Standard Operating Procedures for Biospecimen Collection, Processing, and Storage: From the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer
Open accessAbstract
High-quality and well-annotated biorepositories are needed to better understand the pathophysiology and biologic mechanisms of chronic pancreatitis (CP) and its consequences. We report a methodology for the development of a robust standard operating procedure (SOP) for a biorepository based on the experience of the clinical centers within the consortium to study Chronic Pancreatitis, Diabetes and Pancreas Cancer Clinical Centers (CPDPC), supported by the National Cancer Institute and the National Institute for Diabetes and Digestive and Kidney Diseases as a unique multidisciplinary model to study CP, diabetes, and pancreatic cancer in both children and adults. Standard operating procedures from the CPDPC centers were evaluated and consolidated. The literature was reviewed for standard biorepository operating procedures that facilitated downstream molecular analysis. The existing literature on biobanking practices was harmonized with the SOPs from the clinical centers to produce a biorepository for pancreatic research. This article reports the methods and basic principles behind the creation of SOPs to develop a biorepository for the CPDPC. These will serve as a guide for investigators developing biorepositories in pancreas research. Rigorous and meticulous adherence to standardized biospecimen collection will facilitate investigations to better understand the pathophysiology and biologic mechanisms of CP, diabetes, and pancreatic cancer.
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Vitonis, A. F., Vincent, K., Rahmioglu, N., Fassbender, A., Buck Louis, G. M., Hummelshoj, L., Giudice, L. C., Stratton, P., Adamson, G. D., Becker, C. M., et al. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.07.1244 · Cited by 236 · see citing works
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Self-citationLiu, Y., Kaur, S., Huang, Y., Fahrmann, J. F., Rinaudo, J. A., Hanash, S. M., Batra, S. K., Singhi, A. D., Brand, R. E., Maitra, A., et al. (2020) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.epi-20-0161 · Cited by 17 · see citing works
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- Authors
- Fisher, W. E., Cruz-Monserrate, Z., McElhany, A. L., Lesinski, G. B., Hart, P. A., Ghosh, R., Van Buren, G., Fishman, D. S., Rinaudo, J. A. S., Serrano, J., Srivastava, S., Mace, T., Topazian, M., Feng, Z., Yadav, D., Pandol, S. J., Hughes, S. J., Liu, R. Y., Lu, E., Orr, R., Whitcomb, D. C., Abouhamze, A. S., Steen, H., Sellers, Z. M., Troendle, D. M., Uc, A., Lowe, M. E., & Conwell, D. L.
- Affiliations
- Baylor College of Medicine (US)
- Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, and Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, OH;
- Emory University (US)
- The Ohio State University Wexner Medical Center (US)
- The University of Texas MD Anderson Cancer Center (US)
- The Elkins Pancreas Center, Michael E. DeBakey Department of Surgery, and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX;
- National Cancer Institute (US)
- Division of Digestive Diseases and Nutrition, National Institutes of Diabetes and Digestive and Kidney Diseases, Bethesda, MD;
- Mayo Clinic (US)
- University of Pittsburgh (US)
- Cedars-Sinai Medical Center (US)
- University of Florida Health (US)
- Indiana Clinical and Translational Sciences Institute (US)
- University of Florida (US)
- Boston Children's Hospital (US)
- Lucile Packard Children's Hospital (US)
- The University of Texas Southwestern Medical Center (US)
- Stead Family Department of Pediatrics, University of Iowa, Stead Family Children's Hospital, Iowa City, IA; and
- Washington University in St. Louis (US)
- Corresponding author
- Fisher, William E.
- McElhany, Amy L.
- Topazian, Mark
- Whitcomb, David C.
- Steen, Hanno
- ORCID
- Venue
- Pancreas
- Published
- 2018-11
- Volume
- 47
- Issue
- 10
- Pages
- 1213-1221
- ISSN
- 0885-3177 (ISSN-L)
- 1536-4828
- PMC
- PMC6197069
- OpenAlex
- W2896422686
- Cited by
- 34
- References
- 1
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 3 · 2023: 4 · 2022: 6 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 1
- FWCI
- 3.12
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Pancreas (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (P50AA011999)
- National Institute of Diabetes and Digestive and Kidney Diseases (U01DK108327, U01DK108326, U01DK108320, U01DK108300, U01DK108306, U01DK108323, U01DK108314, U01DK108328, U01DK108334, P30DK054759, U01DK108288, P01DK098108)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
- Keywords
- standard operating procedures, biospecimen collection, biospecimen storage, biorepository, chronic pancreatitis, diabetes mellitus, pancreatic cancer, biobanking, data harmonization
- MeSH terms
- Child, Diabetes Mellitus, Humans, Pancreatic Neoplasms, Preservation, Biological, Specimen Handling, Guidelines as Topic, Biological Specimen Banks, Biomedical Research, Pancreatitis, Chronic
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