Mechanisms underlying pleiotropic effects of statins.
Abstract
Statins are the most efficacious hypolipidemic drugs available. Numerous meta-analyses of clinical trials have provided unequivocal evidence that statins are effective and safe in preventing cardiovascular morbidity and mortality in patients with and without pre-existing ischemic heart disease. With widespread usage of statins, its actions other than that of lipid-lowering have started to emerge. Although the effects of statins were initially attributed to a reduction in lipid levels, many benefits are now considered to stem from effects other than lipid modulation. In this review, we describe the mechanisms of these pleiotropic effects and the pathways involved in these effects.
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Statins have anti-inflammatory and immunomodulatory properties affecting both Th1 and Th2 immune responses.
“Multiple reports indicate that statins have anti-inflammatory and immunomodulatory properties affecting both Th1 and Th2 immune responses (Leung et al., 2003; McKay et al., 2004; Palaniswamy et al., 2010).”
From Atorvastatin Reduces the Survival of Candida albicans-Infected BALB/c Mice (2015) · cites this paper as Palaniswamy et al., 2010
Cites
BABIOR, B. M. (1999) · Blood · doi:10.1182/blood.v93.5.1464 · Cited by 2,147 · see citing works
Upregulation of Endothelial Nitric Oxide Synthase by HMG CoA Reductase Inhibitors
Laufs, U., Fata, V. L., Plutzky, J., & Liao, J. K. (1998) · Circulation · doi:10.1161/01.cir.97.12.1129 · Cited by 1,837 · see citing works
Weitz‐Schmidt, G., Welzenbach, K., Brinkmann, V., Kamata, T., Kallen, J. A., Bruns, C., Cottens, S., Takada, Y., & Hommel, U. (2001) · Nature Medicine · doi:10.1038/89058 · Cited by 1,041 · see citing works
Crisby, M., Fredrikson, G. N., Shah, P. K., Yano, J., Zhu, J., & Nilsson, J. Å. (2001) · Circulation · doi:10.1161/01.cir.103.7.926 · Cited by 999 · see citing works
Cellular Antioxidant Effects of Atorvastatin In Vitro and In Vivo
Waßmann, S., Laufs, U., Müller, K., Konkol, C., Ahlbory, K., Bäumer, A. T., Linz, W., Böhm, M., & Nickenig, G. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq0202.104081 · Cited by 589 · see citing works
HMG-CoA Reductase Inhibitors Reduce MMP-9 Secretion by Macrophages
Bellosta, S., Via, D. P., Canavesi, M., Pfister, P., Fumagalli, R., Paoletti, R., & Bernini, F. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.11.1671 · Cited by 512 · see citing works
Féron, O., Dessy, C., Desager, J., & Balligand, J. (2001) · Circulation · doi:10.1161/01.cir.103.1.113 · Cited by 418 · see citing works
Weber, C., Erl, W., Weber, K. S. C., & Weber, P. C. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00324-0 · Cited by 409 · see citing works
Inhibition of proinflammatory cytokine production by pravastatin
Rosenson, R. S., Tangney, C., & Casey, L. C. (1999) · The Lancet · doi:10.1016/s0140-6736(98)05917-0 · Cited by 376 · see citing works
Aviram, M., Rosenblat, M., Bisgaier, C. L., & Newton, R. S. (1998) · Atherosclerosis · doi:10.1016/s0021-9150(98)00032-x · Cited by 296 · see citing works
Inhibition of Monocyte Chemotactic Protein-1 Synthesis by Statins
Romano, M., Diomede, L., Sironi, M., Massimiliano, L., Sottocorno, M., Polentarutti, N., Guglielmotti, A., Albani, D., Bruno, A., Fruscella, P., et al. (2000) · Laboratory Investigation · doi:10.1038/labinvest.3780115 · Cited by 296 · see citing works
Simvastatin attenuates vascular leak and inflammation in murine inflammatory lung injury
Jacobson, J. R., Barnard, J. W., Grigoryev, D. N., Ma, S., Tuder, R. M., & Garcia, J. G. N. (2005) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00354.2004 · Cited by 270 · see citing works
Simvastatin Induces Heme Oxygenase-1
Lee, T., Chang, C.-C., Zhu, Y., & Shyy, J. Y.-J. (2004) · Circulation · doi:10.1161/01.cir.0000140694.67251.9c · Cited by 266 · see citing works
Kallen, J. A., Welzenbach, K., Ramage, P., Geyl, D., Kriwacki, R. W., Legge, G. B., Cottens, S., Weitz‐Schmidt, G., & Hommel, U. (1999) · Journal of Molecular Biology · doi:10.1006/jmbi.1999.3047 · Cited by 256 · see citing works
