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Cited by 304

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Celiac Disease Revealed in 3% of Swedish 12‐year‐olds Born During an Epidemic

Myléus, Anna, Ivarsson, Anneli, Webb, Charlotta, Danielsson, Lars, Hernell, Olle, Högberg, Lotta, Karlsson, Eva, Lagerqvist, Carina, Norström, Fredrik, Rosén, Anna, Sandström, Olof, Stenhammar, Lars, Stenlund, Hans, Wall, Stig, Carlsson, Annelie·2009·Journal of Pediatric Gastroenterology and Nutrition

Abstract

Objective: Sweden experienced a marked epidemic of celiac disease between 1984 and 1996 in children younger than 2 years of age, partly explained by changes in infant feeding. The objective of this study was to determine the prevalence of celiac disease in 12‐year‐olds born during the epidemic (1993), including both symptomatic and screening detected cases. Patients and Methods: All sixth‐grade children in participating schools were invited (n = 10,041). Symptomatic and, therefore, previously diagnosed celiac disease cases were ascertained through the National Swedish Childhood Celiac Disease Register and/or medical records. All serum samples were analyzed for antihuman tissue transglutaminase (tTG)‐IgA (Celikey), and serum‐IgA, and some for tTG‐IgG and endomysial antibodies. A small intestinal biopsy was recommended for all children with suspected undiagnosed celiac disease. Results: Participation was accepted by 7567 families (75%). Previously diagnosed celiac disease was found in 67 children; 8.9/1000 (95% confidence interval [CI] 6.7–11). In another 192 children, a small intestinal biopsy was recommended and was performed in 180. Celiac disease was verified in 145 children, 20/1000 (95% CI 17–23). The total prevalence was 29/1000 (95% CI 25–33). Conclusions: The celiac disease prevalence of 29/1000 (3%)—with two thirds of cases undiagnosed before screening—is 3‐fold higher than the usually suggested prevalence of 1%. When these 12‐year‐olds were infants, the prevailing feeding practice was to introduce gluten abruptly, often without ongoing breast‐feeding, which might have contributed to this unexpectedly high prevalence.

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Metadata

Authors
Myléus, A., Ivarsson, A., Webb, C., Danielsson, L., Hernell, O., Högberg, L., Karlsson, E., Lagerqvist, C., Norström, F., Rosén, A., Sandström, O., Stenhammar, L., Stenlund, H., Wall, S., & Carlsson, A.
Venue
Journal of Pediatric Gastroenterology and Nutrition
Publisher
Wiley
Published
2009-08
Volume
49
Issue
2
Pages
170-176
ISSN
  • 0277-2116 (ISSN-L)
  • 1536-4801
OpenAlex
W2156469479
Cited by
304
References
30
FWCI
20.37
Type
journal article
Language
en
Open access
closed

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Myléus, A., Ivarsson, A., Webb, C., Danielsson, L., Hernell, O., Högberg, L., Karlsson, E., Lagerqvist, C., Norström, F., Rosén, A., Sandström, O., Stenhammar, L., Stenlund, H., Wall, S., & Carlsson, A. (2009). Celiac Disease Revealed in 3% of Swedish 12‐year‐olds Born During an Epidemic. Journal of Pediatric Gastroenterology and Nutrition. https://doi.org/10.1097/mpg.0b013e31818c52cc

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