MerTK Is a Functional Regulator of Myelin Phagocytosis by Human Myeloid Cells

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IFN-γ Producing Th1 Cells Induce Different Transcriptional Profiles in Microglia and Astrocytes

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TAM receptors in phagocytosis: Beyond the mere internalization of particles

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Developmental differences in microglia morphology and gene expression during normal brain development and in response to hypoxia-ischemia

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RNA-Seq transcriptomic profiling of primary murine microglia treated with LPS or LPS + IFNγ

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Consequences and mechanisms of myelin debris uptake and processing by cells in the central nervous system

Hammel, G., Zivkovic, S., Ayazi, M., & Ren, Y. (2022) · Cellular Immunology · doi:10.1016/j.cellimm.2022.104591 · Cited by 53 · see citing works

Polarization of microglia and its role in bacterial sepsis

Michels, M., Sonai, B., & Dal‐Pizzol, F. (2017) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2016.12.015 · Cited by 51 · see citing works

Glial Cells as Regulators of Neuroimmune Interactions in the Central Nervous System

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Microglial Turnover in Ageing-Related Neurodegeneration: Therapeutic Avenue to Intervene in Disease Progression

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Role of Transforming Growth Factor Beta in Peripheral Nerve Regeneration: Cellular and Molecular Mechanisms

Ye, Z., Wei, J., Zhan, C., & Hou, J. L. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.917587 · Cited by 42 · see citing works

Myeloid cell‐specific topoisomerase 1 inhibition using DNA origami mitigates neuroinflammation

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Chronic oligodendrocyte injury in central nervous system pathologies

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MerTK is a mediator of alpha-synuclein fibril uptake by human microglia

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The Role of MicroRNAs in Repair Processes in Multiple Sclerosis

Duffy, C. P., & McCoy, C. E. (2020) · Cells · doi:10.3390/cells9071711 · Cited by 42 · see citing works

Microglial Phagocytosis—Rational but Challenging Therapeutic Target in Multiple Sclerosis

Pinto, M. V., & Fernandes, A. M. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21175960 · Cited by 41 · see citing works

Analysis of the microglia transcriptome across the human lifespan using single cell RNA sequencing

Yaqubi, M., Groh, A. M. R., Dorion, M., Afanasiev, E., Luo, J. X. X., Hashemi, H., Sinha, S., Kieran, N. W., Blain, M., Cui, Q., et al. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02809-7 · Cited by 41 · see citing works

Gas6 Inhibits Toll-Like Receptor-Mediated Inflammatory Pathways in Mouse Microglia via Axl and Mer

Gilchrist, S. E., Goudarzi, S., & Hafizi, S. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.576650 · Cited by 44 · see citing works

Phagocytosis by Peripheral Glia: Importance for Nervous System Functions and Implications in Injury and Disease

Nazareth, L., John, J. A. S., Murtaza, M., & Ekberg, J. A. K. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.660259 · Cited by 39 · see citing works

Synapses, Microglia, and Lipids in Alzheimer’s Disease

Paasila, P. J., Aramideh, J. A., Sutherland, G. T., & Graeber, M. B. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.778822 · Cited by 38 · see citing works

Immune Regulatory Functions of Macrophages and Microglia in Central Nervous System Diseases

Poppell, M., Hammel, G., & Ren, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065925 · Cited by 38 · see citing works

Role of peripheral immune cells in spinal cord injury

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Tyro3, Axl, Mertk receptor-mediated efferocytosis and immune regulation in the tumor environment

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Antibody Cross-Linking of CD14 Activates MerTK and Promotes Human Macrophage Clearance of Apoptotic Neutrophils: the Dual Role of CD14 at the Crossroads Between M1 and M2c Polarization

Zizzo, G., & Cohen, P. L. (2018) · Inflammation · doi:10.1007/s10753-018-0864-x · Cited by 35 · see citing works

Microglia in the context of multiple sclerosis

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Sulforaphane rescues amyloid-β peptide-mediated decrease in MerTK expression through its anti-inflammatory effect in human THP-1 macrophages

Jhang, K. A., Park, J., Kim, H.-S., & Chong, Y. H. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1112-x · Cited by 33 · see citing works

Defining Microglial States and Nomenclature: A Roadmap to 2030Preprint

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Role of Apoptotic Cell Clearance in Pneumonia and Inflammatory Lung Disease

Zheng, D. J., Taka, M. A., & Heit, B. (2021) · Pathogens · doi:10.3390/pathogens10020134 · Cited by 32 · see citing works

Identifying disease-critical cell types and cellular processes across the human body by integration of single-cell profiles and human geneticsPreprint

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MFG-E8 Alleviates Cognitive Impairments Induced by Chronic Cerebral Hypoperfusion by Phagocytosing Myelin Debris and Promoting Remyelination

