Cited by 95Nanoparticle-Based Drug DeliveryNatural Compounds in Disease TreatmentAtherosclerosis and Cardiovascular Diseases

Celastrol-loaded PEG- b -PPS nanocarriers as an anti-inflammatory treatment for atherosclerosis

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Allen, Sean D., Liu, Yu-Gang, Kim, Taehyeung, Bobbala, Sharan, Yi, Sijia, Zhang, Xiaohan, Choi, Jaehyuk, Scott, Evan A.·2019·Biomaterials Science

Abstract

Encapsulation within poly(ethylene glycol)- b -poly(propylene sulfide) micelles reduces the toxicity of celastrol and enhances its anti-inflammatory effect during treatment of atherosclerosis.

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Crossref · 10.1039/c8bm01224e

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Research works printed but not linked: 7

  1. [1]Rafieian-Kopaei M, Setorki M, Doudi M, Baradaran A and Nasri H, Int J Prev Med, 2014, 5, 927– 946. 25489440 PMC4258672
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  7. [54]Gentle IE, Wong WW, Evans JM, Bankovacki A, Cook WD, Khan NR, Nachbur U, Rickard J, Anderton H, Moulin M, Lluis JM, Moujalled DM, Silke J and Vaux DL, The Journal of biological chemistry, 2016, 291, 2547. 26826208 PMC4732234

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Authors
Allen, S. D., Liu, Y.-G., Kim, T., Bobbala, S., Yi, S., Zhang, X., Choi, J., & Scott, E. A.
Affiliations
  • Northwestern University (US)
  • Department of Biomedical Engineering
Corresponding author
Scott, Evan A.
Venue
Biomaterials Science
Published
2019
Volume
7
Issue
2
Pages
657-668
ISSN
  • 2047-4830 (ISSN-L)
  • 2047-4849
OpenAlex
W2903727712
Cited by
95
References
64
Citations by year
2026: 7 · 2025: 18 · 2024: 5 · 2023: 7 · 2022: 19 · 2021: 14 · 2020: 18 · 2019: 7
FWCI
3.15
Type
journal article
Language
en
Open access
Locations
  • Biomaterials Science (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Division of Chemical, Bioengineering, Environmental, and Transport Systems (1453576)
  • NIH Office of the Director (1DP2HL132390-01)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
  • Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Keywords
celastrol, nanocarriers, drug delivery, NF-κB inhibition, atherosclerosis, anti-inflammatory therapy, TNF-α, lipopolysaccharide-induced inflammation, RAW 264.7 macrophages, atherosclerotic plaque, Ldlr-/- mice, neutrophils, inflammatory monocytes, cytotoxicity reduction
MeSH terms
RAW 264.7 Cells, Animals, Anti-Inflammatory Agents, Non-Steroidal, Drug Carriers, Female, Mice, Inbred C57BL, Micelles, Polyethylene Glycols, Sulfides, Triterpenes, Signal Transduction, NF-kappa B, Mice, Pentacyclic Triterpenes, Plaque, Atherosclerotic

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