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Cited by 117Mechanical Circulatory Support DevicesCardiac Arrest and ResuscitationCongenital Heart Disease Studies

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Pediatric Outcomes After Extracorporeal Membrane Oxygenation for Cardiac Disease and for Cardiac Arrest: A Review

Joffe, Ari R., Lequier, Laurance, Robertson, Charlene M.T.·2012·ASAIO Journal
DOI 10.1097/mat.0b013e31825a21ff
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Abstract

We reviewed reported survival and neurological outcomes, and predictors of these outcomes for pediatric cardiac extracorporeal membrane oxygenation (ECMO) and extracorporeal cardiopulmonary resuscitation (ECPR). We searched PubMed from 2000 to April 2011. Cumulative survival after cardiac ECMO in children was 788/1755 (45%); renal dysfunction, dialysis, neurologic complication, lactate, and ECMO duration consistently predicted this outcome, whereas single ventricle and ECPR did not. Neurological outcomes after cardiac ECMO were based on poorly described telephone questions in two studies for 47 patients with 51% significantly impaired and detailed follow-up testing for 42 patients in three studies with mental delay in 38% and mental score >85 (average or above) in 33%. Cumulative survival after ECPR in children was 371/762 (49%); noncardiac disease, renal dysfunction, neurologic complication, and pH on extracorporeal life support consistently predicted this outcome, whereas duration of CPR did not. Neurological outcomes after ECPR were based predominantly on the pediatric cerebral performance category (PCPC) score by chart review, with 161/181 (79%) having PCPC <2. No study reported detailed follow-up testing for survivors of ECPR. Survival outcomes of most cardiac subgroups were similar, except for concerning mortality in cavopulmonary connection patients. Priority areas for study include identification of potentially modifiable predictors of long-term outcomes.

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  • Progressive low cardiac output syndrome is the cause for 36% of post-operative extracorporeal life support cannulations, making it one of the most common indications for extracorporeal life support in the post-operative period.

    “Progressive LCOS is the cause for 36% of post-operative ECLS cannulations, making it one of the most common indications for ECLS in the post-operative period [28-32].”

    From Management of the Low Cardiac Output Syndrome Following Surgery for Congenital Heart Disease (2016) · cites this paper as [29]

  • Survival of pediatric patients who receive extracorporeal life support after cardiac surgery is approximately 41-49%.

    “Survival of pediatric patients who receive ECLS after cardiac surgery is approximately 41-49% [28-32].”

    From Management of the Low Cardiac Output Syndrome Following Surgery for Congenital Heart Disease (2016) · cites this paper as [29]

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Metadata

Authors
Joffe, A. R., Lequier, L., & Robertson, C. M. T.
Affiliations
University of Alberta (CA)
Corresponding author
  • Joffe, Ari R.
  • Lequier, Laurance
ORCID
Venue
ASAIO Journal
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2012-07
Volume
58
Issue
4
Pages
297-310
ISSN
1058-2916 (ISSN-L)
DOI
10.1097/mat.0b013e31825a21ff
OpenAlex
W2314154763
Cited by
117
References
0
Citations by year
2026: 3 · 2025: 7 · 2024: 6 · 2023: 5 · 2022: 13 · 2021: 8 · 2020: 8 · 2019: 9 · 2018: 12 · 2017: 8 · 2016: 6 · 2015: 11 · 2014: 10 · 2013: 10 · 2012: 1
FWCI
0.89
Type
journal article
Language
en
Open access
closed
Locations
  • ASAIO Journal (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Mechanical Circulatory Support Devices
  • Health Sciences › Medicine › Emergency Medicine › Cardiac Arrest and Resuscitation
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Congenital Heart Disease Studies
Keywords
extracorporeal membrane oxygenation, extracorporeal cardiopulmonary resuscitation, pediatric cardiac arrest, pediatric heart disease, survival outcomes, neurological outcome, cerebral performance category, prognostic factors, renal dysfunction, neurological complications, cavopulmonary connection, single ventricle, extracorporeal life support
MeSH terms
Adolescent, Cardiology, Child, Child, Preschool, Heart Arrest, Heart Diseases, Humans, Hydrogen-Ion Concentration, Infant, Infant, Newborn, Pediatrics, Extracorporeal Membrane Oxygenation, Cardiopulmonary Resuscitation, Treatment Outcome

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