VE-Cadherin and Endothelial Adherens Junctions: Active Guardians of Vascular Integrity
Open accessAbstract
VE-cadherin is a component of endothelial cell-to-cell adherens junctions, and it has a key role in the maintenance of vascular integrity. During embryo development, VE-cadherin is required for the organization of a stable vascular system, and in the adult it controls vascular permeability and inhibits unrestrained vascular growth. The mechanisms of action of VE-cadherin are complex and include reshaping and organization of the endothelial cell cytoskeleton and modulation of gene transcription. Here we review some of the most important pathways through which VE-cadherin modulates vascular homeostasis and discuss the emerging concepts in the overall biological role of this protein.
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PECAM1 and CDH5 levels increased gradually over time in VSAs, reflecting endothelial network development.
“Gene-expression analysis corroborated these morphological observations, showing that PECAM1 and CDH5 levels increased gradually over time, reflecting endothelial network development 24 .”
From Vascularized human skin assembloids model compartmental skin organization and immune responsiveness in vitro (2026) · cites this paper as [24]
The Review’s Figure 2C caption reports that PECAM expression rises and VE-cadherin transcripts appear during embryonic stem-cell differentiation, supporting their connection to endothelial development. It does not report measurements in VSAs or a gradual increase: the caption describes rapid PECAM upregulation, followed by VE-cadherin expression, with transcript levels remaining high and consistent after day 5. No page number is available in our copy. (LLM, conf=0.86)
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- Authors
- Giannotta, M., Trani, M., & Dejana, E.
- Affiliations
- IFOM (IT)
- University of Milan (IT)
- Corresponding author
- Dejana, Elisabetta
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 26
- Issue
- 5
- Pages
- 441-454
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W1993429855
- Cited by
- 854
- References
- 1
- Citations by year
- 2026: 58 · 2025: 73 · 2024: 77 · 2023: 79 · 2022: 85 · 2021: 93 · 2020: 69 · 2019: 65 · 2018: 61 · 2017: 71 · 2016: 40 · 2015: 49 · 2014: 32 · 2013: 1
- FWCI
- 6.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Developmental Cell (publishedVersion)
- PubMed (publishedVersion)
- INFM-OAR (INFN Catania) (submittedVersion, other-oa)
- Funders
- European Commission (241861)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Keywords
- VE-cadherin, adherens junctions, endothelial cells, vascular integrity, vascular permeability, vascular development, cytoskeletal organization, gene transcription, vascular homeostasis, embryonic vascular development
- MeSH terms
- Cadherin 5, Cell Communication, Endothelium, Vascular, Humans, Antigens, CD, Cadherins, Gene Expression Regulation, Developmental, Neovascularization, Physiologic, Focal Adhesions, Endothelial Cells, Embryonic Development, Metabolic Networks and Pathways
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