The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
The Blood-Brain Barrier in Cortical Multiple Sclerosis Lesions
Abstract
The blood-brain barrier (BBB) is composed mainly of specialized endothelial cells characterized by the presence of intercellular tight junctions. Additionally, perivascular cells, astrocytes, and surrounding basement membranes determine BBB integrity. BBB disruption is an early phenomenon in the formation of new white matter multiple sclerosis (MS) lesions; however, knowledge of the extent of BBB changes in gray matter MS lesions is lacking. Here, we studied several markers for BBB integrity in well-characterized brain tissue of patients with MS. Plasma protein leakage was enhanced in white matter lesions compared with that in normal-appearing white matter, whereas plasma protein leakage was absent in gray matter lesions. White matter lesions showed irregular basement membranes and parenchymal depositions of collagen type IV, whereas purely gray matter lesions lacked basement membrane alterations. Similarly, we observed no evidence for astrogliosis and tight junction changes in cortical MS lesions. Although BBB dysfunction is a common feature of white matter MS lesions, cortical MS lesions lack markers for BBB disruption or astrogliosis. Our data may indicate that BBB breakdown is not a critical event in the formation of gray matter MS lesions.
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“This may well reflect the greater microglia and astrocyte activity in the white matter; pure cortical lesions in post-mortem tissues show little or no inflammation (Bo et al., 2004; Brink et al., 2005; van Horssen et al., 2007), although early lesions have been associated with prominent microglial activation (Lucchinetti et al., 2011).”
From A quantitative neuropathological assessment of translocator protein expression in multiple sclerosis (2019) · cites this paper as van Horssen et al., 2007
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“This may well reflect the greater microglia and astrocyte activity in the white matter; pure cortical lesions in post-mortem tissues show little or no inflammation (Bo et al., 2004; Brink et al., 2005; van Horssen et al., 2007), although early lesions have been associated with prominent microglial activation (Lucchinetti et al., 2011).”
From A quantitative neuropathological assessment of translocator protein expression in multiple sclerosis (2019) · cites this paper as van Horssen et al., 2007
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Axonal transection in the lesions of multiple sclerosis
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Self-citationThe blood–brain barrier: an overview
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Cortical demyelination and diffuse white matter injury in multiple sclerosis
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Peterson, J. W., Bö, L., Mörk, S., Chang, A., & Trapp, B. D. (2001) · Annals of Neurology · doi:10.1002/ana.1123 · Cited by 1,403 · cited 1×
“All purely cortical lesions extended inward from the surface of the brain (Type III) (26).”
BackgroundSelf-citationRelapsing and remitting multiple sclerosis: Pathology of the newly forming lesion
Barnett, M. H., & Prineas, J. W. (2004) · Annals of Neurology · doi:10.1002/ana.20016 · Cited by 1,184
Subpial Demyelination in the Cerebral Cortex of Multiple Sclerosis Patients
Bø, L., Vedeler, C. A., Nyland, H. I., Trapp, B. D., & Mørk, S. J. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.7.723 · Cited by 757
Self-citationKERMODE, A. G., THOMPSON, A. J., TOFTS, P., MACMANUS, D. G., KENDALL, B. E., KINGSLEY, D. P. E., MOSELEY, I. F., RUDGE, P., & MCDONALD, W. I. (1990) · Brain · doi:10.1093/brain/113.5.1477 · Cited by 578
Intracortical multiple sclerosis lesions are not associated with increased lymphocyte infiltration
Bø, L., Vedeler, C. A., Nyland, H., Trapp, B. D., & Mørk, S. J. (2003) · Multiple Sclerosis Journal · doi:10.1191/1352458503ms917oa · Cited by 478
Self-citationThe Blood-Brain Barrier in Neuroinflammatory Diseases
de Vries, H. E., Kuiper, J., de Boer, A. G., van Berkel, T. J. C., & Breimer, D. D. (1997) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01320-6 · Cited by 430
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- 10.1093/brain/113.5.1477 · DOI · Paper page
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Brain Endothelial Cell-Cell Junctions: How to “Open” the Blood Brain Barrier
Stamatovic, S. M., Keep, R. F., & Andjelkovic, A. V. (2008) · Current Neuropharmacology · doi:10.2174/157015908785777210 · Cited by 541
Grey matter pathology in multiple sclerosis
Geurts, J. J. G., & Barkhof, F. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70191-1 · Cited by 535
Association between pathological and MRI findings in multiple sclerosis
Filippi, M., Rocca, M. A., Barkhof, F., Brück, W., Chen, J. T., Comı, G., DeLuca, G. C., Stefano, N. D., Erickson, B. J., Evangelou, N., et al. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70003-0 · Cited by 499
Lochhead, J. J., Yang, J., Ronaldson, P. T., & Davis, T. P. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00914 · Cited by 445
Exploring the origins of grey matter damage in multiple sclerosis
Calabrese, M., Magliozzi, R., Ciccarelli, O., Geurts, J. J. G., Reynolds, R., & Martin, R. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3900 · Cited by 414
Metadata
- Authors
- van Horssen, J., Brink, B. P., de Vries, H. E., van der Valk, P., & Bø, L.
- Affiliations
- Vrije Universiteit Amsterdam (NL)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Haukeland University Hospital (NO)
- Corresponding author
- van Horssen, Jack
- Venue
- Journal of Neuropathology & Experimental Neurology
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-04
- Volume
- 66
- Issue
- 4
- Pages
- 321-328
- ISSN
- 0022-3069 (ISSN-L)
- 1554-6578
- OpenAlex
- W1968478844
- Cited by
- 187
- References
- 31
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 8 · 2023: 8 · 2022: 8 · 2021: 5 · 2020: 9 · 2019: 7 · 2018: 8 · 2017: 16 · 2016: 7 · 2015: 11 · 2014: 12 · 2013: 12 · 2012: 18
- FWCI
- 7.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuropathology & Experimental Neurology (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Clinical Neurology › Cerebrovascular and genetic disorders
- Keywords
- blood-brain barrier, multiple sclerosis, gray matter lesions, white matter lesions, plasma protein leakage, basement membrane, type IV collagen, astrocyte activation, tight junctions, endothelial cells, cortical lesions
- MeSH terms
- Adult, Aged, Basement Membrane, Blood-Brain Barrier, Cerebral Cortex, Female, Fibrinogen, Glial Fibrillary Acidic Protein, Humans, Immunoglobulin G, Immunohistochemistry, Male, Membrane Proteins, Middle Aged, Multiple Sclerosis, Tight Junctions, Collagen Type V, Claudin-5
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