Dong, X., Zhang, Z., Shu, X., Zhuang, Z., Liu, P., Liu, R., Xia, S., Bao, X., Xu, Y., & Chen, Y. (2023) · Neuroscience Bulletin · doi:10.1007/s12264-023-01147-1 · Cited by 30 · see citing works

Myelin debris phagocytosis in demyelinating disease

Gao, R., Song, S., Tian, M., Wang, L., Zhang, Y., & Li, X. (2024) · Glia · doi:10.1002/glia.24602 · Cited by 30 · see citing works

TAM Signaling in the Nervous System

Burstyn-Cohen, T., & Hochberg, A. (2021) · Brain Plasticity · doi:10.3233/bpl-210125 · Cited by 29 · see citing works

Regional and age‐related diversity of human mature oligodendrocytes

Yaqubi, M., Luo, J. X. X., Baig, S., Cui, Q., Petrecca, K., Desu, H. L., Larochelle, C., Afanasiev, E., Hall, J. A., Dudley, R., et al. (2022) · Glia · doi:10.1002/glia.24230 · Cited by 27 · see citing works

Assaying Microglia Functions In Vitro

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Having an Old Friend for Dinner: The Interplay between Apoptotic Cells and Efferocytes

Lam, A. L., & Heit, B. (2021) · Cells · doi:10.3390/cells10051265 · Cited by 22 · see citing works

The glial perspective of autism spectrum disorder convergent evidence from postmortem brain and PET studies

Liao, X., Chen, M., & Li, Y. (2023) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2023.101064 · Cited by 25 · see citing works

Microglial phagocytosis of single dying oligodendrocytes is mediated by CX3CR1 but not MERTK

Olveda, G. E., Barasa, M. N., & Hill, R. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114385 · Cited by 23 · see citing works

The role of microglia heterogeneity in synaptic plasticity and brain disorders: Will sequencing shed light on the discovery of new therapeutic targets?

You, Y., Chen, Z., & Hu, W. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108606 · Cited by 22 · see citing works

Protein S and Gas6 induce efferocytosis of HIV-1-infected cells

Chua, B. A., Ngo, J. A., Situ, K., Ramirez, C. M., Nakano, H., & Morizono, K. (2018) · Virology · doi:10.1016/j.virol.2017.12.025 · Cited by 22 · see citing works

Mertk-expressing microglia influence oligodendrogenesis and myelin modelling in the CNS

Nguyen, L. T., Aprico, A., Nwoke, E. C., Walsh, A. D., Blades, F., Avneri, R., Martin, E., Zalc, B., Kilpatrick, T. J., & Binder, M. D. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02921-8 · Cited by 24 · see citing works

Gene expression profiles of M1 and M2 microglia characterized by comparative analysis of public datasets

Satoh, J. (2017) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.12426 · Cited by 22 · see citing works

Immunology of oligodendrocyte precursor cells in vivo and in vitro

Antel, J. P., Lin, Y. H., Cui, Q., Pernin, F., Kennedy, T. E., Ludwin, S. K., & Healy, L. M. (2018) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2018.03.006 · Cited by 22 · see citing works

Potential Immunotherapeutic Targets on Myeloid Cells for Neurovascular Repair After Ischemic Stroke

Zhu, Z., Li, Z., Li, Y., Huang, T., Chao, Y.-C., Pan, L., Zhu, H. F., Zhao, Y., Yu, W., & Li, P. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00758 · Cited by 22 · see citing works

Exploring the Pro-Phagocytic and Anti-Inflammatory Functions of PACAP and VIP in Microglia: Implications for Multiple Sclerosis

Jansen, M. I., Broome, S. T., & Castorina, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094788 · Cited by 21 · see citing works

Differential transcriptional response profiles in human myeloid cell populations

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Microglia subtypes show substrate- and time-dependent phagocytosis preferences and phenotype plasticity

Li, S., Wernersbach, I., Harms, G. S., & Schäfer, M. K. E. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.945485 · Cited by 20 · see citing works

An adapted protocol to derive microglia from stem cells and its application in the study of CSF1R-related disorders

Dorion, M., Casas, D., Shlaifer, I., Yaqubi, M., Fleming, P., Karpilovsky, N. C., Chen, C. X. ‐., Nicouleau, M., Piscopo, V. E. C., MacDougall, E. J., et al. (2024) · Molecular Neurodegeneration · doi:10.1186/s13024-024-00723-x · Cited by 20 · see citing works

Mechanisms of metabolic stress induced cell death of human oligodendrocytes: relevance for progressive multiple sclerosis

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Vitamin D Regulates MerTK-Dependent Phagocytosis in Human Myeloid Cells

Clarke, J., Yaqubi, M., Futhey, N. C., Sedaghat, S., Baufeld, C., Blain, M., Baranzini, S. E., Butovsky, O., White, J. H., Antel, J. P., et al. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2000129 · Cited by 18 · see citing works

Antagonistic Coevolution of MER Tyrosine Kinase Expression and Function

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Systematic comparison of culture media uncovers phenotypic shift of primary human microglia defined by reduced reliance to CSF1R signaling

