Optimal Timing of Oral Refeeding in Mild Acute Pancreatitis: Results of an Open Randomized Multicenter Trial
Abstract
Objectives The aim of this study was to compare 2 protocols regarding the initiation of oral nutrition in patients with mild acute pancreatitis. Methods We randomized 143 patients to the Lipase directed (LIP) (n = 74) and the self selected PAT (n = 69) group. In the (PAT) group, the patients restarted eating through self-selection. In the LIP group, serum lipase had to normalize before eating. Results The mean time between admission and oral nutrition was 2 days (interquartile range [IQR], 1-3) in the PAT group and 3 days (IQR, 2-4) in the LIP group (P Conclusions We were not able to demonstrate a difference in postprandial abdominal pain or in the length of hospital stay. Patients with self-selected eating, however, were able to restart eating 1 day earlier, and this difference was found to be significant. Our data suggest that normalization of serum lipase is not obligatory for enteral nutrition in mild acute pancreatitis.
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Starting early feeding with clear liquids, soft diet, low-fat diet, or solid food was shown to be safe in different RCTs.
“Starting early feeding with clear liquids, soft diet, low-fat diet,”
From ESPEN guideline on hospital nutrition (2021) · cites this paper as [195]
Cites
Practice guidelines in acute pancreatitis
Banks, P. A., Freeman, M. L., & the Practice Parameters Committee of the American College of Gastroenterology (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00856.x · Cited by 2,050 · see citing works
Alcohol Consumption, Cigarette Smoking, and the Risk of Recurrent Acute and Chronic Pancreatitis
Yadav, D. (2009) · Archives of Internal Medicine · doi:10.1001/archinternmed.2009.125 · Cited by 466 · see citing works
Eckerwall, G. E., Tingstedt, B. B. Å., Bergenzaun, P. E., & Andersson, R. G. (2007) · Clinical Nutrition · doi:10.1016/j.clnu.2007.04.007 · Cited by 227 · see citing works
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ESPEN guideline on hospital nutrition
Thibault, R., Abbasoglu, O., Ioannou, E., Meija, L., Ottens-Oussoren, K., Pichard, C., Rothenberg, E., Rubin, D., Siljamäki-Ojansuu, U., Vaillant, M.-F., et al. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.09.039 · Cited by 259 · see citing works
- Authors
- Teich, N., Aghdassi, A., Fischer, J., Walz, B., Caca, K., Wallochny, T., von Aretin, A., von Boyen, G., Göpel, S., Ockenga, J., Leodolter, A., Rüddel, J., Weber, E., Mayerle, J., Lerch, M. M., Mössner, J., & Schiefke, I.
- Affiliations
- Klinikum St. Georg (DE)
- Universität Greifswald (DE)
- University Hospital Leipzig (DE)
- Klinikum Ludwigsburg (DE)
- St. Elisabeth-Krankenhaus Leipzig (DE)
- Universitätsklinikum Tübingen (DE)
- Corresponding author
- Teich, Niels
- ORCID
- Venue
- Pancreas
- Published
- 2010-10
- Volume
- 39
- Issue
- 7
- Pages
- 1088-1092
- ISSN
- 0885-3177 (ISSN-L)
- OpenAlex
- W2020197652
- Cited by
- 94
- References
- 3
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 7 · 2023: 6 · 2022: 5 · 2021: 6 · 2020: 7 · 2019: 6 · 2018: 6 · 2017: 8 · 2016: 5 · 2015: 13 · 2014: 5 · 2013: 5 · 2012: 6
- FWCI
- 4.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pancreas (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Gallbladder and Bile Duct Disorders
- Keywords
- mild acute pancreatitis, oral refeeding, enteral nutrition, postprandial abdominal pain, length of hospital stay
- MeSH terms
- Acute Disease, Adult, C-Reactive Protein, Eating, Female, Humans, Length of Stay, Lipase, Male, Middle Aged, Pain Measurement, Pancreatitis, Smoking, Time Factors
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