The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Sertraline for the Treatment of Depression in Alzheimer Disease
Open accessAbstract
Objective Depression is common in Alzheimer disease (AD), and antidepressants are commonly used for its treatment, however, evidence for antidepressant efficacy in this population is lacking. The authors conducted a multicenter, randomized, placebo-controlled trial titled "Depression in Alzheimer's Disease-2" to assess the efficacy and tolerability of sertraline for depression in AD.Methods One hundred thirty-one participants from five U.S. medical centers with mild-to-moderate AD (Mini-Mental State Examination scores 10-26) and depression of AD were randomized to double-blinded treatment with sertraline (N = 67) or placebo (N = 64), with a target dosage of 100 mg daily. Efficacy was assessed using logistic regressions and mixed effects models in an intention-to-treat analysis with imputation of missing data. Principal outcome measures were modified Alzheimer's Disease Cooperative Study-Clinical Global Impression of Change (mADCS-CGIC), change in Cornell Scale for Depression in Dementia (CSDD) scores, and remission defined by both mADCS-CGIC score <or=2 and CSDD score <or=6.Results mADCS-CGIC ratings (odd ratio [OR = 1.01], 95% confidence interval [CI]: 0.52-1.97, p = 0.98), CSDD scores (median difference at 12 weeks 1.2, 95% CI: 1.65-4.05, p = 0.41), and remission at 12 weeks of follow-up (OR = 2.06, 95% CI: 0.84-5.04, p = 0.11) did not differ between sertraline (N = 67) and placebo (N = 64). Sertraline-treated patients experienced more adverse events, most notably gastrointestinal and respiratory, than placebo-treated patients.Conclusion Sertraline did not demonstrate efficacy for the treatment depression symptoms in patients with AD. In addition, its use was associated with an increased incidence of adverse events. Thus, selective serotonin reuptake inhibitors may be of limited value for treating depression in patients with AD.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“(b) antidepressant medication causes severe neurological side effects, which reflect antidepressants interfering with brain function, possibly via altering neurotransmitter systems [29-31]”
From Risk analysis of use of different classes of antidepressants on subsequent dementia: A nationwide cohort study in Taiwan (2017) · cites this paper as [30]
Experimental — accuracy not yet measuredIn the citing paper
“While this method of drug discovery has the attractive feature of studying drugs with generally well-characterized safety profiles, it is inherently limited especially in terms of interpreting null results (Rosenberg et al., 2010).”
From Neuropsychiatric symptoms in Alzheimer's disease: what might be associated brain circuits? (2015) · cites this paper as Rosenberg et al., 2010
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282
Intraclass correlations: Uses in assessing rater reliability.
Shrout, P. E., & Fleiss, J. L. (1979) · Psychological Bulletin · doi:10.1037/0033-2909.86.2.420 · Cited by 24,532
Multiple Imputation for Nonresponse in Surveys
Rubin, D. B. (1987) · Wiley Series in Probability and Statistics · doi:10.1002/9780470316696 · Cited by 20,701
Multiple imputation after 18+ years
Rubin, D. B. (1996) · Journal of the American Statistical Association · doi:10.1080/01621459.1996.10476908 · Cited by 4,072
Multiple Imputation After 18+ Years
Rubin, D. B. (1996) · Journal of the American Statistical Association · doi:10.2307/2291635 · Cited by 2,686
Cornell scale for depression in dementia
Alexopoulos, G. S., Abrams, R. C., Young, R. C., & Shamoian, C. A. (1988) · Biological Psychiatry · doi:10.1016/0006-3223(88)90038-8 · Cited by 2,678
Point and 5‐year period prevalence of neuropsychiatric symptoms in dementia: the Cache County Study
Steinberg, M., Shao, H., Zandi, P., Lyketsos, C. G., Welsh‐Bohmer, K. A., Norton, M. C., Breitner, J. C. S., Steffens, D. C., & Tschanz, J. T. (2008) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1858 · Cited by 780
Self-citationMultiple Imputation for Nonresponse in Surveys
Campion, W. M., & Rubin, D. B. (1989) · Journal of Marketing Research · doi:10.2307/3172772 · Cited by 775