Dorion, M., Yaqubi, M., Murdoch, H. J., Hall, J. A., Dudley, R., Antel, J. P., Durcan, T. M., & Healy, L. M. (2023) · Glia · doi:10.1002/glia.24338 · Cited by 17 · see citing works

β-cell function is regulated by metabolic and epigenetic programming of islet-associated macrophages, involving Axl, Mertk, and TGFβ receptor signaling

Thai, L. M., O’Reilly, L., Reibe, S., Sue, N., Holliday, H., Small, L., Schmitz‐Peiffer, C., Dhenni, R., Tsai, V. W.-W., Norris, N., et al. (2023) · iScience · doi:10.1016/j.isci.2023.106477 · Cited by 16 · see citing works

Single-nucleus transcriptomics reveals a distinct microglial state and increased MSR1-mediated phagocytosis as common features across dementia subtypes

Chia, S.-Y., Li, M., Li, Z., Tu, H., Lee, J. W. L., Qiu, L., Ling, J., Reynolds, R., Albani, S., Tan, E.-K., et al. (2025) · Genome Medicine · doi:10.1186/s13073-025-01519-4 · Cited by 15 · see citing works

The Tolerogenic Influence of Dexamethasone on Dendritic Cells Is Accompanied by the Induction of Efferocytosis, Promoted by MERTK

Li, V., Binder, M. D., & Kilpatrick, T. J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115903 · Cited by 16 · see citing works

Inhibition of ADORA3 promotes microglial phagocytosis and alleviates chronic ischemic white matter injury

Xu, Y., Tang, L., Zhou, C., Sun, L., Hu, Y., Zhang, Z., Xia, S., Bao, X., Yang, H., & Xu, Y. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14742 · Cited by 16 · see citing works

Comparative morphology and phagocytic capacity of primary human adult microglia with time-lapse imaging

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Modulation of the Microglial Nogo-A/NgR Signaling Pathway as a Therapeutic Target for Multiple Sclerosis

Nheu, D., Ellen, O., Ye, S., Ozturk, E., Pagnin, M., Kertadjaja, S., Theotokis, P., Grigoriadis, N., Mclean, C. A., & Petratos, S. (2022) · Cells · doi:10.3390/cells11233768 · Cited by 14 · see citing works

Periventricular Microglia Polarization and Morphological Changes Accompany NLRP3 Inflammasome-Mediated Neuroinflammation after Hypoxic–Ischemic White Matter Damage in Premature Rats

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Basic Science of Neuroinflammation and Involvement of the Inflammatory Response in Disorders of the Nervous System

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ROLE OF MICROGLIA IN SEPSIS-ASSOCIATED ENCEPHALOPATHY PATHOGENESIS: AN UPDATE

Yu, Z., Shi, H., Zhang, J., Ma, C., He, C., Yang, F., & Zhao, L. (2023) · Shock · doi:10.1097/shk.0000000000002296 · Cited by 15 · see citing works

Multiple Sclerosis Patient Macrophages Impaired Metabolism Leads to an Altered Response to Activation Stimuli

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Tyrosine Kinase Receptors Axl and MerTK Mediate the Beneficial Effect of Electroacupuncture in a Cuprizone‐Induced Demyelinating Model

Zou, Z., Sun, J., Zheng, K., Wang, Y., Zhao, H., Zhu, K., & Wang, J. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/3205176 · Cited by 14 · see citing works

Pharmacological Tools to Activate Microglia and their Possible use to Study Neural Network Patho-physiology

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Modulating Microglia/Macrophage Activation by CDNF Promotes Transplantation of Fetal Ventral Mesencephalic Graft Survival and Function in a Hemiparkinsonian Rat Model

Tseng, K.-Y., Wu, J., Chen, Y.-H., Airavaara, M., Cheng, C., & Ma, K. (2022) · Biomedicines · doi:10.3390/biomedicines10061446 · Cited by 13 · see citing works

MerTK as a Functional Regulator of Anti-Inflammatory Myelin Phagocytosis by Human Myeloid Cells (P5.273)

Healy, L. M., Perron, G., Won, S., Moore, C. S., Bar‐Or, A., & Antel, J. P. (2016) · Neurology · doi:10.1212/wnl.86.16_supplement.p5.273

MerTK-mediated regulation of myelin phagocytosis by macrophages generated from patients with MS

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Suppression of Microglial Inflammatory Activity by Myelin Phagocytosis: Role of p47-PHOX-Mediated Generation of Reactive Oxygen Species

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Suppression of microglial inflammatory activity by myelin phagocytosis: role of reactive oxygen species generation via p47-PHOX

Liu, Y. (2006) · Aktuelle Neurologie · doi:10.1055/s-2006-953214

Tissue Transglutaminase contributes to myelin phagocytosis in interleukin-4-treated human monocyte-derived macrophages

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