Serum immunoglobulin A levels do not correlate with liver disease severity in pediatric nonalcoholic fatty liver disease
Open accessAbstract
Serum immunoglobulin A (IgA) is a biomarker of liver disease severity in adult nonalcoholic fatty liver disease (NAFLD). The objective of this study was to assess whether this is true in pediatric NAFLD. This was a retrospective study of children followed in the Steatohepatitis Center of a tertiary care center (2010–2017). Serum IgA levels, histology and biochemical markers of hepatocellular injury and metabolic dysregulation were collected. Of the 600 children with available serum IgA levels (mean age 14 ± 3 years, 62% boys, 80% non‐Hispanic), IgA was elevated in 4%. The group with elevated IgA levels was younger and had a greater representation of Hispanic ethnicity compared with those with normal or low IgA. Body mass index and aminotransferases were not different between the groups. Histology was available for 170 children and was not different in those with elevated, normal and low IgA. In contrast to adults, serum IgA is not a biomarker of liver disease severity in pediatric NAFLD.
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Serum IgA is elevated in patients with NAFLD and is an independent predictor of advanced fibrosis.
“Serum IgA, secreted by plasma cells in secondary lymphoid organs, has been shown to be elevated in patients with NAFLD,22,23 and was an independent predictor of advanced fibrosis.22”
From Intestinal B cells license metabolic T-cell activation in NASH microbiota/antigen-independently and contribute to fibrosis by IgA-FcR signalling (2023) · cites this paper as [23]
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- Authors
- Mouzaki, M., Bramlage, K., Arce‐Clachar, A. C., & Xanthakos, S. A.
- Affiliations
- Cincinnati Children's Hospital Medical Center (US)
- Corresponding author
- Mouzaki, Marialena
- Venue
- Journal of Pediatric Gastroenterology and Nutrition
- Publisher
- Wiley
- Published
- 2018-11
- Volume
- 67
- Issue
- 5
- Pages
- 631-634
- ISSN
- 0277-2116 (ISSN-L)
- 1536-4801
- PMC
- PMC6447283
- OpenAlex
- W2884343088
- Cited by
- 6
- References
- 19
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 1 · 2020: 1
- FWCI
- 0.19
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Pediatric Gastroenterology and Nutrition (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (T32DK007727)
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Surgery › Pediatric Hepatobiliary Diseases and Treatments
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Keywords
- serum IgA, pediatric nonalcoholic fatty liver disease, liver disease severity, biomarkers, hepatic steatohepatitis, transaminases, body mass index, Hispanic origin, liver histopathology
- MeSH terms
- Adolescent, Child, Female, Humans, Immunoglobulin A, Male, Retrospective Studies, Severity of Illness Index, Biomarkers, Non-alcoholic Fatty Liver Disease
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