Celastrol-loaded PEG- b -PPS nanocarriers as an anti-inflammatory treatment for atherosclerosis
Open accessAbstract
Encapsulation within poly(ethylene glycol)- b -poly(propylene sulfide) micelles reduces the toxicity of celastrol and enhances its anti-inflammatory effect during treatment of atherosclerosis.
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Flagged first, then by citations
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Cited by
Sorted by citations
Stack, T., Vincent, M., Vahabikashi, A., Li, G., Perkumas, K. M., Stamer, W. D., Johnson, M., & Scott, E. (2020) · Small · doi:10.1002/smll.202004205 · Cited by 37 · see citing works
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“Gaining prominence for its anti-inflammatory and antioxidant properties [22, 23], celastrol has recently emerged as a potential therapeutic agent in cancer treat-ment.”
Background
- Authors
- Allen, S. D., Liu, Y.-G., Kim, T., Bobbala, S., Yi, S., Zhang, X., Choi, J., & Scott, E. A.
- Affiliations
- Northwestern University (US)
- Department of Biomedical Engineering
- Corresponding author
- Scott, Evan A.
- ORCID
- Venue
- Biomaterials Science
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2019
- Volume
- 7
- Issue
- 2
- Pages
- 657-668
- ISSN
- 2047-4830 (ISSN-L)
- 2047-4849
- PMC
- PMC6368678
- OpenAlex
- W2903727712
- Cited by
- 95
- References
- 64
- Citations by year
- 2026: 7 · 2025: 18 · 2024: 5 · 2023: 7 · 2022: 19 · 2021: 14 · 2020: 18 · 2019: 7
- FWCI
- 3.15
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biomaterials Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Division of Chemical, Bioengineering, Environmental, and Transport Systems (1453576)
- NIH Office of the Director (1DP2HL132390-01)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- celastrol, nanocarriers, drug delivery, NF-κB inhibition, atherosclerosis, anti-inflammatory therapy, TNF-α, lipopolysaccharide-induced inflammation, RAW 264.7 macrophages, atherosclerotic plaque, Ldlr-/- mice, neutrophils, inflammatory monocytes, cytotoxicity reduction
- MeSH terms
- RAW 264.7 Cells, Animals, Anti-Inflammatory Agents, Non-Steroidal, Drug Carriers, Female, Mice, Inbred C57BL, Micelles, Polyethylene Glycols, Sulfides, Triterpenes, Signal Transduction, NF-kappa B, Mice, Pentacyclic Triterpenes, Plaque, Atherosclerotic
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