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Cited by 780Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsIntensive Care Unit Cognitive Disorders

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Point and 5‐year period prevalence of neuropsychiatric symptoms in dementia: the Cache County Study

Open access
Steinberg, Martin, Shao, Huibo, Zandi, Peter, Lyketsos, Constantine G., Welsh‐Bohmer, Kathleen A., Norton, Maria C., Breitner, John C.S., Steffens, David C., Tschanz, JoAnn T.·2008·International Journal of Geriatric Psychiatry
DOI 10.1002/gps.1858PMC PMC2932652
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Abstract

Background: Neuropsychiatric symptoms are nearly universal in dementia, yet little is known about their longitudinal course in the community. Objective: To estimate point and 5‐year period prevalence of neuropsychiatric symptoms in an incident sample of 408 dementia participants from the Cache County Study. Methods: The Neuropsychiatric Inventory assessed symptoms at baseline and at 1.5 years, 3.0 years, 4.1 years, and 5.3 years. Point prevalence, period prevalence and mean symptom severity at each time point were estimated. Results: Point prevalence for delusions was 18% at baseline and 34–38% during the last three visits; hallucinations, 10% at baseline and 19–24% subsequently; agitation/aggression fluctuated between 13% and 24%; depression 29% at baseline and 41–47% subsequently; apathy increased from 20% at baseline to 51% at 5.3 years; elation never rose above 1%; anxiety 14% at baseline and 24–32% subsequently; disinhibition fluctuated between 2% and 15%; irritability between 17% and 27%; aberrant motor behavior gradually increased from 7% at baseline to 29% at 5.3 years. Point prevalence for any symptom was 56% at baseline and 76–87% subsequently. Five‐year period prevalence was greatest for depression (77%), apathy (71%), and anxiety (62%); lowest for elation (6%), and disinhibition (31%). Ninety‐seven percent experienced at least one symptom. Symptom severity was consistently highest for apathy. Conclusions: Participants were most likely to develop depression, apathy, or anxiety, and least likely to develop elation or disinhibition. Give converging evidence that syndromal definitions may more accurately capture neuropsychiatric co‐morbidity in dementia, future efforts to validate such syndromes are warranted. Copyright © 2007 John Wiley & Sons, Ltd.

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Crossref · 10.1002/gps.1858

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2 of 2 references verified0 citation errors · 0 not checkable

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  • Agitation is common, persistent, difficult to treat, costly, and associated with severe adverse consequences for patients and caregivers.

    “Agitation is common, persistent, difficult to treat, costly, and associated with severe adverse consequences for patients and caregivers1–5.”

    From Effect of Citalopram on Agitation in Alzheimer Disease: The CitAD Randomized Clinical Trial (2014) · cites this paper as [2]

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Research works printed but not linked: 23

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Metadata

Authors
Steinberg, M., Shao, H., Zandi, P., Lyketsos, C. G., Welsh‐Bohmer, K. A., Norton, M. C., Breitner, J. C. S., Steffens, D. C., & Tschanz, J. T.
Affiliations
  • Johns Hopkins University (US)
  • Utah State University (US)
  • University of Washington (US)
  • Duke University (US)
Corresponding author
Steinberg, Martin
ORCID
Venue
International Journal of Geriatric Psychiatry
Publisher
Wiley
Published
2007-07-03
Volume
23
Issue
2
Pages
170-177
ISSN
  • 0885-6230 (ISSN-L)
  • 1099-1166
DOI
10.1002/gps.1858
PMC
PMC2932652
OpenAlex
W2139214514
Cited by
780
References
2
Citations by year
2026: 33 · 2025: 56 · 2024: 53 · 2023: 40 · 2022: 68 · 2021: 59 · 2020: 64 · 2019: 49 · 2018: 51 · 2017: 42 · 2016: 44 · 2015: 42 · 2014: 40 · 2013: 39 · 2012: 38
FWCI
5.30
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • International Journal of Geriatric Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Digital Commons - USU (Utah State University) (submittedVersion)
Funders
National Institute on Aging (R01AG011380, R01AG021136)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
Keywords
neuropsychiatric symptoms, dementia, prevalence, delusions, hallucinations, agitation, depression, apathy, anxiety, elation, disinhibition, irritability, aberrant motor behavior, symptom severity, longitudinal course
MeSH terms
Aged, Anxiety, Delusions, Dementia, Depression, Female, Hallucinations, Humans, Irritable Mood, Longitudinal Studies, Male, Mental Status Schedule, Psychomotor Agitation, Incidence, Prevalence

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