Bourcier, T., & Libby, P. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.2.556 · Cited by 233 · see citing works
ToddBourcier, & PeterLibby (2000) · Arteriosclerosis Thrombosis and Vascular Biology · Cited by 233 · see citing works
Kleemann, R., Verschuren, L., de Rooij, B. F., Lindeman, J. H. N., de Maat, M. P. M., Szalai, A. J., Princen, H. M. G., & Kooistra, T. (2004) · Blood · doi:10.1182/blood-2003-11-3791 · Cited by 180 · see citing works
The antioxidant defense protein heme oxygenase 1 is a novel target for statins in endothelial cells
Grosser, N., Hemmerle, A., Berndt, G., Erdmann, K., Hinkelmann, U., Schürger, S., Wijayanti, N., Immenschuh, S., & Schröder, H. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.09.009 · Cited by 161 · see citing works
Simvastatin Blunts Endotoxin-Induced Tissue Factor In Vivo
Steiner, S., Speidl, W. S., Pleiner, J., Seidinger, D., Zorn, G., Kaun, C., Wojta, J., Huber, K., Minar, E., Wolzt, M., et al. (2005) · Circulation · doi:10.1161/01.cir.0000158665.27783.0c · Cited by 145 · see citing works
Statins and the Acute-Phase Response
Munford, R. S. (2001) · New England Journal of Medicine · doi:10.1056/nejm200106283442609 · Cited by 143 · see citing works
Shi, J., Wang, J., Zheng, H., Ling, W., Joseph, J., Li, D., Mehta, J. L., Ponnappan, U., Lin, P., Fink, L. M., et al. (2003) · Blood Coagulation & Fibrinolysis · doi:10.1097/00001721-200309000-00010 · Cited by 121 · see citing works
HMG-CoA Reductase Inhibitors Inhibit Inducible Nitric Oxide Synthase Gene Expression in Macrophages
Huang, K., Chen, C., Chen, J.-C., & Lin, W. (2003) · Journal of Biomedical Science · doi:10.1007/bf02256431 · Cited by 96 · see citing works
SUPEROXIDE ANION OVERPRODUCTION IN SEPSIS: EFFECTS OF VITAMIN E AND SIMVASTATIN
Durant, R., Klouche, K., Delbosc, S., Morena, M., Amigues, L., Beraud, J. J., Canaud, B., & Cristol, J. P. (2004) · Shock · doi:10.1097/01.shk.0000129197.46212.7e · Cited by 75 · see citing works
Wang, H., Li, J., Huang, C.-X., & Jiang, H. (2004) · Clinica Chimica Acta · doi:10.1016/j.cccn.2004.10.007 · Cited by 57 · see citing works
HMG-CoA reductase inhibitors for lowering elevated levels of C-reactive protein
Chan, K. Y., Boucher, E. S., Gandhi, P. J., & Silva, M. A. (2004) · American Journal of Health-System Pharmacy · doi:10.1093/ajhp/61.16.1676 · Cited by 53 · see citing works
März, W., Winkler, K., Nauck, M., Böhm, B. O., & Winkelmann, B. R. (2003) · The American Journal of Cardiology · doi:10.1016/s0002-9149(03)00633-7 · Cited by 40 · see citing works
Lovastatin induces differentiation of Mono Mac 6 cells
Weber, C., Erl, W., & Weber, P. C. (1995) · Cell Biochemistry and Function · doi:10.1002/cbf.290130408 · Cited by 20 · see citing works
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Lipworth, L., Fazio, S., Kabagambe, E., Munro, H., Nwazue, V., Tarone, R., McLaughlin, J., Blot, W., & Sampson, U. (2013) · Clinical Epidemiology · doi:10.2147/clep.s53492 · Cited by 26 · see citing works
Atorvastatin Reduces the Survival of Candida albicans-Infected BALB/c Mice
Rahal, E. A., Constantin, W. N., Zeidan, N., & Abdelnoor, A. M. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.01474 · Cited by 14 · see citing works
- Authors
- Palaniswamy, C., Selvaraj, D. R., Selvaraj, T., & Sukhija, R.
- Affiliations
- New York Medical College (US)
- All India Institute of Medical Sciences (IN)
- Corresponding author
- Palaniswamy, Chandrasekar
- Venue
- American Journal of Therapeutics
- Published
- 2010-01
- Volume
- 17
- Issue
- 1
- Pages
- 75-78
- ISSN
- 1075-2765 (ISSN-L)
- OpenAlex
- W2085113732
- Cited by
- 35
- References
- 27
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 3 · 2021: 1 · 2019: 2 · 2017: 1 · 2016: 3 · 2015: 3 · 2014: 3 · 2013: 7 · 2012: 4
- FWCI
- 5.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- statins, pleiotropy, cardioprotection, ischemic heart disease, drug mechanisms of action
- MeSH terms
- Anticholesteremic Agents, Cardiovascular Diseases, Clinical Trials as Topic, Humans, Lipids, Terpenes, Hydroxymethylglutaryl-CoA Reductase Inhibitors
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