Physiologic, pathophysiologic, and pharmacologic regulation of gastric acid secretion

Proton pump inhibitors affect the gut microbiome

Imhann, F., Bonder, M. J., Vich Vila, A., Fu, J., Mujagic, Z., Vork, L., Tigchelaar, E. F., Jankipersadsing, S. A., Cenit, M. C., Harmsen, H. J. M., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-310376 · Cited by 1,371

The Risks and Benefits of Long-term Use of Proton Pump Inhibitors: Expert Review and Best Practice Advice From the American Gastroenterological Association

Freedberg, D. E., Kim, L. S., & Yang, Y. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.01.031 · Cited by 933

Proton pump inhibitors alter the composition of the gut microbiota

Jackson, M. A., Goodrich, J. K., Maxan, M.-E., Freedberg, D. E., Abrams, J. A., Poole, A. C., Sutter, J. L., Welter, D., Ley, R. E., Bell, J. T., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-310861 · Cited by 895

Proton Pump Inhibitor Use and the Risk of Chronic Kidney Disease

Lazarus, B., Chen, Y., Wilson, F. P., Sang, Y., Chang, A. R., Coresh, J., & Grams, M. E. (2016) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2015.7193 · Cited by 745

Proton Pump Inhibitors Exacerbate NSAID-Induced Small Intestinal Injury by Inducing Dysbiosis

Wallace, J. L., Syer, S., Denou, E., de Palma, G., Vong, L., McKnight, W., Jury, J., Bolla, M., Bercik, P., Collins, S. M., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.06.075 · Cited by 460

The vagus nerve in appetite regulation, mood, and intestinal inflammation

Browning, K. N., Verheijden, S., & Boeckxstaens, G. E. (2017) · Gastroenterology · doi:10.1053/j.gastro.2016.10.046 · Cited by 361

Potent acid inhibition by vonoprazan in comparison with esomeprazole, with reference to CYP 2C19 genotype

Kagami, T., Sahara, S., Ichikawa, H., Uotani, T., Yamade, M., Sugimoto, M., Hamaya, Y., Iwaizumi, M., Osawa, S., Sugimoto, K., et al. (2016) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13588 · Cited by 253

Use of Proton Pump Inhibitors and Risks of Fundic Gland Polyps and Gastric Cancer: Systematic Review and Meta-analysis

Tran‐Duy, A., Spaetgens, B., Hoes, A. W., de Wit, N. J., & Stehouwer, C. D. A. (2016) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2016.05.018 · Cited by 209

Proton pump inhibitors as a risk factor for hepatic encephalopathy and spontaneous bacterial peritonitis in patients with cirrhosis with ascites

Dam, G., Vilstrup, H., Watson, H., & Jepsen, P. (2016) · Hepatology · doi:10.1002/hep.28737 · Cited by 190

A comparison of the gut microbiome between long‐term users and non‐users of proton pump inhibitors

Clooney, A. G., Bernstein, C. N., Leslie, W. D., Vagianos, K., Sargent, M., Laserna‐Mendieta, E. J., Claesson, M. J., & Targownik, L. E. (2016) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13568 · Cited by 166

Proton Pump Inhibitor and Histamine-2 Receptor Antagonist Use and Iron Deficiency

Lam, J. R., Schneider, J. L., Quesenberry, C. P., & Corley, D. A. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.11.023 · Cited by 154

Gastrin and Gastric Cancer

Waldum, H. L., Sagatun, L., & Mjønes, P. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00001 · Cited by 142

A Review of the Novel Application and Potential Adverse Effects of Proton Pump Inhibitors

Yu, L., Sun, L., Zhang, X., Li, Y.-Q., Yu, L., Yuan, Z.-Q.-Y., Meng, L., Zhang, H., & Wang, Y. (2017) · Advances in Therapy · doi:10.1007/s12325-017-0532-9 · Cited by 141

Proton Pump Inhibitors Increase Incidence of Nonsteroidal Anti-Inflammatory Drug–Induced Small Bowel Injury: A Randomized, Placebo-Controlled Trial

Washio, E., Esaki, M., Maehata, Y., Miyazaki, M., Kobayashi, H., Ishikawa, H., Kitazono, T., & Matsumoto, T. (2015) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2015.10.022 · Cited by 129

Randomised clinical trial: efficacy and safety of vonoprazan vs. lansoprazole in patients with gastric or duodenal ulcers – results from two phase 3, non‐inferiority randomised controlled trials

