The Basic Helix-Loop-Helix Transcription Factor E47 Reprograms Human Pancreatic Cancer Cells to a Quiescent Acinar State With Reduced Tumorigenic Potential

Kim, SangWun; Lahmy, Reyhaneh; Riha, Chelsea; Yang, Challeng; Jakubison, Brad L.; van Niekerk, Jaco; Staub, Claudio; Wu, Yifan; Gates, Keith; Dong, Duc Si; Konieczny, Stephen F.; Itkin-Ansari, Pamela

doi:10.1097/mpa.0000000000000328

The Basic Helix-Loop-Helix Transcription Factor E47 Reprograms Human Pancreatic Cancer Cells to a Quiescent Acinar State With Reduced Tumorigenic Potential

Objectives Pancreatic ductal adenocarcinoma (PDA) initiates from quiescent acinar cells that attain a Kras mutation, lose signaling from basic helix-loop-helix (bHLH) transcription factors, undergo acinar-ductal metaplasia, and rapidly acquire increased growth potential. We queried whether PDA ce…