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Cited by 59Assisted Reproductive Technology and Twin PregnancyReproductive Health and TechnologiesMaternal and Perinatal Health Interventions

Reproductive outcomes after assisted conception

Talaulikar, Vikram Sinai, Arulkumaran, Sabaratnam·2012·Obstetrical & Gynecological Survey
DOI 10.1097/ogx.0b013e31826a5d4a
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Abstract

The last three decades have witnessed a dramatic increase in the use of assisted reproductive technology (ART) so that now, in developed countries, 1.7% to 4.0% of all children are born after ART. Although absolute risks appear small, data from prospective and retrospective studies indicate increased risks of adverse maternal and perinatal outcomes after ART as compared with spontaneous conception. Recent studies suggest that underlying maternal factors and subfertility play an important role in some of these outcomes rather than the ART procedure itself. A significant risk of assisted conception is multiple pregnancies, but even singleton pregnancies achieved by ART are at a higher risk of hypertensive disease, diabetes, prematurity, low birth weight, and perinatal mortality even after adjusting for confounders. Couples undergoing ART procedures should be counseled in advance regarding increased risks of pregnancy complications and higher rates of obstetric interventions. Although conflicting data exist, studies of children born from ART suggest increased rates of congenital malformations, imprinting disorders (Beckwith-Wiedemann syndrome and Angelman syndrome), and marginally increased risk of cancer. However, the current evidence is inadequate, and prospective long-term studies are needed to eliminate the effect of confounders and draw definite conclusions about the long-term outcomes after ART. The absolute risk of imprinting disorders remains small, and routine screening is not recommended at present. The long-term outcomes after ART are difficult to evaluate because of the variability in ART methods and data reporting, and there is a need for standardized methodology for follow-up after ART. Target Audience: Obstetricians and gynecologists, family physicians Learning Objectives: After completing this CME activity, physicians should be better able to critique the existing literature on birth outcomes after assisted conception, evaluate the factors that may be involved in causing an increased risk of adverse maternal and perinatal outcomes after assisted conception, and counsel women about risks of adverse pregnancy and long-term outcomes after assisted conception.

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Crossref · 10.1097/ogx.0b013e31826a5d4a

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142 of 142 references verified0 citation errors · 0 not checkable

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Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Fertility therapy may confer unintended health risks to women.

    “Although fertility therapy represents a safe and feasible option for many couples with infertility, these treatments may confer unintended health risks to women.”

    From Cardiovascular Risk Following Fertility Therapy (2017) · cites this paper as [13]

  • The use of fertility therapies to achieve pregnancy in infertile couples is rising in Western countries.

    “The use of fertility therapies to achieve pregnancy in infertile couples is rising in Western countries (13).”

    From Cardiovascular Risk Following Fertility Therapy (2017) · cites this paper as [13]

  • Recent observational data indicate double the risk of severe maternal morbidity in fertility-treated pregnancy when compared with naturally conceived pregnancy.

    “For example, recent observational data indicate double the risk of severe maternal morbidity (13,18,19) in fertility-treated pregnancy when compared with naturally conceived pregnancy.”

    From Cardiovascular Risk Following Fertility Therapy (2017) · cites this paper as [13]

  • Fertility therapy is widely used to achieve pregnancy among older women.

    “This question is increasingly relevant because fertility therapy is widely used to achieve pregnancy among older women, is associated with short-term maternal complications (13,18,19), and its long-term CV safety is unknown.”

    From Cardiovascular Risk Following Fertility Therapy (2017) · cites this paper as [13]

  • Fertility therapy is associated with short-term maternal complications.

    “This question is increasingly relevant because fertility therapy is widely used to achieve pregnancy among older women, is associated with short-term maternal complications (13,18,19), and its long-term CV safety is unknown.”

    From Cardiovascular Risk Following Fertility Therapy (2017) · cites this paper as [13]

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Authors
Talaulikar, V. S., & Arulkumaran, S.
Affiliations
St George's Hospital (GB)
Corresponding author
Talaulikar, Vikram Sinai
ORCID
Venue
Obstetrical & Gynecological Survey
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2012-09
Volume
67
Issue
9
Pages
566-583
ISSN
0029-7828 (ISSN-L)
DOI
10.1097/ogx.0b013e31826a5d4a
OpenAlex
W2076227836
Cited by
59
References
143
Citations by year
2025: 3 · 2024: 1 · 2023: 3 · 2022: 6 · 2021: 5 · 2020: 4 · 2019: 5 · 2018: 5 · 2017: 5 · 2016: 5 · 2015: 8 · 2014: 1 · 2013: 8
FWCI
0.85
Type
journal article
Language
en
Open access
closed
Locations
  • Obstetrical & Gynecological Survey (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Assisted Reproductive Technology and Twin Pregnancy
  • Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
  • Health Sciences › Medicine › Obstetrics and Gynecology › Maternal and Perinatal Health Interventions
Keywords
assisted reproduction, perinatal outcomes, adverse maternal outcomes, multiple pregnancy, preterm birth, low birth weight, perinatal mortality, congenital malformations, imprinting disorders, Beckwith-Wiedemann syndrome, Angelman syndrome, cancer risk, subfertility, pregnancy counseling, long-term outcomes
MeSH terms
Congenital Abnormalities, Culture Media, Embryo Transfer, Female, Humans, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Pregnancy, Multiple, Reproductive Techniques, Assisted

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