Miwa, H., Uedo, N., Watari, J., Mori, Y., Sakurai, Y., Takanami, Y., Nishimura, A., Tatsumi, T., & Sakaki, N. (2016) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13876 · Cited by 123

Characteristics of the Novel Potassium-Competitive Acid Blocker Vonoprazan Fumarate (TAK-438)

Otake, K., Sakurai, Y., Nishida, H., Fukui, H., Tagawa, Y., Yamasaki, H., Karashima, M., Otsuka, K., & Inatomi, N. (2016) · Advances in Therapy · doi:10.1007/s12325-016-0345-2 · Cited by 101

Proton-Pump Inhibitors Reduce Gastrointestinal Events Regardless of Aspirin Dose in Patients Requiring Dual Antiplatelet Therapy

Vaduganathan, M., Bhatt, D. L., Cryer, B., Liu, Y., Hsieh, W.-H., Doros, G. D., Cohen, M. C., Lanas, Á., Schnitzer, T. J., Shook, T., et al. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.12.068 · Cited by 93

Systematic review with meta‐analysis: fundic gland polyps and proton pump inhibitors

Martin, F. C., Chenevix‐Trench, G., & Yeomans, N. D. (2016) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13800 · Cited by 90

Helicobacter pylori and gastric acid: an intimate and reciprocal relationship

Waldum, H. L., Kleveland, P. M., & Sørdal, Ø. F. (2016) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x16663395 · Cited by 81

Proton pump inhibitors and osteoporosis

Andersen, B. N., Johansen, P. B., & Abrahamsen, B. (2016) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000291 · Cited by 75

Helicobacter pylori-Induced Changes in Gastric Acid Secretion and Upper Gastrointestinal Disease

Smolka, A. J., & Schubert, M. L. (2017) · Current topics in microbiology and immunology · doi:10.1007/978-3-319-50520-6_10 · Cited by 74

Proton pump inhibitor monotherapy and the risk of cardiovascular events in patients with gastro‐esophageal reflux disease: a meta‐analysis

Sun, S., Cui, Z.-M., Zhou, M., Li, R., Li, H., Zhang, S., Ba, Y., & Cheng, G. (2016) · Neurogastroenterology & Motility · doi:10.1111/nmo.12926 · Cited by 69

Targeted Apoptosis of Parietal Cells Is Insufficient to Induce Metaplasia in Stomach

Burclaff, J., Osaki, L. H., Liu, D., Goldenring, J. R., & Mills, J. C. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.12.001 · Cited by 68

Gastrin stimulates a cholecystokinin-2-receptor-expressing cardia progenitor cell and promotes progression of Barrett's-like esophagus

Lee, Y., Urbanska, A. M., Hayakawa, Y., Wang, H., Au, A. S., Luna, A. M., Chang, W., Jin, G., Bhagat, G., Abrams, J. A., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.10667 · Cited by 67

Netazepide, a gastrin/cholecystokinin‐2 receptor antagonist, can eradicate gastric neuroendocrine tumours in patients with autoimmune chronic atrophic gastritis

Boyce, M. J., Moore, A. R., Sagatun, L., Parsons, B. N., Varró, A., Campbell, F., Fossmark, R., Waldum, H. L., & Pritchard, D. M. (2016) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.13146 · Cited by 67

Gastrin and upper GI cancers

Hayakawa, Y., Chang, W., Jin, G., & Wang, T. C. (2016) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2016.08.013 · Cited by 65

Histamine H 2 Receptor Antagonists, Left Ventricular Morphology, and Heart Failure Risk

Leary, P. J., Tedford, R. J., Bluemke, D. A., Bristow, M. R., Heckbert, S. R., Kawut, S. M., Krieger, E. V., Lima, J. A. C., Masri, C. S., Ralph, D. D., et al. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.01.045 · Cited by 65

Opened Proton Pump Inhibitor Capsules Reduce Time to Healing Compared With Intact Capsules for Marginal Ulceration Following Roux-en-Y Gastric Bypass

Schulman, A. R., Chan, W. W., Devery, A., Ryan, M. B., & Thompson, C. C. (2016) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2016.10.015 · Cited by 63

Pancreatic β-Cells Express the Fetal Islet Hormone Gastrin in Rodent and Human Diabetes

