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Endometriosis-associated Skeletal Muscle Regeneration: A Hitherto Undescribed Entity and a Potential Diagnostic Pitfall
Abstract
Skeletal muscle undergoes regeneration generally after an injury and in some cases it may mimic a malignant process. We observed these aspects in association with abdominal wall endometriosis and as no similar conditions were found in the literature this prompted us to study the main clinicopathologic and immunohistochemical profile of this phenomenon. Thirteen cases of abdominal wall endometriosis were retrieved from the files of our Institute. All original slides were reviewed to reveal the presence of skeletal muscle and 8 cases were enrolled for morphologic and immunohistochemical studies as follows: vimentin, desmin, myoglobin, myogenin, myoD1, CD56, S100, and p21. Histologically, in 4 of the 8 cases in the skeletal muscle adjacent to the endometriotic foci there was a proliferation of round cells with the typical appearance of maturing myoblasts. More peripherally, myotubes and early myocytes were present. This proliferation was florid in 1 case and focal in 3 cases. At immunohistochemical investigation, the less differentiated cells reacted with vimentin, desmin, S100, CD56, myoD1, and myogenin but not with myoglobin or p21. On the contrary, intermediately differentiated cells showed a progressive loss of vimentin, CD56, and myoD1 whereas they were positive for desmin, S100, myogenin, myoglobin, and p21. Terminally differentiated cells reacted only with desmin and myoglobin. This peculiar immunohistochemical profile was consistent with the immunophenotype of maturing m…
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“The immunohistochemistry staining for CD10 confirmed the endometriotic nature of the stroma [29, 30].”
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References 16 · Cited by 16
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Metadata
- Authors
- Colella, R., Mameli, M. G., Bellezza, G., Sordo, R. D., Cavaliere, A., & Sidoni, A.
- Affiliations
- University of Perugia (IT)
- Corresponding author
- Colella, Renato
- Venue
- American Journal of Surgical Pathology
- Published
- 2010-01
- Volume
- 34
- Issue
- 1
- Pages
- 10-17
- ISSN
- 0147-5185 (ISSN-L)
- OpenAlex
- W2008396995
- Cited by
- 16
- References
- 16
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 1 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 1 · 2014: 1 · 2012: 1
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Surgical Pathology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Oncology › Sarcoma Diagnosis and Treatment
- Keywords
- endometriosis, abdominal wall endometriosis, skeletal muscle regeneration, myoblast proliferation, MyoD, myogenin, desmin, CD56, S-100 protein, myotubes, mimicking malignancy, diagnostic pitfalls, immunohistochemistry, vimentin, myoglobin, p21, frozen section
- MeSH terms
- Adult, Diagnosis, Differential, Endometriosis, Female, Humans, Immunohistochemistry, Middle Aged, Regeneration, Endometrial Neoplasms, Muscle, Skeletal
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- CoChat. (2026). Citation check: Endometriosis-associated Skeletal Muscle Regeneration: A Hitherto Undescribed Entity and a Potential Diagnostic Pitfall. https://app.cochat.ai/papers/10.1097/pas.0b013e3181c12491
- The paper
- Colella, R., Mameli, M. G., Bellezza, G., Sordo, R. D., Cavaliere, A., & Sidoni, A. (2010). Endometriosis-associated Skeletal Muscle Regeneration: A Hitherto Undescribed Entity and a Potential Diagnostic Pitfall. American Journal of Surgical Pathology. https://doi.org/10.1097/pas.0b013e3181c12491
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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