The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Increased Level of Serum Hepcidin in Female Adolescent Athletes
Abstract
Objective: To determine the serum hepcidin concentration and standard hematological parameters in a group of female adolescent athletes, compared with a group of nonathlete females. Design: A case–control study. Setting: A senior high school for athletes in Gothenburg, Sweden. Participants: All female athletes (70), at the school were offered to take part. Fifty-six athletes accepted. From a random sample of age-matched nonathletes, 71 students were recruited to the control group. Main Outcome Measures: Iron deficiency (ID) was determined by levels of serum iron, total iron-binding capacity, transferrin saturation (TS), and ferritin. Serum hepcidin was determined by a mass spectrometry method. All samples were taken at least 12 hours after training. Results: The main result was the finding of a significantly elevated serum hepcidin level in the athlete group, 4.7 nmol/L compared with 3.3 nmol/L (P < 0.001) in the nonathlete group. In the athlete group, the serum iron concentration was significantly lower, 14.0 μmol/L compared with 17.6 μmol/L (P = 0.003) in the nonathlete group. No difference was found regarding TS, total iron binding capacity, and ferritin. There was no difference in the occurrence of ID or iron deficiency anaemia (IDA). Conclusions: These findings show an increase in serum hepcidin in a large group of female athletes. The elevated hepcidin levels may affect the iron balance of the athletes, adding to the traditional explanation of dietary intake/iron loss balance.
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“In addition to insufficient intake, high-intensity sport can lead to ID through other mechanisms, such as increased iron demand, higher iron loss due to micro-trauma and ischemia of the gut, hemolysis, iron loss through increased sweating [12,18,25], and dysregulation of iron absorption and storage by elevated hepcidin levels post-exercise [26].”
From Iron Deficiency and Anemia in Male and Female Adolescent Athletes Who Engage in Ball Games (2023) · cites this paper as [12]
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Cites
Hepcidin—a regulator of intestinal iron absorption and iron recycling by macrophages
GANZ, T. (2005) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2004.08.020 · Cited by 393 · cited 2×
“The effect of exercise on hepcidin influence the iron balance and makes it difficult to interpret the degree of contribution by each possible determinant of ID because hepcidin is the main regulator of iron absorption in the gut and of release from the macrophages.(3) We have previously used serum ferritin ,16 mg/L as…”
BackgroundMethod
Research works printed but not linked: 10
- Sandstrom, 2012, Iron deficiency in adolescent female athletes—is iron status affected by regular sporting activity?, Clin J Sport Med., 22, 495, 10.1097/JSM.0b013e3182639522 · DOI · Paper page
- Hurrell, 2010, Iron bioavailability and dietary reference values, Am J Clin Nutr., 91, 1461S, 10.3945/ajcn.2010.28674F · DOI · Paper page
- Peeling, 2014, Iron status and the acute post-exercise hepcidin response in athletes, PLoS One, 9, e93002, 10.1371/journal.pone.0093002 · DOI · Paper page
- Hallberg, 1993, Prevalence of iron deficiency in Swedish adolescents, Pediatr Res., 34, 680, 10.1203/00006450-199311000-00023 · DOI · Paper page
- Dahlfors, 2015, Validation of a competitive ELISA assay for the quantification of human serum hepcidin, Scand J Clin Lab Invest., 75, 652
- Roecker, 2005, Iron-regulatory protein hepcidin is increased in female athletes after a marathon, Eur J Appl Physiol., 95, 569, 10.1007/s00421-005-0055-y · DOI
- Ziemann, 2013, Do high blood hepcidin concentrations contribute to low ferritin levels in young tennis players at the end of tournament season?, J Sports Sci Med., 12, 249
- Sim, 2014, A seven day running training period increases basal urinary hepcidin levels as compared to cycling, J Int Soc Sports Nutr., 11, 14, 10.1186/1550-2783-11-14 · DOI
- Fallon, 2001, The acute phase response and exercise: court and field sports, Br J Sports Med., 35, 170, 10.1136/bjsm.35.3.170 · DOI · Paper page
- McClung, 2013, Effects of a 7-day military training exercise on inflammatory biomarkers, serum hepcidin, and iron status, Nutr J., 12, 141, 10.1186/1475-2891-12-141 · DOI
Cited by
Iron Deficiency and Anemia in Male and Female Adolescent Athletes Who Engage in Ball Games
Nicotra, D., Arieli, R., Redlich, N., Navot-Mintzer, D., & Constantini, N. W. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12030970 · Cited by 26
Metadata
- Authors
- Sandström, G., Rödjer, S., Jacobsson, S., Nelson, D., & Börjesson, M.
- Affiliations
- Department of Anesthesiology and Intensive Care, Institute of Clinical Sciences, Sahlgrenska University Hospital, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden;
- Department of Hematology, Sahlgrenska University Hospital, Gothenburg, Sweden;
- Department of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden;
- Clinical Chemistry, University and Regional Laboratories, Helsingborg, Sweden; and
- Institute of Neuroscience and Physiology, Institution of Food, Nutrition and Sport Science and Sahlgrenska University Hospital, Östra, Gothenburg, Sweden.
- Venue
- Clinical Journal of Sport Medicine
- Published
- 2018-03
- Volume
- 28
- Issue
- 2
- Pages
- 180-183
- ISSN
- 1050-642X
- Cited by
- 5
- References
- 1
- Language
- en
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