de Vries, Helga E.

Overcoming the blood–brain tumor barrier for effective glioblastoma treatment

van Tellingen, O., Yetkin-Arik, B., de Gooijer, M. C., Wesseling, P., Wurdinger, T., & de Vries, H. E. (2015) · Drug Resistance Updates

Barrier Structure and Function StudiesGlioma Diagnosis and Treatment

Cited by 1,035

The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence

Alvarez, J. I., Dodelet-Devillers, A., Kebir, H., Ifergan, I., Fabre, P. J., Terouz, S., Sabbagh, M., Wosik, K., Bourbonnière, L., Bernard, M., et al. (2011) · Science

Barrier Structure and Function StudiesHedgehog Signaling Pathway Studies

Cited by 845

Blood–brain barrier alterations in both focal and diffuse abnormalities on postmortem MRI in multiple sclerosis

Vos, C. M. P., Geurts, J. J. G., Montagne, L., van Haastert, E. S., Bö, L., van der Valk, P., Barkhof, F., & de Vries, H. E. (2005) · Neurobiology of Disease

Multiple Sclerosis Research StudiesBarrier Structure and Function Studies

Cited by 188

The blood-brain barrier in cortical multiple sclerosis lesions

van Horssen, J., Brink, B. P., de Vries, H. E., van der Valk, P., & Bø, L. (2007) · Journal of Neuropathology & Experimental Neurology

Multiple Sclerosis Research StudiesBarrier Structure and Function Studies

Cited by 187

MicroRNAs Regulate Human Brain Endothelial Cell-Barrier Function in Inflammation: Implications for Multiple Sclerosis

Reijerkerk, A., Lopez-Ramirez, M. A., van het Hof, B., Drexhage, J. A. R., Kamphuis, W. W., Kooij, G., Vos, J. B., van der Pouw Kraan, T. C. T. M., van Zonneveld, A. J., Horrevoets, A. J., et al. (2013) · The Journal of Neuroscience

Barrier Structure and Function StudiesMicroRNA in disease regulation

Cited by 138

The blood brain barrier in Alzheimer’s disease

Chakraborty, A., de Wit, N. M., van der Flier, W. M., & de Vries, H. E. (2017) · Vascular Pharmacology

Barrier Structure and Function StudiesAlzheimer's disease research and treatments

Cited by 118

GM‐CSF promotes migration of human monocytes across the blood brain barrier

Vogel, D. Y. S., Kooij, G., Heijnen, P. D. A. M., Breur, M., Peferoen, L. A. N., van der Valk, P., de Vries, H. E., Amor, S., & Dijkstra, C. D. (2015) · European Journal of Immunology

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 94

Meningeal inflammation in multiple sclerosis induces phenotypic changes in cortical microglia that differentially associate with neurodegeneration

van Olst, L., Rodriguez-Mogeda, C., Picon, C., Kiljan, S., James, R. E., Kamermans, A., van der Pol, S. M. A., Knoop, L., Michailidou, I., Drost, E., et al. (2021) · Acta Neuropathologica

Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research Studies

Cited by 87

Characteristics of Dyshoric Capillary Cerebral Amyloid Angiopathy

Richard, E., Carrano, A., Hoozemans, J. J., van Horssen, J., van Haastert, E. S., Eurelings, L. S., de Vries, H. E., Thal, D. R., Eikelenboom, P., van Gool, W. A., et al. (2010) · Journal of Neuropathology & Experimental Neurology

Intracerebral and Subarachnoid Hemorrhage ResearchAlzheimer's disease research and treatments

Cited by 71

Leukemia inhibitory factor modulates production of inflammatory mediators and myelin phagocytosis by macrophages

Hendriks, J. J. A., Slaets, H., Carmans, S., de Vries, H. E., Dijkstra, C. D., Stinissen, P., & Hellings, N. (2008) · Journal of Neuroimmunology

Cytokine Signaling Pathways and InteractionsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 60

ATP-binding cassette transporters P-glycoprotein and breast cancer related protein are reduced in capillary cerebral amyloid angiopathy

Carrano, A., Snkhchyan, H., Kooij, G., van der Pol, S., van Horssen, J., Veerhuis, R., Hoozemans, J., Rozemuller, A., & de Vries, H. E. (2014) · Neurobiology of Aging

Alzheimer's disease research and treatmentsDrug Transport and Resistance Mechanisms

Cited by 51

Arachidonic acid-derived lipid mediators in multiple sclerosis pathogenesis: fueling or dampening disease progression?

Broos, J. Y., van der Burgt, R. T. M., Konings, J., Rijnsburger, M., Werz, O., de Vries, H. E., Giera, M., & Kooij, G. (2024) · Journal of Neuroinflammation

Multiple Sclerosis Research StudiesFatty Acid Research and Health

Cited by 41

Spatially resolved gene signatures of white matter lesion progression in multiple sclerosis

Alsema, A. M., Wijering, M. H. C., Miedema, A., Kotah, J. M., Koster, M., Rijnsburger, M., van Weering, H. R. J., de Vries, H. E., Baron, W., Kooistra, S. M., et al. (2024) · Nature Neuroscience

Multiple Sclerosis Research StudiesSingle-cell and spatial transcriptomics

Cited by 38

Association of Arachidonic Acid–Derived Lipid Mediators With Disease Severity in Patients With Relapsing and Progressive Multiple Sclerosis

Broos, J. Y., Loonstra, F. C., de Ruiter, L. R. J., Gouda, M., Fung, W. H., Schoonheim, M. M., Heijink, M., Strijbis, E. M. M., Teunissen, C., Killestein, J., et al. (2023) · Neurology

Multiple Sclerosis Research StudiesFatty Acid Research and Health

Cited by 29

Endothelial-Ercc1 DNA repair deficiency provokes blood-brain barrier dysfunction

Hansen, C. E., Vacondio, D., van der Molen, L., Jüttner, A. A., Fung, W. K., Karsten, M., van het Hof, B., Fontijn, R. D., Kooij, G., Witte, M. E., et al. (2025) · Cell Death & Disease

Barrier Structure and Function StudiesCerebrovascular and genetic disorders

Cited by 27

Reduced Angiopoietin-Like 4 Expression in Multiple Sclerosis Lesions Facilitates Lipid Uptake by Phagocytes via Modulation of Lipoprotein-Lipase Activity

Kamermans, A., Rijnsburger, M., Chakraborty, A., van der Pol, S., de Vries, H. E., & van Horssen, J. (2019) · Frontiers in Immunology

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 25