The DOI matches its Crossref record; 114 of the 114 references it cites were found in a registry or an index.
Acinar cell plasticity and development of pancreatic ductal adenocarcinoma
Open accessAbstract
Acinar cells in the adult pancreas show high plasticity and can undergo transdifferentiation to a progenitor-like cell type with ductal characteristics. This process, termed acinar-to-ductal metaplasia (ADM), is an important feature facilitating pancreas regeneration after injury. Data from animal models show that cells that undergo ADM in response to oncogenic signalling are precursors for pancreatic intraepithelial neoplasia lesions, which can further progress to pancreatic ductal adenocarcinoma (PDAC). As human pancreatic adenocarcinoma is often diagnosed at a stage of metastatic disease, understanding the processes that lead to its initiation is important for the discovery of markers for early detection, as well as options that enable an early intervention. Here, the critical determinants of acinar cell plasticity are discussed, in addition to the intracellular and extracellular signalling events that drive acinar cell metaplasia and their contribution to development of PDAC.
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Slow TCA flux and ATP production in primary solid tumours but not metastases
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Single-nucleus and in situ RNA-sequencing reveal cell topographies in the human pancreas
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Metadata
- Authors
- Storz, P.
- Venue
- Nature Reviews Gastroenterology & Hepatology
- Published
- 2017-03-08
- Volume
- 14
- Issue
- 5
- Pages
- 296-304
- ISSN
- 1759-5045 (ISSN-L)
- 1759-5053
- OpenAlex
- W2593410994
- Cited by
- 389
- References
- 114
- FWCI
- 2.80
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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