The hematologic manifestations of pediatric celiac disease at the time ofdiagnosis and efficiency of gluten-free diet
Abstract
Background/aim To determine the hematologic manifestations at the time of diagnosis of celiac disease in children and the effects of a gluten-free diet on hematologic signs upon follow-up. Materials and methods The records ofpatients with celiac disease who received a follow up examination at the Pediatric Gastroenterology Clinic between June 2006 and June 2013 were retrospectively examined. Results Ninety-one patients were included in the study. The mean age at diagnosis was 8.1 ± 4.21 years and 59 patients (64.8%) were female. Thirty-two patients (35.2%) had hematologic signs at the time of diagnosis. Anemia (24.2%) was the most common hematologic sign, followed by thrombocytosis (16.5%) and leukopenia (4.4%). The tTG IgA titers were screened in 80 of the 91 patients during diagnosis. Follow-up examinations found that remission for anemia (P = 0.0 17), thrombocytosis (P = 0.039), and decreases in tTG IgA titers (P = 0.034) were more prominent in patients who had followed a strict gluten-free diet. Conclusion Approximately one-third of the celiac disease patients had hematologic manifestations at the time of diagnosis. Remission in hematologic signs and decrease in tTG IgA titers were more prominent in patients who had adhered to a gluten-free diet.
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Anaemia is a frequent finding (12-24%) in children with untreated celiac disease.
“Anaemia is a frequent finding (12-24%) in children with untreated CD (64, 67-70).”
From ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease. (2022) · cites this paper as [68]
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- Authors
- ÇATAL, F., TOPAL, E., ERMİŞTEKIN, H., YILDIRIM ACAR, N., SİNANOĞLU, M. S., KARABİBER, H., & SELİMOĞLU, M. A.
- ORCID
- TOPAL, Erdem
- Venue
- TURKISH JOURNAL OF MEDICAL SCIENCES
- Published
- 2015
- Volume
- 45
- Issue
- 3
- Pages
- 663-667
- ISSN
- 1300-0144 (ISSN-L)
- 1303-6165
- OpenAlex
- W2121376864
- Cited by
- 16
- References
- 30
- Citations by year
- 2026: 2 · 2024: 3 · 2023: 1 · 2022: 2 · 2020: 3 · 2019: 1 · 2018: 1 · 2016: 2 · 2015: 1
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- TURKISH JOURNAL OF MEDICAL SCIENCES (publishedVersion)
- PubMed (publishedVersion)
- DergiPark (Istanbul University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
- Health Sciences › Medicine › Surgery › Eosinophilic Esophagitis
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Wheat and Barley Genetics and Pathology
- Keywords
- pediatric celiac disease, hematologic manifestations, anemia, thrombocytosis, leukopenia, gluten-free diet, tTG-IgA, remission, dietary adherence
- MeSH terms
- Anemia, Celiac Disease, Child, Female, Follow-Up Studies, Humans, Leukopenia, Male, Retrospective Studies, Thrombocytosis, Treatment Outcome, Diet, Gluten-Free
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