Dahan, T., Ziv, O., Horwitz, E. P., Zemmour, H., Lavi, J., Swisa, A., Leibowitz, G., Ashcroft, F. M., Veld, P. I. '., Gläser, B., et al. (2016) · Diabetes · doi:10.2337/db16-0641 · Cited by 62

Advances in the diagnosis and treatment of pancreatic neuroendocrine neoplasms in Japan

Ito, T., Hijioka, S., Masui, T., Kasajima, A., Nakamoto, Y., Kobayashi, N., Komoto, I., Hijioka, M., Lee, L., Igarashi, H., et al. (2016) · Journal of Gastroenterology · doi:10.1007/s00535-016-1250-9 · Cited by 59

Molecular imaging in neuroendocrine tumors: recent advances, controversies, unresolved issues, and roles in management

Ito, T., & Jensen, R. T. (2016) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000300 · Cited by 59

Association of Proton Pump Inhibitors With Risk of Dementia: A Pharmacoepidemiological Claims Data Analysis.

Gomm, W., von Holt, K., Thomé, F., Broich, K., Maier, W., Fink, A., Doblhammer‐Reiter, G., & Haenisch, B. (2016) · DZNE Pub · Cited by 59

Long-Term PPI Use: Balancing Potential Harms and Documented Benefits

Laine, L., & Nagar, A. B. (2016) · The American Journal of Gastroenterology · doi:10.1038/ajg.2016.156 · Cited by 54

Pathophysiology and laboratory diagnosis of pernicious anemia

Toh, B. (2016) · Immunologic Research · doi:10.1007/s12026-016-8841-7 · Cited by 54

Solitary Gastric Carcinoid Tumor Associated with Long-Term Use of Omeprazole: A Case Report and Review of the Literature

Nandy, N., Hanson, J. A., STRICKLAND, R. G., & McCarthy, D. M. (2015) · Digestive Diseases and Sciences · doi:10.1007/s10620-015-4014-0 · Cited by 52

How May Proton Pump Inhibitors Impair Cardiovascular Health?

Sukhovershin, R. A., & Cooke, J. P. (2016) · American Journal of Cardiovascular Drugs · doi:10.1007/s40256-016-0160-9 · Cited by 50

Acute resistance exercise induces Sestrin2 phosphorylation and p62 dephosphorylation in human skeletal muscle

Zeng, N., D’Souza, R. F., Figueiredo, V. C., Markworth, J. F., Roberts, L. A., Peake, J. M., Mitchell, C. J., & Cameron‐Smith, D. (2017) · Physiological Reports · doi:10.14814/phy2.13526 · Cited by 47

Proton pump inhibitors use and change in bone mineral density

Arj, A., Zadeh, M. R., Yavari, M., Akbari, H., Zamani, B., & Asemi, Z. (2016) · International Journal of Rheumatic Diseases · doi:10.1111/1756-185x.12866 · Cited by 46

Pharmacokinetics and Safety of Triple Therapy with Vonoprazan, Amoxicillin, and Clarithromycin or Metronidazole: A Phase 1, Open-Label, Randomized, Crossover Study

Sakurai, Y., Shiino, M., Okamoto, H., Nishimura, A., Nakamura, K., & Hasegawa, S. (2016) · Advances in Therapy · doi:10.1007/s12325-016-0374-x · Cited by 43

The impact of proton pump inhibitor therapy on patients with liver disease

Cole, H. L., Pennycook, S., & Hayes, P. C. (2016) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13827 · Cited by 42

ECL‐cell carcinoids and carcinoma in patients homozygous for an inactivating mutation in the gastric H + K + ATPase alpha subunit

Fossmark, R., Calvete, O., Mjønes, P., Benitez, J. J., & Waldum, H. L. (2016) · Apmis · doi:10.1111/apm.12546 · Cited by 40

The Diagnostic Value of Gastrin-17 Detection in Atrophic Gastritis

Wang, X., Ling, L., Li, S., Qin, G., Cui, W., Li, X., & Ni, H. (2016) · Medicine · doi:10.1097/md.0000000000003599 · Cited by 36

Histamine H2-Blocker and Proton Pump Inhibitor Use and the Risk of Pneumonia in Acute Stroke: A Retrospective Analysis on Susceptible Patients

Arai, N., Nakamizo, T., Ihara, H., Koide, T., Nakamura, A., Tabuse, M., & Miyazaki, H. (2017) · PLoS ONE · doi:10.1371/journal.pone.0169300 · Cited by 35

