The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
New insights in the control of vascular permeability: vascular endothelial-cadherin and other players
Abstract
PURPOSE OF REVIEW: The control of the endothelial barrier function is essential for vascular homeostasis and is mainly mediated by cell-to-cell junctions that tightly regulate permeability to plasma solutes and circulating cells such as leukocytes and tumor cells. While in some circumstances the transient dismantling of endothelial cell junctions might be beneficial, in pathological conditions, such as cancer, severe alterations of endothelial junction composition and function are detrimental, causing massive edema and increased interstitial pressure. Here, we aim to discuss the newly and most recently identified molecular mechanisms that cooperate in the control of vascular permeability. RECENT FINDINGS: Although the involvement of vascular endothelial-cadherin in the regulation of vascular leakage is well known, recent findings shed light on additional molecules involved in the control of vascular endothelial-cadherin phosphorylation in physiological and pathological conditions, and identified new unknown regulators of the endothelial barrier function. SUMMARY: In the past years, several studies explored the contribution of various signaling pathways in the regulation of vascular leakage. Despite encouraging results, a more comprehensive understanding of the molecular mechanisms involved in this process will define druggable targets for new therapeutic interventions to limit endothelial barrier dysfunctions.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“These inflammatory agents activate signals that converge on common downstream pathways, including dismantling of vascular endothelial (VE)-cadherin (Cadherin 5, CDH5) from EC–EC junctions (4, 5).”
From Targeting β1-integrin inhibits vascular leakage in endotoxemia (2018) · cites this paper as [5]
In the citing paper
“Proinflammatory cytokines, microbial components such as lipopolysaccharide (LPS), thrombin, and vascular endothelial growth factor (VEGF) induce endothelial permeability by binding to their cognate receptors on ECs.”
From Targeting β1-integrin inhibits vascular leakage in endotoxemia (2018) · cites this paper as [5]
Citations
Cites
Angiogenesis in cancer and other diseases
Carmeliet, P., & Jain, R. K. (2000) · Nature · doi:10.1038/35025220 · Cited by 9,070
Pierce, K. L., Premont, R. T., & Lefkowitz, R. J. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm908 · Cited by 2,712
Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases
Carmeliet, P., & Jain, R. K. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3455 · Cited by 1,740
Normalization of the Vasculature for Treatment of Cancer and Other Diseases
Goel, S., Duda, D. G., Xu, L., Munn, L. L., Boucher, Y., Fukumura, D., & Jain, R. K. (2011) · Physiological Reviews · doi:10.1152/physrev.00038.2010 · Cited by 1,605
Gavard, J., & Gutkind, J. S. (2006) · Nature Cell Biology · doi:10.1038/ncb1486 · Cited by 1,057
VE-Cadherin and Endothelial Adherens Junctions: Active Guardians of Vascular Integrity
Giannotta, M., Trani, M., & Dejana, E. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.08.020 · Cited by 854
Self-citationTaddei, A., Giampietro, C., Conti, A., Orsenigo, F., Breviario, F., Pirazzoli, V., Potente, M., Daly, C., Dimmeler, S., & Dejana, E. (2008) · Nature Cell Biology · doi:10.1038/ncb1752 · Cited by 648
Self-citationArchitecture of tight junctions and principles of molecular composition
Van Itallie, C. M., & Anderson, J. M. (2014) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2014.08.011 · Cited by 544
Lampugnani, M. G., Orsenigo, F., Gagliani, M. C., Tacchetti, C., & Dejana, E. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200602080 · Cited by 521
Self-citationAbedi, H., & Zachary, I. C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.24.15442 · Cited by 478
Flagged first, then by citations
Research works printed but not linked: 1
- Weis, 2004, J Clin Invest, 113, 885, 10.1172/JCI200420702 · DOI
Cited by
Sorted by citations
Targeting β1-integrin inhibits vascular leakage in endotoxemia
Hakanpaa, L., Kiss, E. A., Jacquemet, G., Miinalainen, I., Lerche, M., Guzmán, C., Mervaala, E., Eklund, L., Ivaska, J., & Saharinen, P. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1722317115 · Cited by 95
“translocation of alpha(5)beta(1) integrins promotes early fibronectin fibrillogenesis.”
Background
Metadata
- Authors
- Trani, M., & Dejana, E.
- Affiliations
- University of Milan (IT)
- Corresponding author
- Dejana, Elisabetta
- ORCID
- Dejana, Elisabetta
- Venue
- Current Opinion in Hematology
- Published
- 2015-05
- Volume
- 22
- Issue
- 3
- Pages
- 267-272
- ISSN
- 1065-6251 (ISSN-L)
- OpenAlex
- W2039344188
- Cited by
- 52
- References
- 40
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 5 · 2020: 10 · 2019: 9 · 2018: 6 · 2017: 7 · 2016: 4 · 2015: 2
- FWCI
- 0.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Hematology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Associazione Italiana per la Ricerca sul Cancro
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- vascular permeability, endothelial barrier function, endothelial junctions, VE-cadherin, vascular leakage, leukocyte transendothelial migration, tumor cell extravasation, edema, interstitial fluid pressure, vascular homeostasis, signaling pathways, therapeutic target
- MeSH terms
- Capillary Permeability, Endothelium, Vascular, Humans, Signal Transduction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
