The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Cardiac Involvement in Churg-Strauss Syndrome: Impact of Endomyocarditis
Abstract
Cardiac disease is a major contributor to disease-related death in Churg-Strauss syndrome (CSS). We conducted the current study to determine the prevalence and clinical impact of cardiac involvement in CSS patients. We performed a multicenter, cross-sectional analysis of patients diagnosed with CSS. Cardiac workup included electrocardiography, echocardiography, cardiac magnetic resonance imaging (MRI), and endomyocardial biopsy.We analyzed 49 patients with CSS: 22 patients had clinical evidence of cardiac involvement. A negative antineutrophil cytoplasmic antibodies (ANCA) test and much higher eosinophil counts (9947 vs. 3657/microL, respectively, p < 0.001) distinguished patients with cardiac involvement from those without. Impaired left ventricular function (50%), mild to severe valvular insufficiencies (73%), and pericardial effusions (41%) were common findings in these patients. Endomyocarditis was found in 13 patients (59%) as detected by cardiac MRI, cardiac thrombus formation, and endomyocardial biopsy, and was associated with impaired cardiac function. After a mean follow-up of 47 months, most patients had regained or maintained good cardiac function. However, patients with endomyocarditis had a more severe outcome. Two patients died (61 and 99 mo after diagnosis, respectively), both due to severe cardiomyopathy and heart failure.Cardiac involvement is common in patients with CSS and is associated with the absence of ANCA and high eosinophil counts. Endomyocarditis may represent the most severe manifestation eventually causing fatal outcome. A structured clinical assessment incorporating cardiac imaging with echocardiography and MRI can identify impaired cardiac function and endomyocardial abnormalities.
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Cites
Nomenclature of Systemic Vasculitides
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Allergic granulomatosis, allergic angiitis, and periarteritis nodosa.
Churg, J., & Strauss, L. (1951) · PubMed · Cited by 1,696
Systemic Vasculitis with Asthma and Eosinophilia: A Clinical Approach to the Churg-Strauss Syndrome
LANHAM, J. G., ELKON, K. B., PUSEY, C. D., & HUGHES, G. R. (1984) · Medicine · doi:10.1097/00005792-198403000-00001 · Cited by 1,238
Churg-Strauss Syndrome Clinical Study and Long-Term Follow-Up of 96 Patients
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Antineutrophil Cytoplasmic Antibodies and the Churg–Strauss Syndrome
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Cited by
Groh, M., Pagnoux, C., Baldini, C., Bel, E., Bottero, P., Cottin, V., Dalhoff, K., Dunogué, B., Gross, W., Holle, J., et al. (2015) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2015.04.022 · Cited by 476
Moosig, F., Bremer, J. P., Hellmich, B., Holle, J. U., Holl-Ulrich, K., Laudien, M., Matthis, C., Metzler, C., Nölle, B., Richardt, G., et al. (2013) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2012-201531 · Cited by 279
Cheng, C.-Y., Baritussio, A., Giordani, A. S., Iliceto, S., Marcolongo, R., & Caforio, A. L. P. (2022) · Autoimmunity Reviews · doi:10.1016/j.autrev.2022.103037 · Cited by 56
Uccello, G., Bonacchi, G., Rossi, V. A., Montrasio, G., & Beltrami, M. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm13010150 · Cited by 33
Churg-Strauss Syndrome or Eosinophilic Granulomatosis with Polyangiitis
Izquierdo-Domínguez, A., Cordero Castillo, A., Alobid, I., & Mullol, J. (2015) · Sinusitis · doi:10.3390/sinusitis1010024 · Cited by 8
Metadata
- Authors
- Neumann, T., Manger, B., Schmid, M., Kroegel, C., Hansch, A., Kaiser, W. A., Reinhardt, D., Wolf, G., Hein, G., Mall, G., Schett, G., & Zwerina, J.
- Venue
- Medicine
- Published
- 2009-07
- Volume
- 88
- Issue
- 4
- Pages
- 236-243
- ISSN
- 0025-7974 (ISSN-L)
- OpenAlex
- W2064940997
- Cited by
- 262
- References
- 19
- FWCI
- 12.71
- Type
- journal article
- Language
- en
- Open access
- closed
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- Neumann, T., Manger, B., Schmid, M., Kroegel, C., Hansch, A., Kaiser, W. A., Reinhardt, D., Wolf, G., Hein, G., Mall, G., Schett, G., & Zwerina, J. (2009). Cardiac Involvement in Churg-Strauss Syndrome: Impact of Endomyocarditis. Medicine. https://doi.org/10.1097/md.0b013e3181af35a5
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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