The low-density lipoprotein receptor-related protein 1 in inflammation
Abstract
Purpose of review The lipoprotein receptor low-density lipoprotein receptor-related protein 1 (LRP1) functions both in endocytosis and in signal transduction. Recently, it has become clear that LRP1 modulates the inflammatory response to various noxious stimuli. This review is to summarize our current knowledge about the role of LRP1 in inflammation. Recent findings LRP1 modulates the inflammatory response in different organs and under various pathophysiological conditions. Both direct regulation of inflammatory signaling through the binding of extracellular messengers or intracellular signaling molecules and indirect modulation through the interaction with other transmembrane receptors or the endocytosis of extracellular factors have been described. Regulation by LRP1 effects cytokine secretion, phagocytosis and migration of cells of the immune system. Summary In recent years, LRP1 emerged as an important regulator of the inflammatory response. Owing to the ubiquitous expression of this receptor, this function is of importance in different organs and under various pathophysiological conditions in which inflammation contributes to disease, that is atherosclerosis, neurodegeneration and organ fibrosis, for example of the lung or liver.
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The impaired interaction of apoE Sendai with LRP1 may have functional consequences involving lesion inflammation.
“As LRP1 is also involved in macrophage infl ammation and signaling ( 16, 52, 53 ), the impaired interaction of apoE Sendai with LRP1 may also have functional consequences involving lesion infl ammation.”
From Macrophage-derived apoESendai suppresses atherosclerosis while causing lipoprotein glomerulopathy in hyperlipidemic mice (2014) · cites this paper as [52]
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Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4
Pålsson‐McDermott, E. M., & O'Neill, L. A. J. (2004) · Immunology · doi:10.1111/j.1365-2567.2004.01976.x · Cited by 1,254 · see citing works
Jaeger, L. B., Dohgu, S., Sultana, R., Lynch, J. L., Owen, J. B., Erickson, M. A., Shah, G. N., Price, T. O., Fleegal-Demotta, M. A., Butterfiled, D. A., et al. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.01.017 · Cited by 281 · see citing works
Macrophage LRP-1 Controls Plaque Cellularity by Regulating Efferocytosis and Akt Activation
Yancey, P. G., Blakemore, J., Ding, L., Fan, D., Overton, C. D., Zhang, Y., Linton, M. F., & Fazio, S. (2010) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.109.202051 · Cited by 168 · see citing works
Zerbinatti, C. V., Wozniak, D. F., Cirrito, J., Cam, J. A., Osaka, H., Bales, K. R., Zhuo, M., Paul, S. M., Holtzman, D. M., & Bu, G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305803101 · Cited by 133 · see citing works
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Allen, S. D., Liu, Y.-G., Kim, T., Bobbala, S., Yi, S., Zhang, X., Choi, J., & Scott, E. A. (2019) · Biomaterials Science · doi:10.1039/c8bm01224e · Cited by 95 · see citing works
Tavori, H., Fan, D., Giunzioni, I., Zhu, L., Linton, M. F., Fogo, A. B., & Fazio, S. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m049874 · Cited by 10 · see citing works
- Authors
- May, P.
- Affiliations
- University of Freiburg (DE)
- Corresponding author
- May, Petra
- Venue
- Current Opinion in Lipidology
- Published
- 2013-04
- Volume
- 24
- Issue
- 2
- Pages
- 134-137
- ISSN
- 0957-9672 (ISSN-L)
- OpenAlex
- W2321224671
- Cited by
- 49
- References
- 4
- Citations by year
- 2026: 2 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 7 · 2020: 3 · 2019: 3 · 2018: 6 · 2017: 9 · 2016: 1 · 2015: 3 · 2014: 5 · 2013: 2
- FWCI
- 3.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Lipidology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Keywords
- LRP1, inflammation, endocytosis, signal transduction, cytokine production, phagocytosis, leukocyte migration, atherosclerosis, neurodegeneration, organ fibrosis, pulmonary fibrosis, liver fibrosis
- MeSH terms
- Animals, Humans, Inflammation, Lipopolysaccharides, Macrophages, Phagocytosis, Receptors, LDL, Tumor Necrosis Factor-alpha, Signal Transduction, NF-kappa B, Apoptosis, Tumor Suppressor Proteins, Low Density Lipoprotein Receptor-Related Protein-1, p38 Mitogen-Activated Protein Kinases, Atherosclerosis, Mice
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