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Cited by 6Schizophrenia research and treatmentBone health and osteoporosis researchBone Metabolism and Diseases

The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.

Acute Effects of Haloperidol, Amisulpride, and Quetiapine on Bone Turnover Markers in Patients With Schizophrenia

Liang, Ying, Su, Yun-Ai, Zhao, Zhen-Guo, Gao, Nan, Huang, Ji-Zhong, Tang, Mao-Qin, Li, Ke-Qing, Yang, Fu-De, Yu, Xin, Si, Tian-Mei·2015·Journal of Clinical Psychopharmacology
DOI 10.1097/jcp.0000000000000379
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Abstract

OBJECTIVE: This prospective study sought to compare the acute effects of haloperidol, amisulpride, and quetiapine on serum markers of bone formation and resorption in relatively young patients with minimal previous exposure to antipsychotic drugs. METHODS: Patients included in the study were randomly assigned to receive haloperidol, amisulpride, or quetiapine monotherapy in an open-label manner. Serum osteocalcin (OC, a marker of bone formation), C-terminal peptide of type I collagen (CTX, a marker of bone resorption), prolactin (PRL), estradiol, and testosterone were measured in 70 patients at baseline and after 4 weeks of antipsychotic treatment. RESULTS: A repeated-measures analysis of variance revealed a significant difference in CTX levels and in the OC to CTX ratio between treatment groups (F = 4.481, P < 0.05; F = 8.114, P < 0.01). After 4 weeks of treatment, only the amisulpride group had significantly increased CTX levels and decreased OC/CTX. In addition, an obvious increase in PRL level and a reduction of sex hormone secretion after amisulpride treatment were found. No significant changes in bone turnover were observed in the haloperidol or quetiapine groups. Notably, a positive correlation between the CTX change to the change in PRL after treatment (r = 0.255, P < 0.05) was observed. CONCLUSIONS: The PRL-raising antipsychotic drug amisulpride influenced bone turnover balance very early in the course of treatment, which may require long-term monitoring of bone metabolism. Bone resorption marker changes induced by acute antipsychotic drug treatment are likely related to increased PRL levels.

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Crossref · 10.1097/jcp.0000000000000379

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Metadata

Authors
Liang, Y., Su, Y.-A., Zhao, Z.-G., Gao, N., Huang, J.-Z., Tang, M.-Q., Li, K.-Q., Yang, F.-D., Yu, X., & Si, T.-M.
Affiliations
  • Peking University (CN)
  • Shanghai Mental Health Center (CN)
Corresponding author
  • Liang, Ying
  • Su, Yun-Ai
  • Gao, Nan
  • Yu, Xin
ORCID
Venue
Journal of Clinical Psychopharmacology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2015-10
Volume
35
Issue
5
Pages
583-586
ISSN
0271-0749 (ISSN-L)
DOI
10.1097/jcp.0000000000000379
OpenAlex
W2415218865
Cited by
6
References
19
Citations by year
2024: 2 · 2019: 1 · 2018: 2 · 2016: 1
FWCI
0.82
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Clinical Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Keywords
haloperidol, amisulpride, quetiapine, schizophrenia, bone turnover markers, osteocalcin, C-terminal telopeptide of type I collagen, bone resorption, bone formation, prolactin, antipsychotic adverse effects, sex hormones, antipsychotic monotherapy
MeSH terms
Quetiapine Fumarate, Amisulpride, Adult, Bone Resorption, Female, Haloperidol, Humans, Male, Osteogenesis, Prospective Studies, Schizophrenia, Sulpiride, Antipsychotic Agents, Biomarkers, Bone Remodeling, Young Adult

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