Exercise Plus Behavioral Management in Patients With Alzheimer Disease
Teri, L. L., Gibbons, L. E., McCurry, S. M., Logsdon, R. G., Büchner, D. M., Barlow, W. E., Kukull, W. A., LaCroix, A. Z., McCormick, W. C., & Larson, E. B. (2003) · JAMA · doi:10.1001/jama.290.15.2015 · Cited by 765
Schneider, L., Olin, J. T., Doody, R. S., Clark, C. M., Morris, J. C., Reisberg, ., Schmitt, F. A., Grundman, M., Thomas, R. G., & Ferris, S. H. (1997) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199700112-00004 · Cited by 646
Self-citation
Research works printed but not linked: 1
- Garre-Olmo, 2002, Carer's burden and depressive symptoms in patients with Alzheimer's disease. State after twelve months, Rev Neurol, 34, 601
Cited by
Sorted by citations
Items 201–250 of 250
Pai, R., Shashikala, I. M., & Sudhakar, P. H. (2024) · Journal of Psychiatry Spectrum · doi:10.4103/jopsys.jopsys_32_24 · Cited by 1
SSRI treatment in patients with depressive symptoms and Mild Cognitive Impairment
Giovanni, A. D., Paolo, E. D., & Cuzzoni, G. (2013) · Università degli Studi di Pavia · doi:10.6092/2039-1404.126.1604 · Cited by 1
Cognitive Dimensions of Depression: Assessment, Neurobiology, and Treatment
Jeon, S. W., & Kim, Y. (2017) · Springer eBooks · doi:10.1007/978-981-10-6577-4_11 · Cited by 1
Chick, C. F., Buck, C., & O'Hara, R. M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-800136-3.00009-0 · Cited by 1
Lee, A. T. C., Chiu, H. F. K., & Peisah, C. (2022) · International Psychogeriatrics · doi:10.1017/s1041610222000424 · Cited by 1
Dementia, depression and delirium in the very old : prevalences and associated factors
Mathillas, J. (2013) · KTH Publication Database DiVA (KTH Royal Institute of Technology) · Cited by 1
Ethical perspectives on relations between industry and neuropsychiatric medicine
Orfei, M. D., Caltagirone, C., & Spalletta, G. (2010) · International Review of Psychiatry · doi:10.3109/09540261.2010.484014 · Cited by 1
Antidepressant treatment of depression in dementia
Draper, B. (2012) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867412450475 · Cited by 1
Depression in Alzheimer's disease : biomarkers and treatment
Enache, D. (2015) · Figshare · Cited by 1
Schwertfeger, N., Regen, F., Szegedi, A., & Benkert, O. (2011) · Springer eBooks · doi:10.1007/978-3-642-19844-1_76
Evidence-based pharmacotherapy of Alzheimer's disease
Cotterell, D., & Brown, M. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9780511910395.014
Preserving the Memories: Managing Dementia
Seitz, D. P., Lee, P. E., Gill, S. S., & Rochon, P. A. (2010) · Wiley eBooks · doi:10.1002/9781118281796.ch7
Using Psychotropic Medications to Manage Problem Behaviors in Dementia
Wang, L. Y., & Raskind, M. A. (2013) · Wiley eBooks · doi:10.1002/9781118656082.ch8 · Cited by 1
Guimarães, H. C. (2012) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.5.2012.tde-24042012-170109
Cheng, H. Y. (2014) · Journal of Geriatrics and Palliative Care · doi:10.13188/2373-1133.1000001
Wood, J. K., & Weiner, M. (2013) · Neurodegenerative Disease Management · doi:10.2217/nmt.12.82
Suizidgefährdung bei Demenzkranken
Supprian, T. (2013) · NeuroTransmitter · doi:10.1007/s15016-013-0103-5
Psychopharmacologic Treatments for Alzheimer Disease and Related Dementias
Gomoll, B. P., Sanders, B., & Caserta, M. (2014) · Psychopharm Review · doi:10.1097/01.psyphr.0000442519.29442.6a · Cited by 1
Marano, C. M., Rosenberg, P. B., & Lyketsos, C. G. (2013) · Oxford University Press eBooks · doi:10.1093/med/9780199796816.003.0011
Self-citationModeling and simulation applications with potential impact in drug development and patient care
Li, C. H. (2014) · IUScholarWorks (Indiana University) · doi:10.7912/c2/1965
McCue, R. E., & Kelleher, M. (2017) · Wiley eBooks · doi:10.1002/9781119152606.ch12
Emprechtinger, J., & Rainer, M. K. (2019) · Springer eBooks · doi:10.1007/978-3-662-58130-8_15
Writers, A. M. (2019) · Drugs & Therapy Perspectives · doi:10.1007/s40267-019-00655-3
Pharmacological Agents to Treat Severe Neuropsychiatric Symptoms in Major Neurocognitive Disorders
Mischel, N., Rakesh, G., Gupta, S., Muzyk, A. J., & Masand, P. S. (2020) · Annals of Clinical Psychiatry · doi:10.1177/104012372003200212
Alzheimer’s disease and other neurocognitive disorders
