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Cited by 119Oral microbiology and periodontitis researchPeriodontal Regeneration and TreatmentsOral and gingival health research

The DOI matches its Crossref record, with a small difference in title or year; 56 of the 56 references it cites were found in a registry or an index.

Association between interleukin-8 levels and chronic periodontal disease: A PRISMA-compliant systematic review and meta-analysis

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Finoti, Livia S, Nepomuceno, Rafael, Pigossi, Suzane C, Corbi, Sâmia CT, Secolin, Rodrigo, Scarel-Caminaga, Raquel M.·2017·Medicine
DOI 10.1097/md.0000000000006932PMC PMC5459707
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Abstract

BACKGROUND: Current publications present contradictory findings regarding interleukin-8 (IL-8) levels in patients with chronic periodontitis (CP). This systematic review compile evidences of the IL8 mRNA and protein levels in gingival tissue, saliva, and gingival crevicular fluid (GCF) investigated in patients with CP. Moreover, 2 meta-analyses were made focusing on the IL-8 levels in GCF and saliva of patients with or without CP. METHODS: Electronic searches of the PubMed, Web of Science, and Scopus databases were conducted for publications up to February 2016 that investigated the levels of IL-8 detected in individuals with CP compared with health individuals. A total of 31 publications were included in the systematic review. For meta-analyses, the strength of association was calculated by pooled odds ratios with 95% confidence intervals using RevMan 5.1 software. Heterogeneity was examined using Higgins I-squared, tau-squared, and χ tests. RESULTS: In biopsies of gingival tissue of CP patients, all studies found higher IL8 mRNA levels, and the majority of studies showed higher IL-8 protein levels in this tissue of individuals with moderate to severe CP. Four studies investigating the IL-8 levels in saliva showed inconclusive results. In spite of some studies seemed to indicate higher levels of IL-8 in GCF of CP patients, the meta-analysis results showed significantly lower IL-8 levels (pg/μL) in GCF of CP patients in comparison with periodontally healthy subjects. CONCLUSIONS: We concluded that IL8 gene expression and IL-8 protein levels were higher in gingival tissues of CP patients when compared to periodontally health individuals. Meta-analysis of studies that measured IL-8 (pg/uL) in GCF found lower levels in CP patients. There are conflicting evidences regarding IL-8 levels in saliva.

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Figure 1 Meta-analysis forest plots of IL-8 levels in the GCF of patients with and without chronic periodontitis. The forest plot is a graphical depiction of the individual results that contributed to meta-analyses. The study results contributing to the meta-analyses were dived into groups according to the unit of measure used in each study. (A) Picograms/μL unit; (B) picograms/site unit. GCF = gingival crevicular fluid, IL-8 = interleukin-8.
Figure 1 Meta-analysis forest plots of IL-8 levels in the GCF of patients with and without chronic periodontitis. The forest plot is a graphical depiction of the individual results that contributed to meta-analyses. The study results contributing to the meta-analyses were dived into groups according to the unit of measure used in each study. (A) Picograms/μL unit; (B) picograms/site unit. GCF = gingival crevicular fluid, IL-8 = interleukin-8.CC BY-ND · PubMed Central
Figure 2 Flowchart outlining the search and the results obtained at different stages of this study.
Figure 2 Flowchart outlining the search and the results obtained at different stages of this study.CC BY-ND · PubMed Central
Figure 3 Meta-analysis forest plots of IL-8 levels (picograms/μL) in the saliva of patients with and without chronic periodontitis. IL-8 = interleukin-8.
Figure 3 Meta-analysis forest plots of IL-8 levels (picograms/μL) in the saliva of patients with and without chronic periodontitis. IL-8 = interleukin-8.CC BY-ND · PubMed Central

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Metadata

Authors
Finoti, L. S., Nepomuceno, R., Pigossi, S. C., Corbi, S. C., Secolin, R., & Scarel-Caminaga, R. M.
Affiliations
  • Universidade Estadual Paulista (Unesp) (BR)
  • Universidade Estadual de Campinas (UNICAMP) (BR)
ORCID
Venue
Medicine
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2017-06
Volume
96
Issue
22
Pages
e6932
ISSN
0025-7974 (ISSN-L)
DOI
10.1097/md.0000000000006932
PMC
PMC5459707
OpenAlex
W2617814315
Cited by
119
References
56
Citations by year
2026: 7 · 2025: 12 · 2024: 16 · 2023: 17 · 2022: 15 · 2021: 22 · 2020: 16 · 2019: 9 · 2018: 5
FWCI
1.15
Type
journal article
Language
en
Open access
Licence
cc-by-nd
Locations
  • Medicine (publishedVersion, cc-by-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nd)
  • PubMed Central (publishedVersion, cc-by-nd)
  • PubMed (publishedVersion)
  • Americanae (AECID Library) (publishedVersion, other-oa)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
Topics
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Health Sciences › Dentistry › Periodontics › Periodontal Regeneration and Treatments
  • Health Sciences › Dentistry › Periodontics › Oral and gingival health research
Keywords
interleukin-8, chronic periodontitis, gingival crevicular fluid, saliva, gingiva, IL-8 mRNA expression, periodontal biomarkers
MeSH terms
Humans, Biomarkers, Interleukin-8, Chronic Periodontitis

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