Common single nucleotide polymorphisms in transient receptor potential melastatin type 6 increase the risk for proton pump inhibitor-induced hypomagnesemia

Hess, M. W., de Baaij, J. H. F., Broekman, M. M. T. J., Bisseling, T. M., Haarhuis, B., Tan, A. C. I. T. L., Morsche, R. H. M. T., Hoenderop, J. G. J., Bindels, R. J. M., & Drenth, J. P. H. (2016) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0000000000000259 · Cited by 34

Gastrin activates autophagy and increases migration and survival of gastric adenocarcinoma cells

Rao, S. V., Solum, G., Niederdorfer, B., Nørsett, K. G., Bjørkøy, G., & Thommesen, L. (2017) · BMC Cancer · doi:10.1186/s12885-017-3055-5 · Cited by 34

Proton Pump Inhibitors Are Not Associated With Acute Kidney Injury in Critical Illness

Lee, J., Mark, R. G., Celi, L. A., & Danziger, J. (2016) · The Journal of Clinical Pharmacology · doi:10.1002/jcph.805 · Cited by 31

Potential clinical indications for a CCK2 receptor antagonist

Boyce, M. J., Lloyd, K., & Pritchard, D. M. (2016) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2016.09.002 · Cited by 29

Fatty acids in a high-fat diet potentially induce gastric parietal-cell damage and metaplasia in mice

Hirata, Y., Sezaki, T., Tamura‐Nakano, M., Oyama, C., Hagiwara, T., Ishikawa, T., Fukuda, S., Yamada, K., Higuchi, K., Dohi, T., et al. (2016) · Journal of Gastroenterology · doi:10.1007/s00535-016-1291-0 · Cited by 28

Effects of long-term administration of pantoprazole on bone mineral density in young male rats

Matuszewska, A., Nowak, B., Rzeszutko, M., Zduniak, K., Szandruk-Bender, M., Jędrzejuk, D., Landwójtowicz, M., Bolanowski, M., Pieśniewska, M., Kwiatkowska, J., et al. (2016) · Pharmacological Reports · doi:10.1016/j.pharep.2016.06.012 · Cited by 25

Inhibiting the proton pump: mechanisms, benefits, harms, and questions

Aronson, J. K. (2016) · BMC Medicine · doi:10.1186/s12916-016-0724-1 · Cited by 22

Radiographic Localization Study of a Novel Potassium-Competitive Acid Blocker, Vonoprazan, in the Rat Gastric Mucosa

Matsukawa, J., Kogame, A., Tagawa, Y., & Inatomi, N. (2016) · Digestive Diseases and Sciences · doi:10.1007/s10620-016-4100-y · Cited by 21

Gastric acid secretion and gastrin release during continuous vagal neuromonitoring in thyroid surgery

Xiaoli, L., Wu, C., Kim, H. Y., Tian, W., Chiang, F., Liu, R., Anuwong, A., Randolph, G. W., Dionigi, G., & Lavazza, M. (2017) · Langenbeck s Archives of Surgery · doi:10.1007/s00423-017-1555-z · Cited by 21

Association between Increased Gastric Juice Acidity and Sliding Hiatal Hernia Development in Humans

Kishikawa, H., Kimura, K., Ito, A., Arahata, K., Takarabe, S., Kaida, S., Kanai∥, T., Miura, S., & Nishida, J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170416 · Cited by 20

Novel function of histamine signaling via histamine receptors in cholesterol and bile acid metabolism: Histamine H2 receptor protects against nonalcoholic fatty liver disease

Yamada, S., Guo, X., Wang, K., Tanimoto, A., & Sasaguri, Y. (2016) · Pathology International · doi:10.1111/pin.12423 · Cited by 19

Unique Cellular Lineage Composition of the First Gland of the Mouse Gastric Corpus

O’Neil, A., Petersen, C. P., Choi, E.-Y. K., Engevik, A. C., & Goldenring, J. R. (2016) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155416678182 · Cited by 18

The Gastrointestinal Tract Microbiota and Allergic Diseases

Kyburz, A., & Mueller, A. (2016) · Digestive Diseases · doi:10.1159/000443357 · Cited by 17

CCK, Gastrin and Diabetes Mellitus

Rehfeld, J. F. (2016) · Biomarkers in Medicine · doi:10.2217/bmm-2016-0175 · Cited by 17

Heterogeneous expression of cholecystokinin and gastrin receptor in stomach and pancreatic cancer: An immunohistochemical study

