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Cited by 164Diabetes Treatment and ManagementIon Transport and Channel RegulationMetabolism, Diabetes, and Cancer

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Sodium-glucose cotransport

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Poulsen, Søren Brandt, Fenton, Robert A., Rieg, Timo·2015·Current Opinion in Nephrology and Hypertension
DOI 10.1097/mnh.0000000000000152PMC PMC5364028
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Abstract

PURPOSE OF REVIEW: Sodium-glucose cotransporters (SGLTs) are important mediators of glucose uptake across apical cell membranes. SGLT1 mediates almost all sodium-dependent glucose uptake in the small intestine, while in the kidney SGLT2, and to a lesser extent SGLT1, account for more than 90% and nearly 3%, respectively, of glucose reabsorption from the glomerular ultrafiltrate. Although the recent availability of SGLT2 inhibitors for the treatment of diabetes mellitus has increased the number of clinical studies, this review has a focus on mechanisms contributing to the cellular regulation of SGLTs. RECENT FINDINGS: Studies have focused on the regulation of SGLT expression under different physiological/pathophysiological conditions, for example diet, age or diabetes mellitus. Several studies provide evidence of SGLT regulation via cyclic adenosine monophosphate/protein kinase A, protein kinase C, glucagon-like peptide 2, insulin, leptin, signal transducer and activator of transcription-3 (STAT3), phosphoinositide-3 kinase (PI3K)/Akt, mitogen-activated protein kinases (MAPKs), nuclear factor-kappaB (NF-kappaB), with-no-K[Lys] kinases/STE20/SPS1-related proline/alanine-rich kinase (Wnk/SPAK) and regulatory solute carrier protein 1 (RS1) pathways. SUMMARY: SGLT inhibitors are important drugs for glycemic control in diabetes mellitus. Although the contribution of SGLT1 for absorption of glucose from the intestine as well as SGLT2/SGLT1 for renal glucose reabsorption has been comprehensively defined, this review provides an up-to-date outline for the mechanistic regulation of SGLT1/SGLT2.

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Metadata

Authors
Poulsen, S. B., Fenton, R. A., & Rieg, T.
Affiliations
  • Aarhus University (DK)
  • University of California San Diego (US)
Corresponding author
Rieg, Timo
ORCID
Venue
Current Opinion in Nephrology and Hypertension
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2015-09
Volume
24
Issue
5
Pages
463-469
ISSN
1062-4821 (ISSN-L)
DOI
10.1097/mnh.0000000000000152
PMC
PMC5364028
OpenAlex
W2397061303
Cited by
164
References
4
Citations by year
2026: 6 · 2025: 20 · 2024: 18 · 2023: 23 · 2022: 16 · 2021: 33 · 2020: 10 · 2019: 14 · 2018: 8 · 2017: 7 · 2016: 6 · 2015: 3
FWCI
1.21
Type
journal article
Language
en
Open access
Locations
  • Current Opinion in Nephrology & Hypertension (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (P30DK063491)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords
sodium-glucose cotransporter, SGLT1, SGLT2, glucose reabsorption, renal glucose reabsorption, intestinal glucose absorption, SGLT2 inhibitors, diabetes mellitus, protein kinase C, glucagon-like peptide-2, insulin, leptin, STAT3, PI3K/Akt, mitogen-activated protein kinase, NF-κB, RS1, glycemic control
MeSH terms
Animals, Blood Glucose, Glucose, Humans, Hypoglycemic Agents, Kidney, Sodium, Sodium-Glucose Transport Proteins

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