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Impact of caffeine in hepatitis C virus infection: a systematic review and meta-analysis
Abstract
Background/objectives: Hepatitis C virus (HCV) infection is one of the most common causes of cirrhosis. Several studies have linked caffeine consumption to a lower degree of liver fibrosis and inflammation among patients with chronic HCV infection, but the results were inconsistent. This meta-analysis was carried out with the aim of assessing the impact of caffeine consumption among HCV-infected patients. Participants and methods: A literature search was performed using MEDLINE and EMBASE from inception to January 2016. Studies that reported relative risks, odd ratios, or hazard ratios comparing the risk of advanced liver fibrosis or the risk of moderate to severe liver inflammation among HCV-infected patients who consumed caffeine on a regular basis versus those who did not were included. Pooled odds ratios (OR) and 95% confidence interval (CI) were calculated using a random-effect, generic inverse-variance method. Results: Five studies were included in the fibrosis analysis. The pooled OR of advanced liver fibrosis in HCV-infected patients who consumed caffeine on a regular basis versus those who did not was 0.48 (95% CI, 0.30–0.76, I 2=52%). Three studies were included in the inflammation analysis. The pooled OR of moderate to severe histologic inflammation among HCV-infected patients who consumed caffeine on a regular basis versus those who did not was 0.61 (95% CI, 0.35–1.04, I 2=43%). Conclusion: Our study showed a decreased risk of advanced liver fibrosis and liver inflammation among HCV-infected patients who consumed caffeine on a regular basis. Whether consumption of caffeine plays a role in the management of HCV infection requires further investigations.
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“Similar protective data were found in a meta-analysis concerning fibrosis in patients infected with the hepatitis C virus.”
From Effects of Coffee on the Gastro-Intestinal Tract: A Narrative Review and Literature Update (2022) · cites this paper as [194]
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“In the five studies included, the pooled OR of advanced liver cirrhosis in HCV patients who consumed caffeine regularly compared to an absence of consumption reached 0.48 (95% CI = 0.30–0.76), and the pooled OR for moderate/severe histological inflammation reached 0.61 (95% CI = 0.35–1.04) [194].”
From Effects of Coffee on the Gastro-Intestinal Tract: A Narrative Review and Literature Update (2022) · cites this paper as [194]
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“In the five studies included, the pooled OR of advanced liver cirrhosis in HCV patients who consumed caffeine regularly compared to an absence of consumption reached 0.48 (95% CI = 0.30–0.76), and the pooled OR for moderate/severe histological inflammation reached 0.61 (95% CI = 0.35–1.04) [194].”
From Effects of Coffee on the Gastro-Intestinal Tract: A Narrative Review and Literature Update (2022) · cites this paper as [194]
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Herzog, R., Álvarez-Pasquin, M. J., Díaz, C., Del Barrio, J. L., Estrada, J. M., & Gil, Á. (2013) · BMC Public Health · doi:10.1186/1471-2458-13-154 · Cited by 1,652
Caffeine as an Antioxidant: Inhibition of Lipid Peroxidation Induced by Reactive Oxygen Species
Devasagayam, T. P. A., Kamat, J. P., Mohan, H., & Kesavan, P. C. (1996) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(96)00040-5 · Cited by 331
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Cited by
Effects of Coffee on the Gastro-Intestinal Tract: A Narrative Review and Literature Update
Nehlig, A. (2022) · Nutrients · doi:10.3390/nu14020399 · Cited by 158
Kennedy, O. J., Fallowfield, J. A., Poole, R., Hayes, P. C., Parkes, J., & Roderick, P. J. (2021) · BMC Public Health · doi:10.1186/s12889-021-10991-7 · Cited by 58
Metadata
- Authors
- Wijarnpreecha, K., Thongprayoon, C., & Ungprasert, P.
- Affiliations
- Department of Internal Medicine, Bassett Medical Center, Cooperstown, New York
- Department of Internal Medicine, Division of Rheumatology, Mayo Clinic, Rochester, Minnesota, USA
- Venue
- European Journal of Gastroenterology & Hepatology
- Published
- 2017-01
- Volume
- 29
- Issue
- 1
- Pages
- 17-22
- ISSN
- 0954-691X
- Cited by
- 14
- References
- 2
- Language
- en
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