Rai, R., Kim, J.-J., Tewari, M., & Shukla, H. (2016) · Journal of Cancer Research and Therapeutics · doi:10.4103/0973-1482.168970 · Cited by 15

Zinc Ions Mediate Gastrin Expression, Proliferation, and Migration Downstream of the Cholecystokinin-2 Receptor

Chang, M. S. S., Xiao, L., Shulkes, A., Baldwin, G. S., & Patel, O. (2016) · Endocrinology · doi:10.1210/en.2016-1270 · Cited by 15

Advances in the Diagnosis of Neuroendocrine Neoplasms

Kulkarni, H., Singh, A., & Baum, R. P. (2016) · Seminars in Nuclear Medicine · doi:10.1053/j.semnuclmed.2016.06.001 · Cited by 11

Do Proton Pump Inhibitors Exacerbate Nonsteroidal Anti-Inflammatory Drug-Induced Small-Bowel Enteropathy?

Chan, F. K. L. (2016) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2016.02.005 · Cited by 7

Vonoprazan: MarKed Competition for PPIs?

Scott, D. R., Marcus, E. A., & Sachs, G. M. (2016) · Digestive Diseases and Sciences · doi:10.1007/s10620-016-4164-8 · Cited by 7

Gastric acid response to acute exposure to hypergravity

Yoon, G., & Kim, H. S. (2016) · Oncotarget · doi:10.18632/oncotarget.13969 · Cited by 7

Acute effects of N‐terminal progastrin fragments on gastric acid secretion in man

Goetze, J. P., Hansen, C. P., & Rehfeld, J. F. (2017) · Physiological Reports · doi:10.14814/phy2.13164 · Cited by 3

Molecular Mechanisms of Iron and Heme Metabolism

Dutt, S., Hamza, I., & Bartnikas, T. B. (2022) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-062320-112625 · Cited by 360

Bioinspired oral delivery of gut microbiota by self-coating with biofilms

Wang, X., Cao, Z., Zhang, M., Meng, L., Ming, Z., & Liu, J. (2020) · Science Advances · doi:10.1126/sciadv.abb1952 · Cited by 258

Engineered probiotic ameliorates ulcerative colitis by restoring gut microbiota and redox homeostasis

Guo, P., Wang, W., Xiang, Q., Pan, C., Qiu, Y., Li, T., Wang, D., Ouyang, J., Jia, R., Shi, M., et al. (2024) · Cell Host & Microbe · doi:10.1016/j.chom.2024.07.028 · Cited by 199

Mast cell activation syndrome and mastocytosis: initial treatment options and long-term management

Castells, M., & Butterfield, J. (2019) · The Journal of Allergy and Clinical Immunology: In Practice · doi:10.1016/j.jaip.2019.02.002 · Cited by 135

Systematic review: the effects of proton pump inhibitors on the microbiome of the digestive tract—evidence from next‐generation sequencing studies

Macke, L., Schulz, C., Koletzko, L., & Malfertheiner, P. (2020) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15604 · Cited by 118

Kaempferol protects ethanol-induced gastric ulcers in mice via pro-inflammatory cytokines and NO

Li, Q., Hu, X., Xuan, Y.-H., Ying, J., Fei, Y., Rong, J., Zhang, Y., Zhang, J., Liu, C., & Liu, Z. (2018) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmy002 · Cited by 104

Histamine Intolerance Originates in the Gut

Schnedl, W. J., & Enko, D. (2021) · Nutrients · doi:10.3390/nu13041262 · Cited by 95

Autoimmune Atrophic Gastritis: A Clinical Review

Castellana, C., Eusebi, L. H., Dajti, E., Iascone, V., Vestito, A., Fusaroli, P., Fuccio, L., D’Errico, A., & Zagari, R. M. (2024) · Cancers · doi:10.3390/cancers16071310 · Cited by 86

Safranal, a constituent of saffron, exerts gastro-protective effects against indomethacin-induced gastric ulcer

Tamaddonfard, E., Erfanparast, A., Farshid, A. A., Imani, M., Mirzakhani, N., Salighedar, R., & Tamaddonfard, S. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.03.054 · Cited by 78

The Gastroprotective Effect of Naringenin against Ethanol-Induced Gastric Ulcers in Mice through Inhibiting Oxidative and Inflammatory Responses

Li, W.-S., Lin, S., Chu, C.-H., Chang, Y., Zhang, X., Lin, C., & Tung, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111985 · Cited by 76

