The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Systemic immune-inflammation index predicts the severity of coronary stenosis in patients with coronary heart disease.
Abstract
Background: Coronary atherosclerosis is a systemic chronic inflammatory disease with variable occurrence and progression. Some laboratory parameters, such as the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and C-reactive protein (CRP) level, are used to evaluate the degree of inflammation and the severity of coronary artery disease (CAD). The neutrophil*platelet/lymphocyte is a novel systemic immune-inflammation index (SII), and its relationship with the development and severity of CAD is unclear. Objective: To investigate the association between the SII and the severity of CAD. Methods: Three-hundred and ninety-five patients who underwent coronary angiography were enrolled; among whom, 285 patients were included in the CAD group and 110 patients were included in the non-CAD group according to the WHO guidelines. Patients with CAD were further divided according to the Gensini score into the severe coronary stenosis group and the mild coronary stenosis group. The SII was calculated using the following formula: neutrophil*platelet/lymphocyte. Results: When the cutoff value of the SII was set at 439.44, the predictive power of CAD was the highest, with a sensitivity and specificity of 64.6 and 68.2%, respectively. When the cutoff value of the SII was set at 652.83, the predictive power of severe coronary stenosis was the highest, with a sensitivity and specificity of 71.0 and 86.0%, respectively. The area under the curve of the SII in predicting severe coronary stenosis was greater than that of the NLR, PLR and CRP level. Conclusion: The SII is an independent risk factor for the occurrence and severity of CAD.
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“in many inflammatory diseases, including cancers, coronary heart disease, and coronavirus disease 2019 (COVID-19), they are considered independent predictors (24, 35–37).”
From Investigation of systemic immune-inflammation index, neutrophil/high-density lipoprotein ratio, lymphocyte/high-density lipoprotein ratio, and monocyte/high-density lipoprotein ratio as indicators of inflammation in patients with schizophrenia and bipolar disorder (2022) · cites this paper as [36]
In the citing paper
“It can better reflect the body’s immune and inflammatory states than any aforementioned markers in isolation.”
From Investigation of systemic immune-inflammation index, neutrophil/high-density lipoprotein ratio, lymphocyte/high-density lipoprotein ratio, and monocyte/high-density lipoprotein ratio as indicators of inflammation in patients with schizophrenia and bipolar disorder (2022) · cites this paper as [36]
In the citing paper
“Previous studies have found that the SII has an important role in predicting the prognosis of patients with some physical diseases, such as tumors, cerebral infarction, cardiovascular disease, and acute pancreatitis (18, 20, 21, 36).”
From Investigation of systemic immune-inflammation index, neutrophil/high-density lipoprotein ratio, lymphocyte/high-density lipoprotein ratio, and monocyte/high-density lipoprotein ratio as indicators of inflammation in patients with schizophrenia and bipolar disorder (2022) · cites this paper as [36]
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Dziedzic, E. A., Gąsior, J. S., Tuzimek, A., Paleczny, J., Junka, A., Dąbrowski, M., & Jankowski, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179553 · Cited by 345
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Murat, B., Murat, S., Özgeyik, M., & Bilgin, M. (2022) · European Journal of Clinical Investigation · doi:10.1111/eci.13872 · Cited by 158
Wei, Y., Wang, T., Li, G., Feng, J., Deng, L., Xu, H., Yin, L., Ma, J., Chen, D., & Chen, J. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.941728 · Cited by 99
Metadata
- Authors
- Liu, Y., Ye, T., Chen, L., Jin, T., Sheng, Y., Wu, G., & Zong, G.
- Affiliations
- Wuxi Clinical College of Anhui Medical University, Wuxi 214044, China
- Corresponding author
- Liu, Yehong
- Ye, Ting
- Venue
- Coronary Artery Disease
- Published
- 2021-03-16
- Volume
- 32
- Issue
- 8
- Pages
- 715-720
- ISSN
- 0954-6928 (ISSN-L)
- OpenAlex
- W3143380783
- Cited by
- 179
- References
- 17
- Citations by year
- 2026: 26 · 2025: 46 · 2024: 52 · 2023: 35 · 2022: 18 · 2021: 2
- FWCI
- 9.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Coronary Artery Disease (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Keywords
- systemic immune-inflammation index, coronary stenosis severity, coronary artery disease, systemic inflammation, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, C-reactive protein, Gensini score, risk prediction
- MeSH terms
- Aged, Coronary Disease, Female, Humans, Inflammation, Male, Middle Aged, Risk Factors, Severity of Illness Index, Coronary Stenosis
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