Immediate oral feeding in patients with mild acute pancreatitis is safe and may accelerate recovery—A randomized clinical study
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Background & aims In acute pancreatitis, traditional treatment has been initial fasting on purpose to avoid activation of proteolytic enzymes and pancreatic enzyme secretion. The aim of the present study was to evaluate the efficacy and feasibility of immediate oral feeding as compared to traditional fasting in patients with mild acute pancreatitis. Methods Sixty patients were randomized to the two treatment groups, fasting or immediate oral feeding. The inclusion criteria were pancreas amylase > or =3 times above normal, onset of abdominal pain within 48 h, acute physiological and chronic health evaluation (APACHE) score Results The groups were comparable with respect to age, sex, etiology, APACHE, time from onset of pain and amylase at admission. No significant differences were seen between the groups concerning levels of amylase, CRP, leukocytes, abdominal pain or number of gastrointestinal symptoms. The LOHS was significantly shorter in the oral feeding group (4 vs. 6 days; p Conclusions No signs of exacerbation of the disease process were seen in terms of significant differences between treatment groups for amylase or systemic inflammatory response. In mild acute pancreatitis, immediate oral feeding was feasible and safe and may accelerate recovery without adverse gastrointestinal events.
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Starting early feeding with clear liquids, soft diet, low-fat diet, or solid food was shown to be safe in different RCTs.
“Starting early feeding with clear liquids, soft diet, low-fat diet,”
From ESPEN guideline on hospital nutrition (2021) · cites this paper as [196]
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- Authors
- Eckerwall, G. E., Tingstedt, B. B. Å., Bergenzaun, P. E., & Andersson, R. G.
- Affiliations
- Skåne University Hospital (SE)
- Corresponding author
- Andersson, Roland G.
- Venue
- Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2007-12
- Volume
- 26
- Issue
- 6
- Pages
- 758-763
- ISSN
- 0261-5614 (ISSN-L)
- OpenAlex
- W1964043765
- Cited by
- 227
- References
- 27
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 11 · 2023: 11 · 2022: 12 · 2021: 17 · 2020: 10 · 2019: 17 · 2018: 18 · 2017: 18 · 2016: 10 · 2015: 25 · 2014: 11 · 2013: 16 · 2012: 10
- FWCI
- 6.91
- Type
- journal article
- Language
- en
- Open access
- green
- lup.lub.lu.se
- Licence
- Locations
- Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Gallbladder and Bile Duct Disorders
- Keywords
- mild acute pancreatitis, fasting, length of hospital stay, pancreatic amylase, systemic inflammatory response, C-reactive protein, recovery, gastrointestinal tolerance
- MeSH terms
- Adult, Aged, Amylases, C-Reactive Protein, Enteral Nutrition, Fasting, Female, Humans, Inflammation, Length of Stay, Leukocytes, Male, Middle Aged, Pancreas, Pancreatitis, Prospective Studies, Abdominal Pain, Treatment Outcome, APACHE
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