Assessment of Yeasts as Potential Probiotics: A Review of Gastrointestinal Tract Conditions and Investigation Methods

Alkalbani, N. S., Osaili, T. M. I., Al‐Nabulsi, A. A., Olaimat, A. N., Liu, S., Shah, N. P., Apostolopoulos, V., & Ayyash, M. M. (2022) · Journal of Fungi · doi:10.3390/jof8040365 · Cited by 73

Side effects of long-term use of proton pump inhibitors: practical considerations

Castellana, C., Pecere, S., Furnari, M., Telese, A., Matteo, M. V., Haidry, R. J., & Eusebi, L. H. (2021) · Polskie Archiwum Medycyny Wewnętrznej · doi:10.20452/pamw.15997 · Cited by 66

Natural deep eutectic solvent (NADES)-based blueberry extracts protect against ethanol-induced gastric ulcer in rats

da Silva, D. T., Rodrigues, R. F., Machado, N. M., Maurer, L. H., Ferreira, L. F., Somacal, S., da Veiga, M. L., da Rocha, M. I. D. U. M., Vizzotto, M., Rodrigues, E., et al. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109718 · Cited by 64

Recent progress of micro/nanomotors to overcome physiological barriers in the gastrointestinal tract

Zhang, S., Zhu, C., Huang, W., Liu, H., Yang, M., Zeng, X., Zhang, Z., Liu, J., Shi, J., Hu, Y., et al. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.07.005 · Cited by 58

Common Pitfalls in the Management of Patients with Micronutrient Deficiency: Keep in Mind the Stomach

Carabotti, M., Annibale, B., & Lahner, E. (2021) · Nutrients · doi:10.3390/nu13010208 · Cited by 56

Considering histamine in functional gastrointestinal disorders

Schnedl, W. J., & Enko, D. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1791049 · Cited by 47

Conformational fidelity and hydrogen bond associability of L-histidine with sulfamate anion studied through XRD, quantum chemical, spectroscopic and molecular docking simulation as a cdk-4 inhibitor against retinoblastoma

Zochedh, A., Athimoolam, S., & Bahadur, S. A. (2022) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2022.134402 · Cited by 46

In Terms of Nutrition, the Most Suitable Method for Bariatric Surgery: Laparoscopic Sleeve Gastrectomy or Roux-en-Y Gastric Bypass? A Systematic Review and Meta-analysis

Gu, L., Fu, R., Chen, P., Du, N., Chen, S., Mao, D., Chen, B., Mao, F., Khadaroo, P. A., & Jin, Q. (2020) · Obesity Surgery · doi:10.1007/s11695-020-04488-2 · Cited by 44

ETA guidelines for the use of levothyroxine sodium preparations in monotherapy to optimize the treatment of hypothyroidism

Centanni, M., Duntas, L., Feldt-Rasmussen, U., Koehrle, J., Peeters, R. P., Razvi, S., Trimboli, P., & Virili, C. (2025) · European Thyroid Journal · doi:10.1530/etj-25-0123 · Cited by 38

Esomeprazole alleviates the damage to stress ulcer in rats through not only its antisecretory effect but its antioxidant effect by inactivating the p38 MAPK and NF-κB signaling pathways

Xie, W., Huang, X., Chen, R., Chen, R., Tang, L., Wu, W., & Huang, Z. (2019) · Drug Design Development and Therapy · doi:10.2147/dddt.s193641 · Cited by 33

Chronic brain histamine depletion in adult mice induced depression-like behaviours and impaired sleep-wake cycle

Yamada, Y., Yoshikawa, T., Naganuma, F., Kikkawa, T., Osumi, N., & Yanai, K. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108179 · Cited by 31

Benign and malignant gastroduodenal diseases associated with Helicobacter pylori: a narrative review and personal remarks in 2018

Buzás, G. M. (2018) · Minerva Gastroenterologica e Dietologica · doi:10.23736/s1121-421x.18.02481-9 · Cited by 28

Achillea millefolium Essential Oil Mitigates Peptic Ulcer in Rats through Nrf2/HO-1 Pathway

Alomair, M. K., Alabduladheem, L. S., Almajed, M. A., Alobaid, A. A., Alkhalifah, E. A. R., Younis, N. S., & Mohamed, M. E. (2022) · Molecules · doi:10.3390/molecules27227908 · Cited by 28

