Periodontitis: a polymicrobial disruption of host homeostasis

Darveau, Richard P.

doi:10.1038/nrmicro2337

Cited by 1,688Oral microbiology and periodontitis researchPeriodontal Regeneration and TreatmentsDental Research and COVID-19

Periodontitis: a polymicrobial disruption of host homeostasis

Darveau, Richard P.·2010·Nature Reviews Microbiology

DOI 10.1038/nrmicro2337

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Abstract

Periodontitis, or gum disease, affects millions of people each year. Although it is associated with a defined microbial composition found on the surface of the tooth and tooth root, the contribution of bacteria to disease progression is poorly understood. Commensal bacteria probably induce a protective response that prevents the host from developing disease. However, several bacterial species found in plaque (the 'red-complex' bacteria: Porphyromonas gingivalis, Tannerella forsythia and Treponema denticola) use various mechanisms to interfere with host defence mechanisms. Furthermore, disease may result from 'community-based' attack on the host. Here, I describe the interaction of the host immune system with the oral bacteria in healthy states and in diseased states.

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As a result of complex interactions between subgingival biofilms and the host immune response, gingivitis can further develop to periodontitis with concomitant loss of periodontal supportive tissues.
“As a result of complex interactions between subgingival biofilms and the host immune response, gingivitis can further develop to periodontitis with concomitant loss of periodontal supportive tissues (Figure 7B).239,278,279”
From The dental plaque biofilm matrix (2021) · cites this paper as [239]
Accumulation of subgingival biofilms initiates development of clinical signs of gingivitis.
“Accumulation of subgingival biofilms initiates development of clinical signs of gingivitis”
From The dental plaque biofilm matrix (2021) · cites this paper as [239]
The logical first step in every periodontal treatment is mechanical removal of subgingival biofilms and calculus deposits.
“The logical first step in every periodontal treatment is mechanical removal of subgingival biofilms and calculus deposits.239,280,281”
From The dental plaque biofilm matrix (2021) · cites this paper as [239]

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Gingival Epithelial Cell Transcriptional Responses to Commensal and Opportunistic Oral Microbial Species
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An Immune Response Directed to Proteinase and Adhesin Functional Epitopes Protects against Porphyromonas gingivalis-Induced Periodontal Bone Loss
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Interleukin-8 and Intercellular Adhesion Molecule 1 Regulation in Oral Epithelial Cells by Selected Periodontal Bacteria: Multiple Effects ofPorphyromonas gingivalisvia Antagonistic Mechanisms
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Differential Induction of Human Beta‐Defensin Expression by Periodontal Commensals and Pathogens in Periodontal Pocket Epithelial Cells
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Identification of a signalling molecule involved in bacterial intergeneric communication
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Host-Microbe Interaction in the Gastrointestinal Tract
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Antagonistic lipopolysaccharides block<i>E. coli</i>lipopolysaccharide function at human TLR4 via interaction with the human MD-2 lipopolysaccharide binding site: Antagonistic LPSs bind to hMD-2
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Quantitative assessment of inflammatory cytokine gene expression in chronic adult periodontitis
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Novel Microarray Design Strategy To Study Complex Bacterial Communities
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Toll-like receptor 4-dependent recognition of structurally different forms of chemically synthesized lipid As ofPorphyromonas gingivalis
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The origin and variation in number of leukocytes in the human saliva.
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Periodontitis: from microbial immune subversion to systemic inflammation
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Impact of the global burden of periodontal diseases on health, nutrition and wellbeing of mankind: a call for global action
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Beyond the red complex and into more complexity: the polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology
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Polydopamine Nanoparticles as Efficient Scavengers for Reactive Oxygen Species in Periodontal Disease
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Authors: Darveau, R. P.
Affiliations: University of Washington (US)
Corresponding author: Darveau, Richard P.
ORCID: Darveau, Richard P.
Venue: Nature Reviews Microbiology
Publisher: Springer Science and Business Media LLC
Published: 2010-06-01
Volume: 8
Issue: 7
Pages: 481-490
ISSN: 1740-1526 (ISSN-L)
1740-1534
DOI: 10.1038/nrmicro2337
OpenAlex: W1997072139
Cited by: 1,688
References: 156
Citations by year: 2026: 101 · 2025: 107 · 2024: 125 · 2023: 115 · 2022: 118 · 2021: 126 · 2020: 153 · 2019: 113 · 2018: 93 · 2017: 126 · 2016: 113 · 2015: 104 · 2014: 107 · 2013: 82 · 2012: 56
FWCI: 9.36
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Microbiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
Health Sciences › Dentistry › General Dentistry › Dental Research and COVID-19
Keywords: periodontitis, co-infection, host-pathogen interaction, oral microbiota, red complex bacteria, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, dental plaque, commensal bacteria, host immune response, periodontal disease pathogenesis
MeSH terms: Animals, Humans, Periodontitis, Periodontium, Porphyromonas gingivalis, Bacterial Physiological Phenomena, Biofilms, Treponema denticola

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Periodontitis: a polymicrobial disruption of host homeostasis

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