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Cited by 348Drug-Induced Hepatotoxicity and ProtectionPoisoning and overdose treatmentsLiver Disease and Transplantation

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Acetaminophen Hepatotoxicity and Acute Liver Failure

Chun, Linda J., Tong, Myron J., Busuttil, Ronald W., Hiatt, Jonathan R.·2009·Journal of Clinical Gastroenterology
DOI 10.1097/mcg.0b013e31818a3854
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Abstract

Acetaminophen-induced hepatotoxicity is a common consequence of acetaminophen overdose and may lead to acute liver failure (ALF). Currently acetaminophen is the most common cause of ALF in both United States and United Kingdom, with a trend to increasing incidence in the United States. N-acetylcysteine is the most effective drug to prevent progression to liver failure with acetaminophen hepatotoxicity. Liver transplantation is the only definitive therapy that will significantly increase the chances of survival for advanced ALF. This communication reviews current information regarding causes and management of acetaminophen-induced hepatotoxicity and ALF.

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Crossref · 10.1097/mcg.0b013e31818a3854

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  • Paracetamol is a major cause of drug-induced acute liver failure and has been extensively studied for its liver damage.

    “Paracetamol is considered as one of the major causes for drug-induced ALF, and has been extensively studied for its liver damage. 3,4”

    From Caralluma umbellata Haw. protects liver against paracetamol toxicity and inhibits CYP2E1 (2017) · cites this paper as [3]

  • Paracetamol is metabolized to the reactive toxic metabolite NAPQI, with generation of reactive oxygen species that augment oxidative stress.

    “The mechanism behind paracetamol toxicity is mainly due to the reduction of hepatocyte GSH and increased CYP2E1 activity where paracetamol is metabolized to an extremely reactive toxic metabolite N-acetyl-p-benzoquinone imine (NAPQI) along with generation of reactive oxygen species in augmenting oxidative stress. 3,5,6”

    From Caralluma umbellata Haw. protects liver against paracetamol toxicity and inhibits CYP2E1 (2017) · cites this paper as [3]

  • Paracetamol toxicity is mainly due to reduction of hepatocyte GSH and increased CYP2E1 activity.

    “The mechanism behind paracetamol toxicity is mainly due to the reduction of hepatocyte GSH and increased CYP2E1 activity where paracetamol is metabolized to an extremely reactive toxic metabolite N-acetyl-p-benzoquinone imine (NAPQI) along with generation of reactive oxygen species in augmenting oxidative stress. 3,5,6”

    From Caralluma umbellata Haw. protects liver against paracetamol toxicity and inhibits CYP2E1 (2017) · cites this paper as [3]

Citations

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Metadata

Authors
Chun, L. J., Tong, M. J., Busuttil, R. W., & Hiatt, J. R.
Affiliations
  • Albert Einstein College of Medicine (US)
  • University of California, Los Angeles (US)
  • Plastic Surgery Hospital (CN)
Corresponding author
Chun, Linda J.
ORCID
Venue
Journal of Clinical Gastroenterology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2009-04
Volume
43
Issue
4
Pages
342-349
ISSN
0192-0790 (ISSN-L)
DOI
10.1097/mcg.0b013e31818a3854
OpenAlex
W2067570070
Cited by
348
References
2
Citations by year
2026: 9 · 2025: 12 · 2024: 31 · 2023: 14 · 2022: 12 · 2021: 18 · 2020: 17 · 2019: 16 · 2018: 11 · 2017: 23 · 2016: 26 · 2015: 21 · 2014: 25 · 2013: 27 · 2012: 31
FWCI
3.45
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Clinical Gastroenterology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
  • Health Sciences › Medicine › Emergency Medicine › Poisoning and overdose treatments
  • Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
Keywords
paracetamol, hepatotoxicity, acute liver failure, acetaminophen overdose, N-acetylcysteine, liver transplantation, drug-induced liver injury, incidence trends
MeSH terms
Acetaminophen, Acetylcysteine, Adult, Female, United Kingdom, Humans, Male, United States, Liver Transplantation, Liver Failure, Acute, Drug Overdose, Drug-Related Side Effects and Adverse Reactions

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