Allergen Stability in Food Allergy: A Clinician’s Perspective

Koidl, L., Gentile, S. A., & Untersmayr, E. (2023) · Current Allergy and Asthma Reports · doi:10.1007/s11882-023-01107-9 · Cited by 27

Effects of eradicating Helicobacter pylori on metachronous gastric cancer prevention: A systematic review and meta‐analysis

Fan, F., Wang, Z., Li, B., & Zhang, H. (2019) · Journal of Evaluation in Clinical Practice · doi:10.1111/jep.13179 · Cited by 25

Autonomously Assembled Living Capsules by Microbial Coculture for Enhanced Bacteriotherapy of Inflammatory Bowel Disease

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Adverse effects of proton pump inhibitors

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Autoimmune Gastritis and Hypochlorhydria: Known Concepts from a New Perspective

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Helicobacter pylori Related Diseases and Osteoporotic Fractures (Narrative Review)

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Molecular Mechanisms of Iron Metabolism and Overload

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Inhibition of gastric acid secretion with omeprazole affects fish specific dynamic action and growth rate: Implications for the development of phenotypic stomach loss

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Risk Factors Associated With Upper Aerodigestive Tract or Coliform Bacterial Overgrowth of the Small Intestine in Symptomatic Patients

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Gastrin/CCK-B Receptor Signaling Promotes Cell Invasion and Metastasis by Upregulating MMP-2 and VEGF Expression in Gastric Cancer

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Grosvenorine (Monk Fruit flavonoid) Attenuates Indomethacin-mediated Gastropathy in Vivo: Role of P53/Bcl-2, Antioxidant, and Inflammatory Mediators

Ahmed, K. A., Alqaisi, K. M., Jabbar, A. A., Ismail, P. A., Ibrahim, N. A., Althagbi, H. I., Hassan, R. R., Saber, M. H., Saleh, G. N., saleh, M. I., et al. (2025) · Journal of Pharmaceutical Innovation · doi:10.1007/s12247-025-10115-3 · Cited by 14

Snail Mucus Protective Effect on Ethanol-Induced Gastric Ulcers in Mice

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Extra-gastric expression of the proton pump H+/K+ -ATPase in the gills and kidney of the teleost Oreochromis niloticus

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Gastro-Protective Effect of Fermented Soybean (Glycine max (L.) Merr.) in a Rat Model of Ethanol/HCl-Induced Gastric Injury

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Gut microbiota composition alteration analysis and functional categorization in children with growth hormone deficiency

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Parthenolide alleviates indomethacin-induced gastric ulcer in rats via antioxidant, anti-inflammatory, and antiapoptotic activities

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Untargeted serum and gastric metabolomics and network pharmacology analysis reveal the superior efficacy of zingiberis rhizoma recens-/euodiae fructus-processed Coptidis Rhizoma on gastric ulcer rats

Zhang, Z., Zheng, Y., Zhang, B., Wang, R., Chen, L., Wang, Y., Weisheng, F. E. N. G., Zheng, X., Li, K., & Zhou, N. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118376 · Cited by 9

Tegoprazan: a novel, highly selective, and potent potassium-competitive acid blocker (P-CAB)

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Exploring the Underlying Mechanisms of Preventive Treatment Related to Dietary Factors for Gastric Diseases

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Serum gastrin-17 concentration for prediction of upper gastrointestinal tract bleeding risk among peptic ulcer patients

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Adverse Reaction Signals Mining of Vonoprazan: A Pharmacovigilance Study Based on FAERS

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The chemical constituents and gastroprotective effects of Calanthe fimbriata Franch

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The gastric acid acidity quantitative evaluation approach through luminescence material BaSO4:V5+

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Prevalence of Self-medication for Acid Peptic Disease amongst People of Manawa, Lahore

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Refining the Correa cascade: Gastric stem cell plasticity, niche remodelling, and parallel pathways to neoplasia

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Gastroprotective effects of Heracleum persicum hydroethanolic extract against ethanol-induced gastric ulcer in rats via suppressing oxidative stress and apoptosis

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QiangGuYin Modulates the OPG/RANKL/RANK Pathway by Increasing Secretin Levels during Treatment of Primary Type I Osteoporosis

Li, X., Cui, L., Chen, W., Fang, Y., Shen, G., Li, Z., Zhang, B., & Wu, L. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/7114139 · Cited by 4

Helicobacter pylori infection and lactose intolerance increase expiratory hydrogen

