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The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Selective Upregulation of Scavenger Receptors in and Around Demyelinating Areas in Multiple Sclerosis

Hendrickx, Debbie A.E., Koning, Nathalie, Schuurman, Karianne G., Strien, Miriam E. van, Eden, Corbert G. van, Hamann, Jörg, Huitinga, Inge·2013·Journal of Neuropathology & Experimental Neurology
DOI 10.1097/nen.0b013e31827fd9e8
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Abstract

Autoantibodies and complement opsonization have been implicated in the process of demyelination in the major human CNS demyelinating disease multiple sclerosis (MS), but scavenger receptors (SRs) may also play pathogenetic roles. We characterized SR mRNA and protein expression in postmortem brain tissue from 13 MS patients in relation to active demyelination. CD68, chemokine (C-X-C motif) ligand 16 (CXCL16), class A macrophage SR (SR-AI/II), LOX-1 (lectin-like oxidized low-density lipoprotein receptor 1), FcγRIII, and LRP-1 (low-density lipoprotein receptor-related protein 1) mRNA were upregulated in the rims of chronic active MS lesions. CD68 and CXCL16 mRNA were also upregulated around chronic active MS lesions. By immunohistochemistry, CD68, CXCL16, and SR-AI/II were expressed by foamy macrophages in the rim and by ramified microglia around chronic active MS lesions. CXCL16 and SR-AI/II were also expressed by astrocytes in MS lesions and by primary human microglia and astrocytes in vitro. These data suggest that SRs are involved in myelin uptake in MS, and that upregulation of CD68, CXCL16, and SR-AI/II is one of the initial events in microglia as they initiate myelin phagocytosis. As demyelination continues, additional upregulation of LOX-1, FcγRIII, and LRP-1 may facilitate this process.

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Crossref · 10.1097/nen.0b013e31827fd9e8

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Research works printed but not linked: 49

  1. 10.1007/BF02527713 · DOI
  2. 10.1002/glia.22298 · DOI
  3. 10.1007/BF02331413 · DOI
  4. Huitinga, 1995, Macrophages in T cell line-mediated, demyelinating, and chronic relapsing experimental autoimmune encephalomyelitis in Lewis rats, Clin Exp Immunol, 100, 344, 10.1111/j.1365-2249.1995.tb03675.x · DOI
  5. 10.1084/jem.172.4.1025 · DOI · Paper page
  6. 10.1016/S0165-5728(99)00133-2 · DOI
  7. 10.1016/S0165-5728(96)00110-5 · DOI
  8. 10.1002/glia.10148 · DOI
  9. 10.1016/j.ymeth.2007.06.004 · DOI
  10. 10.1073/pnas.96.11.6353 · DOI
  11. 10.1172/JCI4533 · DOI
  12. 10.1093/brain/awr128 · DOI
  13. 10.1002/eji.200636912 · DOI
  14. 10.1111/j.1460-9568.1997.tb01694.x · DOI
  15. 10.1016/S0969-9961(02)00008-6 · DOI
  16. 10.1186/1742-2094-9-120 · DOI
  17. 10.4049/jimmunol.173.3.1620 · DOI
  18. 10.1242/jcs.040717 · DOI · Paper page
  19. 10.1093/brain/aws105 · DOI
  20. 10.1111/j.1529-8027.2008.00183.x · DOI
  21. 10.1182/blood-2002-12-3651 · DOI
  22. 10.1084/jem.20060370 · DOI · Paper page
  23. 10.1002/glia.20144 · DOI
  24. Kurushima, 2000, Surface expression and rapid internalization of macrosialin (mouse CD68) on elicited mouse peritoneal macrophages, J Leukoc Biol, 67, 104, 10.1002/jlb.67.1.104 · DOI
  25. 10.1073/pnas.95.16.9535 · DOI
  26. 10.1073/pnas.93.25.14833 · DOI
  27. 10.1006/nbdi.2001.0383 · DOI
  28. 10.4049/jimmunol.0801320 · DOI
  29. Smith, 1987, Differential expression of murine macrophage surface glycoprotein antigens in intracellular membranes, J Cell Sci, 87, 113, 10.1242/jcs.87.1.113 · DOI
  30. 10.1111/j.1745-7254.2008.00823.x · DOI
  31. 10.1002/ana.20016 · DOI
  32. 10.1002/ana.21220 · DOI
  33. 10.1002/1531-8249(200006)47:6<707::AID-ANA3>3.0.CO;2-Q · DOI
  34. 10.1046/j.1365-2990.2000.00217.x · DOI
  35. 10.1006/meth.2001.1262 · DOI · Paper page
  36. 10.1002/glia.22370 · DOI · Paper page
  37. Parwaresch, 1986, Monocyte/macrophage-reactive monoclonal antibody Ki-M6 recognizes an intracytoplasmic antigen, Am J Pathol, 125, 141
  38. 10.1002/ana.1255 · DOI
  39. 10.1002/ana.21311 · DOI
  40. 10.1074/jbc.C000761200 · DOI
  41. 10.1038/79738 · DOI
  42. 10.1016/j.neulet.2005.12.029 · DOI
  43. 10.1161/hq1001.096652 · DOI
  44. 10.1042/bj3340009 · DOI
  45. 10.1016/j.jneuroim.2012.06.004 · DOI
  46. 10.1111/j.1471-4159.2005.03123.x · DOI
  47. 10.1371/journal.pone.0033090 · DOI
  48. 10.1007/s13238-010-0020-3 · DOI
  49. 10.1073/pnas.1111924109 · DOI

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Metadata

Authors
Hendrickx, D. A. E., Koning, N., Schuurman, K. G., Strien, M. E. V., Eden, C. G. V., Hamann, J., & Huitinga, I.
Venue
Journal of Neuropathology & Experimental Neurology
Publisher
Oxford University Press (OUP)
Published
2013-02
Volume
72
Issue
2
Pages
106-118
ISSN
  • 0022-3069
  • 1554-6578
DOI
10.1097/nen.0b013e31827fd9e8
Cited by
72
References
2
Language
en

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