuang, J. A., Pergolizzi, J. V., & Christo, P. J. (2021) · Pain and Therapy · doi:10.1007/s40122-021-00235-2 · Cited by 622
GLP-1 Receptor Agonists: Beyond Their Pancreatic Effects
Zhao, X., Wang, M., Wen, Z., Lu, Z., Cui, L., Fu, C., Xue, H., Liu, Y., & Zhang, Y. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.721135 · Cited by 463
Metadata
- Authors
- Raja, S. N., Carr, D. B., Cohen, M., Finnerup, N. B., Flor, H., Gibson, S., Keefe, F. J., Mogil, J. S., Ringkamp, M., Sluka, K. A., Song, X.-J., Stevens, B., Sullivan, M. D., Tutelman, P. R., Ushida, T., & Vader, K.
- Affiliations
- Johns Hopkins University (US)
- Tufts University (US)
- UNSW Sydney (AU)
- Aarhus University (DK)
- Heidelberg University (DE)
- The University of Melbourne (AU)
- Duke University (US)
- McGill University (CA)
- University of Iowa (US)
- Southern University of Science and Technology (CN)
- University of Toronto (CA)
- University of Washington (US)
- Dalhousie University (CA)
- Aichi Medical University (JP)
- Queen's University (CA)
- Corresponding author
- Raja, Srinivasa N.
- ORCID
- Venue
- Pain
- Published
- 2020-09
- Volume
- 161
- Issue
- 9
- Pages
- 1976-1982
- ISSN
- 0304-3959 (ISSN-L)
- 1872-6623
- PMC
- PMC7680716
- OpenAlex
- W3043476716
- Cited by
- 5,223
- References
- 34
- Citations by year
- 2026: 930 · 2025: 1042 · 2024: 1021 · 2023: 905 · 2022: 757 · 2021: 484 · 2020: 78
- FWCI
- 70.88
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- other-oa
- Locations
- Pain (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (P30AG064201, R01AG058702)
- National Cancer Institute (UG1CA189824)
- National Institute of Nursing Research (U2CNR014637, U24NR014637)
- National Institute of Neurological Disorders and Stroke (R01NS097221, R01NS026363, U24NS112873)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR073187, R01AR070875, UG3AR076387)
- National Center for Complementary and Integrative Health (U24AT010961, U24AT009676)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Social Sciences › Arts and Humanities › History and Philosophy of Science › Medicine, History, and Philosophy
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- pain definition, International Association for the Study of Pain, pain classification, concept of pain, tissue damage
- MeSH terms
- Humans, Pain
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review