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Current status and prospects of using potassium-competitive acid blockers in gastroenterology

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Effects of CYP2C19 Polymorphism on Metabolism and Effectiveness of Proton Pump Inhibitors: A Review of Clinical and Laboratory Studies

Neumoina, M. V., Shmakova, T. V., Михайловна, П. К., Neumoina, N. V., Shutova, I. V., Львовна, Д. Т., & Troshina, T. A. (2021) · ЗДОРОВЬЕ НАСЕЛЕНИЯ И СРЕДА ОБИТАНИЯ - ЗНиСО / PUBLIC HEALTH AND LIFE ENVIRONMENT · doi:10.35627/2219-5238/2021-337-4-66-73 · Cited by 4

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Protective role of alkaloids of Calanthe fimbriata against ethanol-induced gastric ulcer in mice: Involvement of anti-gastric acid secretion and suppression of NF-κB/MAPK inflammatory cascades

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Aibika Flower Flavonoid Extract Exhibits Antiulcer Activity in a Murine Model of Ethanol-Induced Acute Gastric Injury

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Computational Evaluation of the Potential of Salicylate Compound from Syzygium aromaticum on Carbonic Anhydrase I as a Gastric Acid Stimulant

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Pomegranate as a natural remedy for gastric ulcers prevention: a review of its gastroprotective mechanisms and pharmacological benefits

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Potential of Adora2b as an immunotherapeutic target for gastric cancer

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Changes of Gastric Juice Microenvironment in Patients with Fundic Gland Polyp and Hyperplastic Polyp

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Digestion—Absorption

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Prediction of gastroesophageal reflux episodes by smooth muscle electromyography: A translational study in rats and adolescents

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Risk Factors for Gastrointestinal Injuries in Acute Coronary Syndrome Patients with Double Antiplatelet Therapy in One-Year Follow-Up

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In search of the grail: A race for acid suppression

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Gastrointestinal Physiology and Aging

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Evaluation of Anti-oxidant and Anti-ulcerogenic activity of Cannabis Sativa extract against aspirin-induced gastric ulcer in Rabbits

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mosGraphFlow: a novel integrative graph AI model mining disease targets from multi-omic dataPreprint

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A case study on the proton pump inhibitor omeprazole

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Gastric Cancer in the Post-Helicobacter pylori Era: Non-H. pylori-Related Gastric Microbiota, Non-H. pylori-Related and Post-H. pylori Eradication Gastric Cancer

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In vitro Bioaccesibility of Phenolic Compounds from the Halophytes Suaeda Edulis and Suaeda Esteroa: Opportunity for the Development of Novel Foods

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Gastrointestinal Physiology and Aging

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Developmental Anatomy and Physiology of the Stomach

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Factors associated with iron deficiency and how they can be used in blood donor selection processesPreprint

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La búsqueda del Grial: una carrera por la supresión ácida

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STUDY OF ANTISECRETORY ACTIVITY OF DINITRATE 2-PHENYL-9-DIETHYLAMINOETHYLimidazo[1,2-A] BENZIMIDAZOLE BY METHOD OF CONTINUOUS PERFUSION OF RATS’ STOMACHS

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Sporadische und familiäre neuroendokrine Tumoren des Magens

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Digestion and inflammatory responses

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Novel sites of CCK2R expression

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Sporadische und familiäre neuroendokrine Tumoren des Magens

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Acid Suppressive Therapy

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Sporadische und familiäre neuroendokrine Tumoren des Magens

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Behavioural Teratogenic Effect of Cimetidine on the Offspring’s of Albino Rats

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The Promising Therapeutic Effects of Pomegranate (Punica granatum) on Gastric Ulcers: A Comprehensive Review on Antioxidant, Anti-inflammatory Properties and Molecular MechanismsPreprint

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Developmental Anatomy and Physiology of the Stomach

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Physiology and Function of the Upper GI Tract

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Circulating Helicobacter pylori extracellular vesicles in serum as biomarkers of infection

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Anti-acid and anti-secretory activities of the aqueous extract of Microdesmis keayana J. Léonard (Pandaceae) leaves on gastric hypersecretion induced in Wistar rats

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ASSOCIATION BETWEEN CHRONIC USE OF POTASSIUM-COMPETITIVE ACID BLOCKERS (P-CABs) AND THE DEVELOPMENT OF GASTRIC POLYPS: AN INTEGRATIVE LITERATURE REVIEW

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