Wang, L. Y., LaBardi, B. A., Raskind, M. A., & Peskind, E. R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-800136-3.00014-4
Psychotropic Drug Treatment in Later Life
Davies, S. (2020) · Cambridge University Press eBooks · doi:10.1017/9781911623465.020
Morsiani, A. (2011) · Cineforum
Current awareness in human psychopharmacology
(2010) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.1064
Lohse, M. J., & Müller-Oerlinghausen, B. (2013) · Springer eBooks · doi:10.1007/978-3-642-37124-0_39
Lohse, M. J., & Müller-Oerlinghausen, B. (2017) · Springer eBooks · doi:10.1007/978-3-662-54630-7_41
Current awareness in geriatric psychiatry
John Wiley & Sons, L. (2010) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2395
Lohse, M. J., & Müller-Oerlinghausen, B. (2014) · Springer eBooks · doi:10.1007/978-3-662-43487-1_39
Chapter 9. Depressive Disorders
Andrews, P., & Taylor, W. D. (2022) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615375196.ds09
Lenouvel, E., Tobias, S., Muehlbauer, V., Dallmeier, D., Denkinger, M. D., Klöppel, S., & Schönfeldt‐Lecuona, C. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4767641
Donix, M. (2024) · Springer eBooks · doi:10.1007/978-3-662-68297-5_6
Khundakar, A. A., & Thomas, A. J. (2015) · Advances in Alzheimer's disease · doi:10.3233/978-1-61499-542-5-187 · Cited by 1
Les symptômes dépressifs de la maladie d’Alzheimer : trouble affectif
Arbus, C., & Camus, V. (2011) · Les cahiers de l année gérontologique · doi:10.1007/s12612-011-0187-4
Joshi, A., Todd, S., Finn, D. P., McClean, P., & Wong‐Lin, K. (2022) · Figshare · doi:10.6084/m9.figshare.21298978
Joshi, A., Todd, S., Finn, D. P., McClean, P., & Wong‐Lin, K. (2022) · Figshare · doi:10.6084/m9.figshare.21298984
Park, S. H., Suh, J., & Roh, J. H. (2025) · Journal of Korean Medical Association · doi:10.5124/jkma.25.0141
Çetinkaya, A., Demirkol, M. E., & Avcı, A. O. (2026) · Konuralp Tıp Dergisi · doi:10.18521/ktd.1866798
Li, D., Yang, Y., Zhang, Y., Yue, J., Dong, B., & Ge, M. (2026) · Journal of Evidence-Based Medicine · doi:10.1111/jebm.70160
Clark, E. D., Perin, J., Devanand, D. P., Padala, P. R., Shade, D. M., Lyketsos, C. G., & Porsteinsson, A. P. (2026) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2026.08.011
Self-citation
Metadata
- Authors
- Rosenberg, P. B., Martin, B. K., Frangakis, C., Mintzer, J. E., Weintraub, D., Porsteinsson, A. P., Schneider, L. S., Rabins, P. V., Munro, C. A., Meinert, C. L., Lyketsos, C. G., & Drye, L. T.
- Affiliations
- Johns Hopkins University (US)
- Medical University of South Carolina (US)
- Mental Illness Research, Education and Clinical Centers (US)
- University of Rochester Medicine (US)
- University of Southern California (US)
- Corresponding author
- Rosenberg, Paul B.
- ORCID
- Venue
- The American Journal of Geriatric Psychiatry
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 18
- Issue
- 2
- Pages
- 136-145
- ISSN
- 1064-7481 (ISSN-L)
- PMC
- PMC2842121
- OpenAlex
- W1983522355
- Cited by
- 250
- References
- 36
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 14 · 2023: 5 · 2022: 14 · 2021: 8 · 2020: 9 · 2019: 14 · 2018: 13 · 2017: 14 · 2016: 11 · 2015: 21 · 2014: 21 · 2013: 24 · 2012: 24
- FWCI
- 19.46
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Geriatric Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5u01mh068014-05, 5u01mh066176-05, 5u01mh066174-05, 5u01mh066177-05, 5u01mh066175-05)
- National Institute on Aging (K08AG029157, P50AG005142, P50AG005146)
- National Institute of Mental Health (U01 MH068014, U01 MH066174, 1U01MH066175, 1U01MH068014, U01MH066177, 1U01MH066177, 1U01MH066176, U01 MH066175, 1U01MH066174, U01 MH066176, U01MH066136)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- sertraline, Alzheimer's disease, depression, selective serotonin reuptake inhibitors, antidepressant efficacy, adverse events, depression remission, Cornell Scale for Depression in Dementia, mild to moderate dementia
- MeSH terms
- Assessment of Medication Adherence, Aged, Alzheimer Disease, Depression, Double-Blind Method, Female, Humans, Male, Patient Dropouts, Placebos, Treatment Outcome, Drug Monitoring, Selective Serotonin Reuptake Inhibitors, Sertraline, Medication Adherence
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
