Anemia in Pediatric Celiac Disease: Association With Clinical and Histological Features and Response to Gluten‐free Diet
Abstract
Goals The aim of the present study was to compare clinical, serological, and histological manifestations between children with anemia and without anemia at celiac disease (CD) diagnosis. Background Despite being a common finding, the association between the presence of anemia and clinicohistopathological presentation of CD in children remains obscure. Study A total of 455 patients with CD Results Anemia was detected in 18.0% of the patients. Children with anemia had higher values for transglutaminase 2 antibodies (120.0 U/L vs 88.0 U/L, P Conclusions Anemia at CD diagnosis is associated with more severe histological and serological presentation in children. Furthermore, low hemoglobin may not fully recover even after a median of 1 year on a strict GFD.
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Poor compliance to the gluten-free diet may hamper recovery from anaemia.
“Poor compliance to GFD may hamper recovery (70, 73).”
From ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease. (2022) · cites this paper as [70]
Anaemia is a frequent finding (12-24%) in children with untreated celiac disease.
“Anaemia is a frequent finding (12-24%) in children with untreated CD (64, 67-70).”
From ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease. (2022) · cites this paper as [70]
In most cases (84%-96%) anaemia improves or recovers on a gluten-free diet.
“In most cases (84%-96%) anaemia improves or recovers on a GFD (14, 64, 67, 70, 72).”
From ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease. (2022) · cites this paper as [70]
Cites
Przybyszewska, J., & Żekanowska, E. (2014) · Gastroenterology Review · doi:10.5114/pg.2014.45102 · Cited by 70 · see citing works
ÇATAL, F., TOPAL, E., ERMİŞTEKIN, H., YILDIRIM ACAR, N., SİNANOĞLU, M. S., KARABİBER, H., & SELİMOĞLU, M. A. (2015) · TURKISH JOURNAL OF MEDICAL SCIENCES · doi:10.3906/sag-1402-169 · Cited by 16 · see citing works
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ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease.
Mearin, M. L., Agardh, D., Antunes, H., Al‐toma, A., Auricchio, R., Castillejo, G., Catassi, C., Ciacci, C., Discepolo, V., Dolinsek, J., et al. (2022) · Journal of pediatric gastroenterology and nutrition · doi:10.1097/mpg.0000000000003540 · Cited by 186 · see citing works
Self-citationNestares, T., Martín-Masot, R., Labella, A., Aparicio, V. A., Flor-Alemany, M., López-Frías, M., & Maldonado, J. (2020) · Nutrients · doi:10.3390/nu12030844 · Cited by 41 · see citing works
- Authors
- Rajalahti, T., Repo, M., Kivelä, L., Huhtala, H., Mäki, M., Kaukinen, K., Lindfors, K., & Kurppa, K.
- Affiliations
- Tampere University Hospital (FI)
- University of Tampere (FI)
- Corresponding author
- Rajalahti, Teemu
- Repo, Marleena
- Kivelä, Laura
- Mäki, Markku
- Kaukinen, Katri
- Lindfors, Katri
- Kurppa, Kalle
- ORCID
- Venue
- Journal of Pediatric Gastroenterology and Nutrition
- Publisher
- Wiley
- Published
- 2017-01
- Volume
- 64
- Issue
- 1
- Pages
- e1-e6
- ISSN
- 0277-2116 (ISSN-L)
- 1536-4801
- OpenAlex
- W2338099330
- Cited by
- 51
- References
- 2
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 6 · 2023: 3 · 2022: 3 · 2021: 10 · 2020: 8 · 2019: 5 · 2018: 3 · 2017: 5
- FWCI
- 4.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pediatric Gastroenterology and Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Office of Naval Research
- National Science Foundation
- Topics
- Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
- Health Sciences › Medicine › Surgery › Eosinophilic Esophagitis
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Wheat and Barley Genetics and Pathology
- Keywords
- celiac disease, anemia, pediatric celiac disease, gluten-free diet, dietary adherence, iron deficiency, hemoglobin, serological response, histological damage
- MeSH terms
- Protein Glutamine gamma Glutamyltransferase 2, Adolescent, Anemia, Antibodies, Celiac Disease, Child, Female, Hemoglobins, Humans, Intestine, Small, Male, Patient Compliance, Transglutaminases, GTP-Binding Proteins, Diet, Gluten-Free
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